Matches in SemOpenAlex for { <https://semopenalex.org/work/W3092582004> ?p ?o ?g. }
- W3092582004 endingPage "119028" @default.
- W3092582004 startingPage "119028" @default.
- W3092582004 abstract "Tyrosinase (TYR) is a crucial enzyme in melanin metabolism and catecholamine production, its abnormal overexpression is closely associated with many human diseases involving melanoma cancer, vitiligo, Parkinson's disease and so on. Herein, a dual-signal fluorescence sensing system for monitoring TYR activity is constructed depending on the transformation of blue-green fluorescence emission of copolymer. The developed sensing system is based on TYR catalyzing the hydroxylation of mono-phenol to o-diphenol and the conversion of fluorescence copolymer (FCP) blue emission (430 nm) and green emission (535 nm) in the presence of PEI. In the system, both blue and green emission exhibit a high selectivity and sensitivity (S/B up to 300 and 30 for blue and green emission, respectively) toward TYR in the range from 0.5 to 2.5 U/mL with the detection limit of 0.002 U/mL and 0.06 U/mL, respectively. Additionally, this assay is used to detect TYR in human serum with excellent recovery even at 30% human serum concentrations. Furthermore, it still has been successfully applied to TYR inhibitor screening by taking kojic acid as a model. We believe that our developed sensor has great potential application in TYR-associated disease diagnosis and treatment and drug discovery." @default.
- W3092582004 created "2020-10-15" @default.
- W3092582004 creator A5014632236 @default.
- W3092582004 creator A5039543540 @default.
- W3092582004 creator A5058965019 @default.
- W3092582004 creator A5059575071 @default.
- W3092582004 creator A5062546650 @default.
- W3092582004 creator A5064920433 @default.
- W3092582004 creator A5067296368 @default.
- W3092582004 creator A5070812231 @default.
- W3092582004 creator A5073841042 @default.
- W3092582004 creator A5079711130 @default.
- W3092582004 date "2021-02-01" @default.
- W3092582004 modified "2023-10-16" @default.
- W3092582004 title "Fluorescence copolymer-based dual-signal monitoring tyrosinase activity and its inhibitor screening via blue-green emission transformation" @default.
- W3092582004 cites W1424869519 @default.
- W3092582004 cites W1963848321 @default.
- W3092582004 cites W1974250234 @default.
- W3092582004 cites W2021920427 @default.
- W3092582004 cites W2031493319 @default.
- W3092582004 cites W2054647458 @default.
- W3092582004 cites W2065495079 @default.
- W3092582004 cites W2094997898 @default.
- W3092582004 cites W2154747637 @default.
- W3092582004 cites W2202991628 @default.
- W3092582004 cites W2287012691 @default.
- W3092582004 cites W2322455030 @default.
- W3092582004 cites W2332897967 @default.
- W3092582004 cites W2340129789 @default.
- W3092582004 cites W2460691587 @default.
- W3092582004 cites W2460970920 @default.
- W3092582004 cites W2492395680 @default.
- W3092582004 cites W2564207615 @default.
- W3092582004 cites W2724407422 @default.
- W3092582004 cites W2753927771 @default.
- W3092582004 cites W2757523634 @default.
- W3092582004 cites W2761093273 @default.
- W3092582004 cites W2765507772 @default.
- W3092582004 cites W2766588016 @default.
- W3092582004 cites W2774669078 @default.
- W3092582004 cites W2781719335 @default.
- W3092582004 cites W2783642547 @default.
- W3092582004 cites W2802076314 @default.
- W3092582004 cites W2804763096 @default.
- W3092582004 cites W2805135699 @default.
- W3092582004 cites W2805893152 @default.
- W3092582004 cites W2811220685 @default.
- W3092582004 cites W2862285183 @default.
- W3092582004 cites W2889285843 @default.
- W3092582004 cites W2896519858 @default.
- W3092582004 cites W2897729256 @default.
- W3092582004 cites W2906203849 @default.
- W3092582004 cites W2907109239 @default.
- W3092582004 cites W2914544043 @default.
- W3092582004 cites W2919242331 @default.
- W3092582004 cites W2934444612 @default.
- W3092582004 cites W2941266296 @default.
- W3092582004 cites W2952095843 @default.
- W3092582004 cites W2952132422 @default.
- W3092582004 cites W2966305918 @default.
- W3092582004 cites W2978761918 @default.
- W3092582004 cites W2982738960 @default.
- W3092582004 cites W2995643677 @default.
- W3092582004 cites W3006831574 @default.
- W3092582004 cites W3012769774 @default.
- W3092582004 cites W3016978129 @default.
- W3092582004 cites W3020657162 @default.
- W3092582004 cites W3022833266 @default.
- W3092582004 cites W3025783484 @default.
- W3092582004 cites W2946970370 @default.
- W3092582004 doi "https://doi.org/10.1016/j.saa.2020.119028" @default.
- W3092582004 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33068897" @default.
- W3092582004 hasPublicationYear "2021" @default.
- W3092582004 type Work @default.
- W3092582004 sameAs 3092582004 @default.
- W3092582004 citedByCount "3" @default.
- W3092582004 countsByYear W30925820042022 @default.
- W3092582004 countsByYear W30925820042023 @default.
- W3092582004 crossrefType "journal-article" @default.
- W3092582004 hasAuthorship W3092582004A5014632236 @default.
- W3092582004 hasAuthorship W3092582004A5039543540 @default.
- W3092582004 hasAuthorship W3092582004A5058965019 @default.
- W3092582004 hasAuthorship W3092582004A5059575071 @default.
- W3092582004 hasAuthorship W3092582004A5062546650 @default.
- W3092582004 hasAuthorship W3092582004A5064920433 @default.
- W3092582004 hasAuthorship W3092582004A5067296368 @default.
- W3092582004 hasAuthorship W3092582004A5070812231 @default.
- W3092582004 hasAuthorship W3092582004A5073841042 @default.
- W3092582004 hasAuthorship W3092582004A5079711130 @default.
- W3092582004 hasConcept C107538193 @default.
- W3092582004 hasConcept C119128265 @default.
- W3092582004 hasConcept C121332964 @default.
- W3092582004 hasConcept C181199279 @default.
- W3092582004 hasConcept C185592680 @default.
- W3092582004 hasConcept C203014093 @default.
- W3092582004 hasConcept C2779538156 @default.
- W3092582004 hasConcept C2779980618 @default.
- W3092582004 hasConcept C2781109383 @default.