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- W3092505513 abstract "Introduction: With the recent worldwide outbreak of COVID-19, it became clear that certain comorbidities areassociated with an increased risk of complications and death Several publications have reported an increased rateof ICU admission and mortality in cancer patients This has led to guidelines advising more conservativeapproaches to cancer therapy, including chemotherapy In the absence of prospective, disease-specific outcomedata, there is a risk of overestimating the risk of COVID-19 and thus increasing cancer-specific mortality or ofunderestimating MammaPrint has been validated for selecting clinically high-risk breast cancer patients in whomchemotherapy can be avoided safely Methods: We evaluated the current published literature related to the potential risk of breast cancer andchemotherapy in association with COVID-19 We estimated the potential risk of severe events in COVID-19 breastcancer patients receiving adjuvant chemotherapy to assess whether MammaPrint could help us further in makingchemotherapy decisions specific to an infectious epidemic risk Results: The risk of COVID-19 morbidity and mortality in patients receiving chemotherapy could be greater than 1 5to 2 times higher than usual However, other associated conditions frequently found in the breast cancer populationseem to still play a significant role in a worse outcome We found no data to quantify the effect of chemotherapy ordata allowing us to adapt the MammaPrint Score to risk in an infectious epidemic Conclusion: Adjuvant chemotherapy carries a potential risk for morbidity and mortality Data from the currentliterature do not show the magnitude of the added risk for breast cancer patients on adjuvant chemotherapy inassociation with SARS Cov-2 infection By using MammaPrint in hormone receptor-positive patients with up to threenodes in whom chemotherapy is considered, the treatment-related risk can be limited, allowing safe de-escalation oftherapy without increased cancer-specific mortality We plan to pursue the statistical question of how the level of riskat any of the sites on the spectrum relates to distant metastasis-free survival so that mortality risks can be betterestimated during an infection" @default.
- W3092505513 created "2020-10-15" @default.
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- W3092505513 date "2020-01-01" @default.
- W3092505513 modified "2023-09-27" @default.
- W3092505513 title "Using MammaPrint to reduce the needfor chemotherapy in early breast cancer during theCOVID-19 pandemic" @default.
- W3092505513 hasPublicationYear "2020" @default.
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