Matches in SemOpenAlex for { <https://semopenalex.org/work/W3092540597> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W3092540597 endingPage "3244" @default.
- W3092540597 startingPage "3244" @default.
- W3092540597 abstract "A “Practice Pearl” helps an allergist-immunologist practice more safely, effectively, timely, efficiently, equitably, or in a more patient-centered way. This feature is coordinated by Stuart Abramson, MD, Giselle Mosnaim, MD, and Andrew Murphy, MD, from the AAAAI Federation of Regional, State, and Local Allergy, Asthma, and Immunology Societies Assembly and by Editorial Board member Matthew Rank, MD. More information about submitting a “Practice Pearl” can be found on our Web site (jaci-inpractice.org). A “Practice Pearl” helps an allergist-immunologist practice more safely, effectively, timely, efficiently, equitably, or in a more patient-centered way. This feature is coordinated by Stuart Abramson, MD, Giselle Mosnaim, MD, and Andrew Murphy, MD, from the AAAAI Federation of Regional, State, and Local Allergy, Asthma, and Immunology Societies Assembly and by Editorial Board member Matthew Rank, MD. More information about submitting a “Practice Pearl” can be found on our Web site (jaci-inpractice.org). Rapid drug desensitization (RDD) with chemotherapeutics represents an important procedure in treating oncology patients with immediate drug hypersensitivity, protecting them against anaphylaxis and maintaining them on first-line therapy.1Bonamichi-Santos R. Castells M. Diagnoses and management of drug hypersensitivity and anaphylaxis in cancer and chronic inflammatory diseases: reactions to taxanes and monoclonal antibodies.Clin Rev Allergy Immunol. 2018; 54: 375-385Crossref PubMed Scopus (24) Google Scholar RDD is regularly applied in 3-4 solution protocols, whereby continuous infusion of the total dose without any interruption is essential for successful desensitization. Bags with different chemotherapy solutions are prepared by hospital pharmacy following patient and occupational safety standards.2European ParliamentPreventing occupational exposure to cytotoxic and other hazardous drugs: European policy recommendations.https://www.europeanbiosafetynetwork.eu/wp-content/uploads/2016/05/Exposure-to-Cytotoxic-Drugs_Recommendation_DINA4_10-03-16.pdfDate accessed: March 1, 2020Google Scholar Because of safety requirements, that is, closed system drug transfer, bags are delivered with the line filled with a neutral solution, which leads to the challenge that lines need to be flushed with the chemotherapy solution without any risk for the patient during RDD or the health care worker due to accidental chemotherapy exposure. We developed an infusion tree construction that allows flushing the lines with the chemotherapy solutions and subsequently administering RDD treatment without interruption or risk of accidental exposure (see Figure E1 in this article's Online Repository at www.jaci-inpractice.org). Chemotherapy solutions, neutral solutions, and an empty waste bag are connected with lines filled with a neutral solution in a closed system. The lines are then flushed in a specific sequence (see Figures E1 and E2 in this article's Online Repository at www.jaci-inpractice.org) into a waste bag. After flushing the waste line, the waste bag can be disconnected and the prepared closed system is used for RDD, starting with the lowest concentration (solution 1). It is important to accurately measure all line volumes and follow the correct order when flushing the lines to prevent mixing of solutions during flushing the drip chamber and line, due to different osmolarities. The effect of differences in osmolarities is insignificant for most chemotherapy drugs but can be prevented by flushing the lines with a higher volume of the chemotherapy solution. In our clinic, 19 patients have undergone 74 RDD successfully using this technique. Download .ppsx (.14 MB) Help with ppsx files FIGURE E1Procedure of flushing the lines with the chemotherapy solutions. K, 5- to 3-way stopcock (see Figure E2); N, neutral solution; P, patient; W, waste bag; 1, (lowest concentration) cytostatic solution 1; 2, cytostatic solution 2; 3, (highest concentration) cytostatic solution 3. Download .jpg (.24 MB) Help with files Figure E2A 5- to 3-way stopcock is used for building the infusion tree." @default.
- W3092540597 created "2020-10-15" @default.
- W3092540597 creator A5000879687 @default.
- W3092540597 creator A5013908851 @default.
- W3092540597 creator A5021388723 @default.
- W3092540597 creator A5023957995 @default.
- W3092540597 creator A5024948548 @default.
- W3092540597 creator A5035665514 @default.
- W3092540597 creator A5087119348 @default.
- W3092540597 date "2020-10-01" @default.
- W3092540597 modified "2023-09-26" @default.
- W3092540597 title "The Infusion Tree: Safe Administration of Chemotherapeutics during Rapid Drug Desensitization" @default.
- W3092540597 cites W2413885532 @default.
