FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3092469525> ?p ?o ?g. }

• W3092469525 endingPage "24" @default.
• W3092469525 startingPage "24" @default.
• W3092469525 abstract "The potential of a cell to produce all types of differentiated cells in an organism is termed totipotency. Totipotency is an essential property of germ cells, which constitute the germline and pass on the parental genetic material to the progeny. The potential of germ cells to give rise to a whole organism has been the subject of intense research for decades and remains important in order to better understand the molecular mechanisms underlying totipotency. A better understanding of the principles of totipotency in germ cells could also help to generate this potential in somatic cell lineages. Strategies such as transcription factor-mediated reprogramming of differentiated cells to stem cell-like states could benefit from this knowledge. Ensuring pluripotency or even totipotency of reprogrammed stem cells are critical improvements for future regenerative medicine applications. The C. elegans germline provides a unique possibility to study molecular mechanisms that maintain totipotency and the germ cell fate with its unique property of giving rise to meiotic cells Studies that focused on these aspects led to the identification of prominent chromatin-repressing factors such as the C. elegans members of the Polycomb Repressive Complex 2 (PRC2). In this review, we summarize different factors that were recently identified, which use molecular mechanisms such as control of protein translation or chromatin repression to ensure maintenance of totipotency and the germline fate. Additionally, we focus on recently identified factors involved in preventing transcription-factor-mediated conversion of germ cells to somatic lineages. These so-called reprogramming barriers have been shown in some instances to be conserved with regard to their function as a cell fate safeguarding factor in mammals. Overall, continued studies assessing the different aspects of molecular pathways involved in maintaining the germ cell fate in C. elegans may provide more insight into cell fate safeguarding mechanisms also in other species." @default.
• W3092469525 created "2020-10-15" @default.
• W3092469525 creator A5028218202 @default.
• W3092469525 creator A5044791324 @default.
• W3092469525 date "2020-10-07" @default.
• W3092469525 modified "2023-09-23" @default.
• W3092469525 title "Conversion of Germ Cells to Somatic Cell Types in C. elegans" @default.
• W3092469525 cites W1531821806 @default.
• W3092469525 cites W1554851690 @default.
• W3092469525 cites W1845343606 @default.
• W3092469525 cites W1968547041 @default.
• W3092469525 cites W1974508933 @default.
• W3092469525 cites W1982159610 @default.
• W3092469525 cites W1989942781 @default.
• W3092469525 cites W2006995958 @default.
• W3092469525 cites W2018039678 @default.
• W3092469525 cites W2024523631 @default.
• W3092469525 cites W2028684043 @default.
• W3092469525 cites W2029780546 @default.
• W3092469525 cites W2030043909 @default.
• W3092469525 cites W2032640887 @default.
• W3092469525 cites W2033498063 @default.
• W3092469525 cites W2051303735 @default.
• W3092469525 cites W2058051854 @default.
• W3092469525 cites W2074768939 @default.
• W3092469525 cites W2075375055 @default.
• W3092469525 cites W2087345704 @default.
• W3092469525 cites W2091702810 @default.
• W3092469525 cites W2121910267 @default.
• W3092469525 cites W2130659080 @default.
• W3092469525 cites W2135393302 @default.
• W3092469525 cites W2139956822 @default.
• W3092469525 cites W2147858652 @default.
• W3092469525 cites W2149869194 @default.
• W3092469525 cites W2152254997 @default.
• W3092469525 cites W2161131963 @default.
• W3092469525 cites W2166743396 @default.
• W3092469525 cites W2170075528 @default.
• W3092469525 cites W2191924043 @default.
• W3092469525 cites W2512176211 @default.
• W3092469525 cites W2515261543 @default.
• W3092469525 cites W2781838559 @default.
• W3092469525 cites W2887028154 @default.
• W3092469525 cites W2900946000 @default.
• W3092469525 cites W2924256874 @default.
• W3092469525 cites W2979783981 @default.
• W3092469525 cites W3082859234 @default.
• W3092469525 cites W4233675163 @default.
• W3092469525 doi "https://doi.org/10.3390/jdb8040024" @default.
• W3092469525 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7712076" @default.
• W3092469525 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33036439" @default.
• W3092469525 hasPublicationYear "2020" @default.
• W3092469525 type Work @default.
• W3092469525 sameAs 3092469525 @default.
• W3092469525 citedByCount "2" @default.
• W3092469525 countsByYear W30924695252020 @default.
• W3092469525 countsByYear W30924695252021 @default.
• W3092469525 crossrefType "journal-article" @default.
• W3092469525 hasAuthorship W3092469525A5028218202 @default.
• W3092469525 hasAuthorship W3092469525A5044791324 @default.
• W3092469525 hasBestOaLocation W30924695251 @default.
• W3092469525 hasConcept C104317684 @default.
• W3092469525 hasConcept C109825262 @default.
• W3092469525 hasConcept C134305767 @default.
• W3092469525 hasConcept C145103041 @default.
• W3092469525 hasConcept C148738053 @default.
• W3092469525 hasConcept C1491633281 @default.
• W3092469525 hasConcept C163952510 @default.
• W3092469525 hasConcept C2779122487 @default.
• W3092469525 hasConcept C28328180 @default.
• W3092469525 hasConcept C54355233 @default.
• W3092469525 hasConcept C77255625 @default.
• W3092469525 hasConcept C83640560 @default.
• W3092469525 hasConcept C86339819 @default.
• W3092469525 hasConcept C86803240 @default.
• W3092469525 hasConcept C95444343 @default.
• W3092469525 hasConceptScore W3092469525C104317684 @default.
• W3092469525 hasConceptScore W3092469525C109825262 @default.
• W3092469525 hasConceptScore W3092469525C134305767 @default.
• W3092469525 hasConceptScore W3092469525C145103041 @default.
• W3092469525 hasConceptScore W3092469525C148738053 @default.
• W3092469525 hasConceptScore W3092469525C1491633281 @default.
• W3092469525 hasConceptScore W3092469525C163952510 @default.
• W3092469525 hasConceptScore W3092469525C2779122487 @default.
• W3092469525 hasConceptScore W3092469525C28328180 @default.
• W3092469525 hasConceptScore W3092469525C54355233 @default.
• W3092469525 hasConceptScore W3092469525C77255625 @default.
• W3092469525 hasConceptScore W3092469525C83640560 @default.
• W3092469525 hasConceptScore W3092469525C86339819 @default.
• W3092469525 hasConceptScore W3092469525C86803240 @default.
• W3092469525 hasConceptScore W3092469525C95444343 @default.
• W3092469525 hasFunder F4320313707 @default.
• W3092469525 hasIssue "4" @default.
• W3092469525 hasLocation W30924695251 @default.
• W3092469525 hasLocation W30924695252 @default.
• W3092469525 hasLocation W30924695253 @default.
• W3092469525 hasLocation W30924695254 @default.
• W3092469525 hasOpenAccess W3092469525 @default.

• next