Matches in SemOpenAlex for { <https://semopenalex.org/work/W3092488134> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W3092488134 endingPage "S344" @default.
- W3092488134 startingPage "S343" @default.
- W3092488134 abstract "Background and Aims: Colorectal liver metastases (CRLM) develop in 60% of patients diagnosed with colorectal cancer. Surgical resection for CRLM might involve anatomical (AH) or parenchymal-sparing hepatectomies (PSH). Short-term and oncological outcomes of AH and PSH for CRLM patients with multifocal (=4 tumors) disease have not been completely understood. Material & Methods: In this retrospective international multi-institutional study, we sought to investigate the short and long-term outcomes of patients who underwent PSH versus AH for multifocal CRLM at six tertiary referrals centers. Results: Among 1,841 patients who underwent surgery for CRLM, 299 (16%) patients had =4 metastasis and were included in the study. While 177 (59%) patients underwent AH, 122 (41%) patients underwent PSH with a mean of 5.2 liver resections. Patients undergoing AH had a mean tumor burden score (TBS) of 8.9 compared with 7.2 for patients in the PSH group (p<0.01). Even though the incidence of overall complications and bile leak was similar between the two groups (both p-values >0.20), patients in the PSH had a lower incidence of post-hepatectomy liver failure (PHLF) compared with AH patients (AH, n=10, 6% vs. PSH, n=1, 1%; p=0.03). The incidence of 90-day mortality was 6% (n=10) among AH patients compared with 1% (n=1) for PSH patients (p=0.03). In the multivariable survival model adjusted for TBS (HR=1.01), and genetic status (reference KRAS/NRAS/BRAF wild-type: KRAS/NRAS mutated, HR=1.5, BRAF mutated, HR=4.1), patients in the AH group had a 1.9-fold higher risk of death compared with PSH patients (reference PSH: AH patients, HR=1.9, p=0.015). Conclusion: While patients undergoing PSH for multifocal (=4 tumors) CRLM had a lower TBS than AH, PSH patients had a lower incidence of PHLF and 90-day mortality than AH patients. In the multivariable survival model adjusted for TBS and tumors' genetic status, AH patients had a higher risk of death compared with PSH patients." @default.
- W3092488134 created "2020-10-15" @default.
- W3092488134 creator A5004589339 @default.
- W3092488134 creator A5007268728 @default.
- W3092488134 creator A5014748431 @default.
- W3092488134 creator A5016519845 @default.
- W3092488134 creator A5023140410 @default.
- W3092488134 creator A5023690844 @default.
- W3092488134 creator A5034483296 @default.
- W3092488134 creator A5035435527 @default.
- W3092488134 creator A5041752841 @default.
- W3092488134 creator A5065551581 @default.
- W3092488134 creator A5067279221 @default.
- W3092488134 creator A5067905052 @default.
- W3092488134 creator A5074822109 @default.
- W3092488134 creator A5079913663 @default.
- W3092488134 date "2020-01-01" @default.
- W3092488134 modified "2023-09-28" @default.
- W3092488134 title "Parenchymal sparing versus anatomical hepatectomies in patients with multifocal (=4 tumors) colorectal liver metastasis: Results of an international multi-institutional analysis" @default.
- W3092488134 doi "https://doi.org/10.1016/j.hpb.2020.04.347" @default.
- W3092488134 hasPublicationYear "2020" @default.
- W3092488134 type Work @default.
- W3092488134 sameAs 3092488134 @default.
- W3092488134 citedByCount "0" @default.
- W3092488134 crossrefType "journal-article" @default.
- W3092488134 hasAuthorship W3092488134A5004589339 @default.
- W3092488134 hasAuthorship W3092488134A5007268728 @default.
- W3092488134 hasAuthorship W3092488134A5014748431 @default.
- W3092488134 hasAuthorship W3092488134A5016519845 @default.
- W3092488134 hasAuthorship W3092488134A5023140410 @default.
- W3092488134 hasAuthorship W3092488134A5023690844 @default.
- W3092488134 hasAuthorship W3092488134A5034483296 @default.
- W3092488134 hasAuthorship W3092488134A5035435527 @default.
- W3092488134 hasAuthorship W3092488134A5041752841 @default.
- W3092488134 hasAuthorship W3092488134A5065551581 @default.
- W3092488134 hasAuthorship W3092488134A5067279221 @default.
- W3092488134 hasAuthorship W3092488134A5067905052 @default.
- W3092488134 hasAuthorship W3092488134A5074822109 @default.
- W3092488134 hasAuthorship W3092488134A5079913663 @default.
- W3092488134 hasBestOaLocation W30924881341 @default.
- W3092488134 hasConcept C120665830 @default.
- W3092488134 hasConcept C121332964 @default.
- W3092488134 hasConcept C121608353 @default.
- W3092488134 hasConcept C126322002 @default.
- W3092488134 hasConcept C141071460 @default.
- W3092488134 hasConcept C159110652 @default.
- W3092488134 hasConcept C167135981 @default.
- W3092488134 hasConcept C21790070 @default.
- W3092488134 hasConcept C2776909242 @default.
- W3092488134 hasConcept C2779013556 @default.
- W3092488134 hasConcept C2781187634 @default.
- W3092488134 hasConcept C526805850 @default.
- W3092488134 hasConcept C61511704 @default.
- W3092488134 hasConcept C71924100 @default.
- W3092488134 hasConcept C90924648 @default.
- W3092488134 hasConceptScore W3092488134C120665830 @default.
- W3092488134 hasConceptScore W3092488134C121332964 @default.
- W3092488134 hasConceptScore W3092488134C121608353 @default.
- W3092488134 hasConceptScore W3092488134C126322002 @default.
- W3092488134 hasConceptScore W3092488134C141071460 @default.
- W3092488134 hasConceptScore W3092488134C159110652 @default.
- W3092488134 hasConceptScore W3092488134C167135981 @default.
- W3092488134 hasConceptScore W3092488134C21790070 @default.
- W3092488134 hasConceptScore W3092488134C2776909242 @default.
- W3092488134 hasConceptScore W3092488134C2779013556 @default.
- W3092488134 hasConceptScore W3092488134C2781187634 @default.
- W3092488134 hasConceptScore W3092488134C526805850 @default.
- W3092488134 hasConceptScore W3092488134C61511704 @default.
- W3092488134 hasConceptScore W3092488134C71924100 @default.
- W3092488134 hasConceptScore W3092488134C90924648 @default.
- W3092488134 hasLocation W30924881341 @default.
- W3092488134 hasOpenAccess W3092488134 @default.
- W3092488134 hasPrimaryLocation W30924881341 @default.
- W3092488134 hasRelatedWork W1751390532 @default.
- W3092488134 hasRelatedWork W2113677807 @default.
- W3092488134 hasRelatedWork W2150330922 @default.
- W3092488134 hasRelatedWork W2336951002 @default.
- W3092488134 hasRelatedWork W2469896930 @default.
- W3092488134 hasRelatedWork W2474267498 @default.
- W3092488134 hasRelatedWork W2963015396 @default.
- W3092488134 hasRelatedWork W3111923637 @default.
- W3092488134 hasRelatedWork W3159338278 @default.
- W3092488134 hasRelatedWork W4307877771 @default.
- W3092488134 hasVolume "22" @default.
- W3092488134 isParatext "false" @default.
- W3092488134 isRetracted "false" @default.
- W3092488134 magId "3092488134" @default.
- W3092488134 workType "article" @default.