- W3092540597 doi "https://doi.org/10.1016/j.jaip.2020.05.039" @default.
- W3092540597 hasPublicationYear "2020" @default.
- W3092540597 type Work @default.
- W3092540597 sameAs 3092540597 @default.
- W3092540597 citedByCount "0" @default.
- W3092540597 crossrefType "journal-article" @default.
- W3092540597 hasAuthorship W3092540597A5000879687 @default.
- W3092540597 hasAuthorship W3092540597A5013908851 @default.
- W3092540597 hasAuthorship W3092540597A5021388723 @default.
- W3092540597 hasAuthorship W3092540597A5023957995 @default.
- W3092540597 hasAuthorship W3092540597A5024948548 @default.
- W3092540597 hasAuthorship W3092540597A5035665514 @default.
- W3092540597 hasAuthorship W3092540597A5087119348 @default.
- W3092540597 hasBestOaLocation W30925405971 @default.
- W3092540597 hasConcept C104863432 @default.
- W3092540597 hasConcept C126322002 @default.
- W3092540597 hasConcept C170493617 @default.
- W3092540597 hasConcept C203014093 @default.
- W3092540597 hasConcept C207480886 @default.
- W3092540597 hasConcept C2775933838 @default.
- W3092540597 hasConcept C2779060952 @default.
- W3092540597 hasConcept C2779779143 @default.
- W3092540597 hasConcept C3020633164 @default.
- W3092540597 hasConcept C512399662 @default.
- W3092540597 hasConcept C71924100 @default.
- W3092540597 hasConceptScore W3092540597C104863432 @default.
- W3092540597 hasConceptScore W3092540597C126322002 @default.
- W3092540597 hasConceptScore W3092540597C170493617 @default.
- W3092540597 hasConceptScore W3092540597C203014093 @default.
- W3092540597 hasConceptScore W3092540597C207480886 @default.
- W3092540597 hasConceptScore W3092540597C2775933838 @default.
- W3092540597 hasConceptScore W3092540597C2779060952 @default.
- W3092540597 hasConceptScore W3092540597C2779779143 @default.
- W3092540597 hasConceptScore W3092540597C3020633164 @default.
- W3092540597 hasConceptScore W3092540597C512399662 @default.
- W3092540597 hasConceptScore W3092540597C71924100 @default.
- W3092540597 hasIssue "9" @default.
- W3092540597 hasLocation W30925405971 @default.
- W3092540597 hasOpenAccess W3092540597 @default.
- W3092540597 hasPrimaryLocation W30925405971 @default.
- W3092540597 hasRelatedWork W2039668629 @default.
- W3092540597 hasRelatedWork W2282266379 @default.
- W3092540597 hasRelatedWork W2309874743 @default.
- W3092540597 hasRelatedWork W2339380275 @default.
- W3092540597 hasRelatedWork W2769073740 @default.
- W3092540597 hasRelatedWork W2911904393 @default.
- W3092540597 hasRelatedWork W3035291453 @default.
- W3092540597 hasRelatedWork W4235147606 @default.
- W3092540597 hasRelatedWork W4299515071 @default.
- W3092540597 hasRelatedWork W2937552706 @default.
- W3092540597 hasVolume "8" @default.
- W3092540597 isParatext "false" @default.
- W3092540597 isRetracted "false" @default.
- W3092540597 magId "3092540597" @default.
- W3092540597 workType "article" @default.
