FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3092478305> ?p ?o ?g. }

• W3092478305 endingPage "3659" @default.
• W3092478305 startingPage "3646" @default.
• W3092478305 abstract "// Purab Pal 1 , Karen Hales 2 and Dale Buchanan Hales 1 , 2 1 Department of Physiology, Southern Illinois University, Carbondale, IL 62901, USA 2 Department of Obstetrics and Gynecology, Southern Illinois University School of Medicine, Springfield, IL 62702, USA Correspondence to: Dale Buchanan Hales, email: dhales@siumed.edu Keywords: 2-methoxyestradiol; ovarian cancer; protein kinase C&#x03B4;; p38 MAPK; apoptosis Received: July 09, 2020     Accepted: September 10, 2020     Published: October 06, 2020 Copyright: © 2020 Pal et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. ABSTRACT Background: 2-methoxyestradiol (2MeOE 2 ) is a natural metabolite of estradiol, which is generated by the action of CYP1A1 enzyme in the liver. We have previously shown that a flaxseed-supplemented diet decreases both the incidence and severity of ovarian cancer in laying hens, also induces CYP1A1 expression in liver. Recently, we have shown that as a biologically derived active component of flax diet, 2MeOE 2 induces apoptosis in ovarian cancer cells which is partially dependent on p38 MAPK. The objective of this study was to elucidate the molecular mechanism of actions of 2MeOE 2 , a known microtubule disrupting agent, in inducing apoptosis in ovarian tumors. Results: 2MeOE 2 induces &#x03B3;H2Ax expression and apoptotic histone modifications in ovarian cancer cells, which are predicted downstream targets of protein kinase C&#x03B4; (PKC&#x03B4;) during apoptosis. Overexpressing full length PKC&#x03B4; alone does not induce apoptosis but potentiates 2MeOE 2 -mediated apoptosis. C3-domain mutated dominant-negative PKC&#x03B4; (PKC&#x03B4; DN ) significantly reduces 2MeOE 2 -induced caspase-3 cleavage and apoptotic histone modification. Silencing PKC&#x03B4; diminishes 2MeOE 2 -mediated apoptosis. The catalytic fragment of PKC&#x03B4; (PKC&#x03B4; CAT ) evokes pro-apoptotic effects which are principally dependent on p38 MAPK phosphorylation. Conclusions: The pro-apoptotic actions of 2MeOE 2 are in part dependent on catalytic activation of PKC&#x03B4;. Catalytic activation of PKC&#x03B4; accelerates the 2MeOE 2 -induced apoptotic cascade. This study describes a novel molecular action of flaxseed diet in ovarian cancer." @default.
• W3092478305 created "2020-10-15" @default.
• W3092478305 creator A5016793878 @default.
• W3092478305 creator A5019864786 @default.
• W3092478305 creator A5066607429 @default.
• W3092478305 date "2020-10-06" @default.
• W3092478305 modified "2023-10-01" @default.
• W3092478305 title "The pro-apoptotic actions of 2-methoxyestradiol against ovarian cancer involve catalytic activation of PKCδ signaling" @default.
• W3092478305 cites W1499019277 @default.
• W3092478305 cites W1557630738 @default.
• W3092478305 cites W1559321175 @default.
• W3092478305 cites W1758017998 @default.
• W3092478305 cites W1842412546 @default.
• W3092478305 cites W1967246494 @default.
• W3092478305 cites W1968835387 @default.
• W3092478305 cites W1969588285 @default.
• W3092478305 cites W1970203467 @default.
• W3092478305 cites W1970708444 @default.
• W3092478305 cites W1976769209 @default.
• W3092478305 cites W1978127390 @default.
• W3092478305 cites W1978661875 @default.
• W3092478305 cites W1980291812 @default.
• W3092478305 cites W1982469575 @default.
• W3092478305 cites W1983964043 @default.
• W3092478305 cites W1984367801 @default.
• W3092478305 cites W1986222895 @default.
• W3092478305 cites W1989039704 @default.
• W3092478305 cites W1992213480 @default.
• W3092478305 cites W2001399809 @default.
• W3092478305 cites W2001447034 @default.
• W3092478305 cites W2002698073 @default.
• W3092478305 cites W2006668556 @default.
• W3092478305 cites W2007896773 @default.
• W3092478305 cites W2012921202 @default.
• W3092478305 cites W2015655901 @default.
• W3092478305 cites W2015662278 @default.
• W3092478305 cites W2032888205 @default.
• W3092478305 cites W2035915355 @default.
• W3092478305 cites W2036187132 @default.
• W3092478305 cites W2045938138 @default.
• W3092478305 cites W2047579697 @default.
• W3092478305 cites W2047817078 @default.
• W3092478305 cites W2051948533 @default.
• W3092478305 cites W2055660210 @default.
• W3092478305 cites W2059627263 @default.
• W3092478305 cites W2060421587 @default.
• W3092478305 cites W2060666628 @default.
• W3092478305 cites W2070264733 @default.
• W3092478305 cites W2071999898 @default.
• W3092478305 cites W2072862422 @default.
• W3092478305 cites W2078853699 @default.
• W3092478305 cites W2081217031 @default.
• W3092478305 cites W2083107204 @default.
• W3092478305 cites W2089025179 @default.
• W3092478305 cites W2098851635 @default.
• W3092478305 cites W2101117526 @default.
• W3092478305 cites W2105421288 @default.
• W3092478305 cites W2106065518 @default.
• W3092478305 cites W2108408221 @default.
• W3092478305 cites W2117139617 @default.
• W3092478305 cites W2120646148 @default.
• W3092478305 cites W2126681184 @default.
• W3092478305 cites W2127646052 @default.
• W3092478305 cites W2129900873 @default.
• W3092478305 cites W2133037422 @default.
• W3092478305 cites W2143658931 @default.
• W3092478305 cites W2147096476 @default.
• W3092478305 cites W2161322323 @default.
• W3092478305 cites W2163368660 @default.
• W3092478305 cites W2166435019 @default.
• W3092478305 cites W2176050029 @default.
• W3092478305 cites W2315835538 @default.
• W3092478305 cites W2316804842 @default.
• W3092478305 cites W2330248224 @default.
• W3092478305 cites W2332678957 @default.
• W3092478305 cites W2333004056 @default.
• W3092478305 cites W2345983606 @default.
• W3092478305 cites W2580762211 @default.
• W3092478305 cites W2588719249 @default.
• W3092478305 cites W2594207852 @default.
• W3092478305 cites W2739174192 @default.
• W3092478305 cites W2767867950 @default.
• W3092478305 cites W2801256833 @default.
• W3092478305 cites W2946993743 @default.
• W3092478305 cites W3186551549 @default.
• W3092478305 doi "https://doi.org/10.18632/oncotarget.27760" @default.
• W3092478305 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7546757" @default.
• W3092478305 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33088425" @default.
• W3092478305 hasPublicationYear "2020" @default.
• W3092478305 type Work @default.
• W3092478305 sameAs 3092478305 @default.
• W3092478305 citedByCount "5" @default.
• W3092478305 countsByYear W30924783052021 @default.
• W3092478305 countsByYear W30924783052022 @default.
• W3092478305 countsByYear W30924783052023 @default.
• W3092478305 crossrefType "journal-article" @default.
• W3092478305 hasAuthorship W3092478305A5016793878 @default.
• W3092478305 hasAuthorship W3092478305A5019864786 @default.

• next