Matches in SemOpenAlex for { <https://semopenalex.org/work/W3092591536> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W3092591536 abstract "Abstract In vitro dissolution testing conditions that reflect and predict in vivo drug product performance are advantageous, especially for the development of paediatric medicines, as clinical testing in this population is hindered by ethical and technical considerations. The aim of this study was to develop an in vivo predictive dissolution test in order to investigate the impact of medicine co-administration with soft food and drinks on the dissolution performance of a poorly soluble compound. Relevant in vitro dissolution conditions simulating the in vivo gastrointestinal environment of infants were used to establish in vitro - in vivo relationships with corresponding in vivo data. Dissolution studies of montelukast formulations were conducted with mini-paddle apparatus on a two-stage approach: infant fasted-state simulated gastric fluid (Pi-FaSSGF; for 1 h) followed by either infant fasted-state or infant fed-state simulated intestinal fluid (FaSSIF-V2 or Pi-FeSSIF, respectively; for 3 h). The dosing scenarios tested reflected in vivo paediatric administration practices: (i.) direct administration of formulation; (ii.) formulation co-administered with vehicles (formula, milk or applesauce). Drug dissolution was significantly affected by co-administration of the formulation with vehicles compared with after direct administration of the formulation. Montelukast dissolution from the granules was significantly higher under fed-state simulated intestinal conditions in comparison with the fasted state and was predictive of the in vivo performance when the granules are co-administered with milk. This study supports the potential utility of the in vitro biorelevant dissolution approach proposed to predict in vivo formulation performance after co-administration with vehicles, in the paediatric population." @default.
- W3092591536 created "2020-10-15" @default.
- W3092591536 creator A5006700933 @default.
- W3092591536 creator A5041890708 @default.
- W3092591536 creator A5072811095 @default.
- W3092591536 creator A5088214190 @default.
- W3092591536 date "2020-10-01" @default.
- W3092591536 modified "2023-10-03" @default.
- W3092591536 title "In Vivo Predictive Dissolution Testing of Montelukast Sodium Formulations Administered with Drinks and Soft Foods to Infants" @default.
- W3092591536 cites W1605303439 @default.
- W3092591536 cites W1890421635 @default.
- W3092591536 cites W1977428843 @default.
- W3092591536 cites W1992696421 @default.
- W3092591536 cites W1994325899 @default.
- W3092591536 cites W2004844757 @default.
- W3092591536 cites W2015191233 @default.
- W3092591536 cites W2028911506 @default.
- W3092591536 cites W2038462526 @default.
- W3092591536 cites W2061673014 @default.
- W3092591536 cites W2069148373 @default.
- W3092591536 cites W2077656434 @default.
- W3092591536 cites W2087079029 @default.
- W3092591536 cites W2087895854 @default.
- W3092591536 cites W2161590960 @default.
- W3092591536 cites W2209779914 @default.
- W3092591536 cites W2529377461 @default.
- W3092591536 cites W2561261022 @default.
- W3092591536 cites W2612735122 @default.
- W3092591536 cites W2769601732 @default.
- W3092591536 cites W2898460798 @default.
- W3092591536 cites W3037768707 @default.
- W3092591536 doi "https://doi.org/10.1208/s12249-020-01825-7" @default.
- W3092591536 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7554011" @default.
- W3092591536 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33051713" @default.
- W3092591536 hasPublicationYear "2020" @default.
- W3092591536 type Work @default.
- W3092591536 sameAs 3092591536 @default.
- W3092591536 citedByCount "7" @default.
- W3092591536 countsByYear W30925915362021 @default.
- W3092591536 countsByYear W30925915362022 @default.
- W3092591536 crossrefType "journal-article" @default.
- W3092591536 hasAuthorship W3092591536A5006700933 @default.
- W3092591536 hasAuthorship W3092591536A5041890708 @default.
- W3092591536 hasAuthorship W3092591536A5072811095 @default.
- W3092591536 hasAuthorship W3092591536A5088214190 @default.
- W3092591536 hasBestOaLocation W30925915361 @default.
- W3092591536 hasConcept C126322002 @default.
- W3092591536 hasConcept C14029885 @default.
- W3092591536 hasConcept C147789679 @default.
- W3092591536 hasConcept C150903083 @default.
- W3092591536 hasConcept C185592680 @default.
- W3092591536 hasConcept C207001950 @default.
- W3092591536 hasConcept C2776042228 @default.
- W3092591536 hasConcept C2776322731 @default.
- W3092591536 hasConcept C2780035454 @default.
- W3092591536 hasConcept C2781430271 @default.
- W3092591536 hasConcept C43617362 @default.
- W3092591536 hasConcept C71924100 @default.
- W3092591536 hasConcept C86803240 @default.
- W3092591536 hasConcept C88380143 @default.
- W3092591536 hasConcept C98274493 @default.
- W3092591536 hasConceptScore W3092591536C126322002 @default.
- W3092591536 hasConceptScore W3092591536C14029885 @default.
- W3092591536 hasConceptScore W3092591536C147789679 @default.
- W3092591536 hasConceptScore W3092591536C150903083 @default.
- W3092591536 hasConceptScore W3092591536C185592680 @default.
- W3092591536 hasConceptScore W3092591536C207001950 @default.
- W3092591536 hasConceptScore W3092591536C2776042228 @default.
- W3092591536 hasConceptScore W3092591536C2776322731 @default.
- W3092591536 hasConceptScore W3092591536C2780035454 @default.
- W3092591536 hasConceptScore W3092591536C2781430271 @default.
- W3092591536 hasConceptScore W3092591536C43617362 @default.
- W3092591536 hasConceptScore W3092591536C71924100 @default.
- W3092591536 hasConceptScore W3092591536C86803240 @default.
- W3092591536 hasConceptScore W3092591536C88380143 @default.
- W3092591536 hasConceptScore W3092591536C98274493 @default.
- W3092591536 hasFunder F4320320322 @default.
- W3092591536 hasIssue "7" @default.
- W3092591536 hasLocation W30925915361 @default.
- W3092591536 hasLocation W30925915362 @default.
- W3092591536 hasOpenAccess W3092591536 @default.
- W3092591536 hasPrimaryLocation W30925915361 @default.
- W3092591536 hasRelatedWork W2022995595 @default.
- W3092591536 hasRelatedWork W2067672515 @default.
- W3092591536 hasRelatedWork W2096483010 @default.
- W3092591536 hasRelatedWork W2335426701 @default.
- W3092591536 hasRelatedWork W2438771022 @default.
- W3092591536 hasRelatedWork W2574612889 @default.
- W3092591536 hasRelatedWork W2913375316 @default.
- W3092591536 hasRelatedWork W3178107477 @default.
- W3092591536 hasRelatedWork W36491935 @default.
- W3092591536 hasRelatedWork W4281768328 @default.
- W3092591536 hasVolume "21" @default.
- W3092591536 isParatext "false" @default.
- W3092591536 isRetracted "false" @default.
- W3092591536 magId "3092591536" @default.
- W3092591536 workType "article" @default.