.%20A%20%E2%80%9CPractice%20Pearl%E2%80%9D%20helps%20an%20allergist-immunologist%20practice%20more%20safely%2C%20effectively%2C%20timely%2C%20efficiently%2C%20equitably%2C%20or%20in%20a%20more%20patient-centered%20way.%20This%20feature%20is%20coordinated%20by%20Stuart%20Abramson%2C%20MD%2C%20Giselle%20Mosnaim%2C%20MD%2C%20and%20Andrew%20Murphy%2C%20MD%2C%20from%20the%20AAAAI%20Federation%20of%20Regional%2C%20State%2C%20and%20Local%20Allergy%2C%20Asthma%2C%20and%20Immunology%20Societies%20Assembly%20and%20by%20Editorial%20Board%20member%20Matthew%20Rank%2C%20MD.%20More%20information%20about%20submitting%20a%20%E2%80%9CPractice%20Pearl%E2%80%9D%20can%20be%20found%20on%20our%20Web%20site%20(jaci-inpractice.org).%20Rapid%20drug%20desensitization%20(RDD)%20with%20chemotherapeutics%20represents%20an%20important%20procedure%20in%20treating%20oncology%20patients%20with%20immediate%20drug%20hypersensitivity%2C%20protecting%20them%20against%20anaphylaxis%20and%20maintaining%20them%20on%20first-line%20therapy.1Bonamichi-Santos%20R.%20Castells%20M.%20Diagnoses%20and%20management%20of%20drug%20hypersensitivity%20and%20anaphylaxis%20in%20cancer%20and%20chronic%20inflammatory%20diseases%3A%20reactions%20to%20taxanes%20and%20monoclonal%20antibodies.Clin%20Rev%20Allergy%20Immunol.%202018%3B%2054%3A%20375-385Crossref%20PubMed%20Scopus%20(24)%20Google%20Scholar%20RDD%20is%20regularly%20applied%20in%203-4%20solution%20protocols%2C%20whereby%20continuous%20infusion%20of%20the%20total%20dose%20without%20any%20interruption%20is%20essential%20for%20successful%20desensitization.%20Bags%20with%20different%20chemotherapy%20solutions%20are%20prepared%20by%20hospital%20pharmacy%20following%20patient%20and%20occupational%20safety%20standards.2European%20ParliamentPreventing%20occupational%20exposure%20to%20cytotoxic%20and%20other%20hazardous%20drugs%3A%20European%20policy%20recommendations.https%3A%2F%2Fwww.europeanbiosafetynetwork.eu%2Fwp-content%2Fuploads%2F2016%2F05%2FExposure-to-Cytotoxic-Drugs_Recommendation_DINA4_10-03-16.pdfDate%20accessed%3A%20March%201%2C%202020Google%20Scholar%20Because%20of%20safety%20requirements%2C%20that%20is%2C%20closed%20system%20drug%20transfer%2C%20bags%20are%20delivered%20with%20the%20line%20filled%20with%20a%20neutral%20solution%2C%20which%20leads%20to%20the%20challenge%20that%20lines%20need%20to%20be%20flushed%20with%20the%20chemotherapy%20solution%20without%20any%20risk%20for%20the%20patient%20during%20RDD%20or%20the%20health%20care%20worker%20due%20to%20accidental%20chemotherapy%20exposure.%20We%20developed%20an%20infusion%20tree%20construction%20that%20allows%20flushing%20the%20lines%20with%20the%20chemotherapy%20solutions%20and%20subsequently%20administering%20RDD%20treatment%20without%20interruption%20or%20risk%20of%20accidental%20exposure%20(see%20Figure%20E1%20in%20this%20article's%20Online%20Repository%20at%20www.jaci-inpractice.org).%20Chemotherapy%20solutions%2C%20neutral%20solutions%2C%20and%20an%20empty%20waste%20bag%20are%20connected%20with%20lines%20filled%20with%20a%20neutral%20solution%20in%20a%20closed%20system.%20The%20lines%20are%20then%20flushed%20in%20a%20specific%20sequence%20(see%20Figures%20E1%20and%20E2%20in%20this%20article's%20Online%20Repository%20at%20www.jaci-inpractice.org)%20into%20a%20waste%20bag.%20After%20flushing%20the%20waste%20line%2C%20the%20waste%20bag%20can%20be%20disconnected%20and%20the%20prepared%20closed%20system%20is%20used%20for%20RDD%2C%20starting%20with%20the%20lowest%20concentration%20(solution%201).%20It%20is%20important%20to%20accurately%20measure%20all%20line%20volumes%20and%20follow%20the%20correct%20order%20when%20flushing%20the%20lines%20to%20prevent%20mixing%20of%20solutions%20during%20flushing%20the%20drip%20chamber%20and%20line%2C%20due%20to%20different%20osmolarities.%20The%20effect%20of%20differences%20in%20osmolarities%20is%20insignificant%20for%20most%20chemotherapy%20drugs%20but%20can%20be%20prevented%20by%20flushing%20the%20lines%20with%20a%20higher%20volume%20of%20the%20chemotherapy%20solution.%20In%20our%20clinic%2C%2019%20patients%20have%20undergone%2074%20RDD%20successfully%20using%20this%20technique.%20Download%20.ppsx%20(.14%20MB)%20Help%20with%20ppsx%20files%20FIGURE%20E1Procedure%20of%20flushing%20the%20lines%20with%20the%20chemotherapy%20solutions.%20K%2C%205-%20to%203-way%20stopcock%20(see%20Figure%20E2)%3B%20N%2C%20neutral%20solution%3B%20P%2C%20patient%3B%20W%2C%20waste%20bag%3B%201%2C%20(lowest%20concentration)%20cytostatic%20solution%201%3B%202%2C%20cytostatic%20solution%202%3B%203%2C%20(highest%20concentration)%20cytostatic%20solution%203.%20Download%20.jpg%20(.24%20MB)%20Help%20with%20files%20Figure%20E2A%205-%20to%203-way%20stopcock%20is%20used%20for%20building%20the%20infusion%20tree.%22){kind=link}