FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3092455145> ?p ?o ?g. }

• W3092455145 endingPage "3227" @default.
• W3092455145 startingPage "3227" @default.
• W3092455145 abstract "Overproduction of reactive oxygen species (ROS) and, as a result, uncontrolled oxidative stress (OS) can play a central role in disorders of fetal hemodynamics and subsequent development of adverse perinatal outcomes in newborns with fetal growth restriction (FGR). Given the epigenetic nature of such disorders, the aim of our study was to evaluate the expression of miRNAs associated with OS and endothelial dysfunction (miR-27a-3p, miR-30b-5p, miR-125b-5p, miR-221-3p, miR-451a and miR-574-3p) in umbilical cord blood using real-time quantitative RT-PCR. ΜiRNA expression was evaluated in patients with FGR delivery before (n = 9 pregnant) and after 34 weeks of gestation (n = 13 pregnant), and the control groups corresponding to the main groups by gestational age (13 pregnant women in each group, respectively). A significant increase in miR-451a expression was detected in late-onset FGR and correlations with fetoplacental and cerebral circulation were established (increase of resistance in the umbilical artery (pulsatility index, PI UA (umbilical artery): r = −0.59, p = 0.001) and a decrease in cerebral blood flow (CPR: r = 0.48, p = 0.009)). The change in miR-125b-5p expression in the placenta is associated with reduced Doppler of cerebral hemodynamics (CPR: r = 0.73, p = 0.003; PI MCA (middle cerebral artery): r = 0.79, p = 0.0007), and newborn weight (r = 0.56, p = 0.04) in early-onset FGR. In addition, significant changes in miR-125b-5p and miR-451a expression in umbilical cord blood plasma were found in newborns with neonatal respiratory distress syndrome (NRDS) (in early-onset FGR) and very low birth weight (VLBW) (in late-onset FGR). A number of key signaling pathways have been identified in which the regulation of the studied miRNAs is involved, including angiogenesis, neurotrophin signaling pathway and oxidative stress response. In general, our study showed that changes of the redox homeostasis in the mother-placenta-fetus system in FGR and subsequent perinatal outcomes may be due to differential expression of oxidative stress-associated miRNAs." @default.
• W3092455145 created "2020-10-15" @default.
• W3092455145 creator A5008418884 @default.
• W3092455145 creator A5010766274 @default.
• W3092455145 creator A5039701466 @default.
• W3092455145 creator A5047915343 @default.
• W3092455145 creator A5086875186 @default.
• W3092455145 date "2020-10-08" @default.
• W3092455145 modified "2023-09-26" @default.
• W3092455145 title "MiRNAs Regulating Oxidative Stress: A Correlation with Doppler Sonography of Uteroplacental Complex and Clinical State Assessments of Newborns in Fetal Growth Restriction" @default.
• W3092455145 cites W1970477227 @default.
• W3092455145 cites W1976985815 @default.
• W3092455145 cites W1980776551 @default.
• W3092455145 cites W1985045118 @default.
• W3092455145 cites W1986188027 @default.
• W3092455145 cites W1989682760 @default.
• W3092455145 cites W1990335913 @default.
• W3092455145 cites W2002505617 @default.
• W3092455145 cites W2019033274 @default.
• W3092455145 cites W2024798078 @default.
• W3092455145 cites W2035136686 @default.
• W3092455145 cites W2044993603 @default.
• W3092455145 cites W2049883415 @default.
• W3092455145 cites W2063771372 @default.
• W3092455145 cites W2107277218 @default.
• W3092455145 cites W2119577460 @default.
• W3092455145 cites W2127214535 @default.
• W3092455145 cites W2127916317 @default.
• W3092455145 cites W2140795583 @default.
• W3092455145 cites W2147470294 @default.
• W3092455145 cites W2150959824 @default.
• W3092455145 cites W2153606612 @default.
• W3092455145 cites W2192080449 @default.
• W3092455145 cites W2224328263 @default.
• W3092455145 cites W2331644446 @default.
• W3092455145 cites W2462695093 @default.
• W3092455145 cites W2515504519 @default.
• W3092455145 cites W2593580368 @default.
• W3092455145 cites W2607108905 @default.
• W3092455145 cites W2611683709 @default.
• W3092455145 cites W2736432480 @default.
• W3092455145 cites W2765807054 @default.
• W3092455145 cites W2798140492 @default.
• W3092455145 cites W2802964336 @default.
• W3092455145 cites W2804692877 @default.
• W3092455145 cites W2887925507 @default.
• W3092455145 cites W2915059917 @default.
• W3092455145 cites W2948430068 @default.
• W3092455145 cites W2949578822 @default.
• W3092455145 cites W2976537701 @default.
• W3092455145 cites W3005173253 @default.
• W3092455145 cites W4211194784 @default.
• W3092455145 doi "https://doi.org/10.3390/jcm9103227" @default.
• W3092455145 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7650709" @default.
• W3092455145 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33050114" @default.
• W3092455145 hasPublicationYear "2020" @default.
• W3092455145 type Work @default.
• W3092455145 sameAs 3092455145 @default.
• W3092455145 citedByCount "7" @default.
• W3092455145 countsByYear W30924551452022 @default.
• W3092455145 crossrefType "journal-article" @default.
• W3092455145 hasAuthorship W3092455145A5008418884 @default.
• W3092455145 hasAuthorship W3092455145A5010766274 @default.
• W3092455145 hasAuthorship W3092455145A5039701466 @default.
• W3092455145 hasAuthorship W3092455145A5047915343 @default.
• W3092455145 hasAuthorship W3092455145A5086875186 @default.
• W3092455145 hasBestOaLocation W30924551451 @default.
• W3092455145 hasConcept C126322002 @default.
• W3092455145 hasConcept C134018914 @default.
• W3092455145 hasConcept C164705383 @default.
• W3092455145 hasConcept C16685009 @default.
• W3092455145 hasConcept C172680121 @default.
• W3092455145 hasConcept C178853913 @default.
• W3092455145 hasConcept C203014093 @default.
• W3092455145 hasConcept C2775841333 @default.
• W3092455145 hasConcept C2776151105 @default.
• W3092455145 hasConcept C2776953305 @default.
• W3092455145 hasConcept C2776955114 @default.
• W3092455145 hasConcept C2778376644 @default.
• W3092455145 hasConcept C2778780700 @default.
• W3092455145 hasConcept C2778964498 @default.
• W3092455145 hasConcept C2779234561 @default.
• W3092455145 hasConcept C541997718 @default.
• W3092455145 hasConcept C54355233 @default.
• W3092455145 hasConcept C71924100 @default.
• W3092455145 hasConcept C86803240 @default.
• W3092455145 hasConceptScore W3092455145C126322002 @default.
• W3092455145 hasConceptScore W3092455145C134018914 @default.
• W3092455145 hasConceptScore W3092455145C164705383 @default.
• W3092455145 hasConceptScore W3092455145C16685009 @default.
• W3092455145 hasConceptScore W3092455145C172680121 @default.
• W3092455145 hasConceptScore W3092455145C178853913 @default.
• W3092455145 hasConceptScore W3092455145C203014093 @default.
• W3092455145 hasConceptScore W3092455145C2775841333 @default.
• W3092455145 hasConceptScore W3092455145C2776151105 @default.
• W3092455145 hasConceptScore W3092455145C2776953305 @default.
• W3092455145 hasConceptScore W3092455145C2776955114 @default.
• W3092455145 hasConceptScore W3092455145C2778376644 @default.

• next