Matches in SemOpenAlex for { <https://semopenalex.org/work/W3092457593> ?p ?o ?g. }
- W3092457593 endingPage "2559" @default.
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- W3092457593 abstract "Following widespread infections of the most recent coronavirus known to infect humans, SARS-CoV-2, attention has turned to potential therapeutic options. With no drug or vaccine yet approved, one focal point of research is to evaluate the potential value of repurposing existing antiviral treatments, with the logical strategy being to identify at least a short-term intervention to prevent within-patient progression, while long-term vaccine strategies unfold. Here, we offer an evolutionary/population-genetic perspective on one approach that may overwhelm the capacity for pathogen defense (i.e., adaptation) - induced mutational meltdown - providing an overview of key concepts, review of previous theoretical and experimental work of relevance, and guidance for future research. Applied with appropriate care, including target specificity, induced mutational meltdown may provide a general, rapidly implemented approach for the within-patient eradication of a wide range of pathogens or other undesirable microorganisms." @default.
- W3092457593 created "2020-10-15" @default.
- W3092457593 creator A5020301143 @default.
- W3092457593 creator A5049146277 @default.
- W3092457593 creator A5053297258 @default.
- W3092457593 creator A5054001603 @default.
- W3092457593 date "2020-10-27" @default.
- W3092457593 modified "2023-10-17" @default.
- W3092457593 title "Imposed mutational meltdown as an antiviral strategy" @default.
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