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• W3092507974 abstract "ABSTRACT Background Previous studies suggest associations between restless leg syndrome (RLS) and atherosclerosis, but these have primarily been based upon subjective atherosclerotic measures. Objective We evaluated associations between RLS and an objective indicator of atherosclerosis, namely carotid intima‐media thickness (cIMT). Methods In this cross‐sectional study among 30,097 Canadian Longitudinal Study on Aging (CLSA) participants, we used a four‐item questionnaire to screen for probable‐RLS. cIMT was measured at the bifurcation of the common carotid artery. Associations were tested with linear regression adjusting for age, sex, ferritin, pulmonary disease, smoking, alcohol, physical activity, anxiety, depression, and other sleep diagnoses. Results Among 26,304 included participants, 2047 (7.8%) had probable‐RLS. Mean cIMT was higher (0.755 ± 0.17 vs 0.736 ± 0.17, P < 0.001) in those with RLS, even after excluding those without prior atherosclerotic diseases (0.740 ± 0.17 vs 0.723 ± 0.16, P = 0.016). Conclusion RLS is associated with objective measures of atherosclerosis. © 2020 International Parkinson and Movement Disorder Society" @default.
• W3092507974 created "2020-10-15" @default.
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• W3092507974 date "2020-10-12" @default.
• W3092507974 modified "2023-09-27" @default.
• W3092507974 title "Restless Leg Syndrome and Objectively‐Measured Atherosclerosis in the Canadian Longitudinal Study on Aging" @default.
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• W3092507974 doi "https://doi.org/10.1002/mds.28326" @default.
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