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- W3092540997 abstract "Abstract Chromatosomes play a fundamental role in chromatin regulation, but a detailed understanding of their structure is lacking, partially due to their complex dynamics. Using single-molecule DNA unzipping with optical tweezers, we reveal that linker histone interactions with DNA are remarkably extended, with the C-terminal domain binding both DNA linkers as far as ~ ±140 bp from the dyad. In addition to a symmetrical compaction of the nucleosome core governed by globular domain contacts at the dyad, the C-terminal domain compacts the nucleosome’s entry and exit. These interactions are dynamic, exhibiting rapid binding and dissociation, sensitive to phosphorylation of a specific residue, and crucial to determining the symmetry of the chromatosome’s core. Extensive unzipping of the linker DNA, which mimics its invasion by motor proteins, shifts H1 into an asymmetric, off-dyad configuration and triggers nucleosome decompaction, highlighting the plasticity of the chromatosome structure and its potential regulatory role." @default.
- W3092540997 created "2020-10-15" @default.
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- W3092540997 date "2020-10-10" @default.
- W3092540997 modified "2023-09-27" @default.
- W3092540997 title "Extended and dynamic linker histone-DNA interactions control chromatosome compaction" @default.
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- W3092540997 doi "https://doi.org/10.1101/2020.10.10.334474" @default.
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