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- W3092565901 abstract "Nasopharyngeal carcinoma (NPC) is a common cancer in southern China and Taiwan, and radiation therapy combined with or without chemotherapy is its mainstay treatment. Although it is highly sensitive to radiotherapy, local recurrence and distant metastasis remain difficult unsolved problems. In recent years, graphene oxide (GO) has been found to be a promising novel anticancer drug carrier. Here, we present our designed functionalized GO, polyethylene glycol-coated GO (GO-PEG), as a drug carrier, which was loaded with erlotinib and showed promising anticancer effects on NPC cells.The effects of GO-PEG-erlotinib on the proliferation, migration, and invasion of NPC cells were investigated by WST-8 assay, wound healing assay, and invasion assay, respectively. RNA sequencing was conducted and analyzed to determine the molecular mechanisms by which GO-PEG-erlotinib affects NPC cells.Our results showed that GO-PEG-erlotinib reduced NPC cell viability in a dose-dependent manner and also inhibited the migration and invasion of NPC cells. The RNA sequencing revealed several related molecular mechanisms.GO-PEG-erlotinib effectively suppressed NPC cell proliferation, migration, and invasion, likely by several mechanisms. GO-PEG-erlotinib may be a potential therapeutic agent for treating NPC in the future." @default.
- W3092565901 created "2020-10-15" @default.
- W3092565901 creator A5004537785 @default.
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- W3092565901 creator A5048260390 @default.
- W3092565901 creator A5048680974 @default.
- W3092565901 creator A5050543008 @default.
- W3092565901 date "2020-10-01" @default.
- W3092565901 modified "2023-10-12" @default.
- W3092565901 title "<p>Polyethylene Glycol-Coated Graphene Oxide Loaded with Erlotinib as an Effective Therapeutic Agent for Treating Nasopharyngeal Cancer Cells</p>" @default.
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- W3092565901 doi "https://doi.org/10.2147/ijn.s265437" @default.
- W3092565901 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7548234" @default.
- W3092565901 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33116488" @default.
- W3092565901 hasPublicationYear "2020" @default.
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