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- W3092600805 abstract "Cytoskeleton systems, actin microfilaments, microtubules (MTs) and intermediate filaments (IFs) provide the biomechanical stability and spatial organization in cells. To understand the specific contributions of each cytoskeleton systems to intrinsic properties of spheroids, we've scrutinized the effects of the cytoskeleton perturbants, cytochalasin D (Cyto D), nocodazole (Noc) and withaferin A (WFA) on fusion, spreading on adhesive surface, morphology and biomechanics of chondrospheres (CSs). We confirmed that treatment with Cyto D but not with Noc or WFA severely affected CSs fusion and spreading dynamics and significantly reduced biomechanical properties of cell aggregates. Noc treatment affected spheroids spreading but not the fusion and surprisingly enhanced their stiffness. Vimentin intermediate filaments (VIFs) reorganization affected CSs spreading only. The analysis of all three cytoskeleton systems contribution to spheroids intrinsic properties was performed for the first time." @default.
- W3092600805 created "2020-10-15" @default.
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- W3092600805 date "2020-12-01" @default.
- W3092600805 modified "2023-10-07" @default.
- W3092600805 title "Cytoskeleton systems contribute differently to the functional intrinsic properties of chondrospheres" @default.
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- W3092600805 doi "https://doi.org/10.1016/j.actbio.2020.10.007" @default.
- W3092600805 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33045401" @default.
- W3092600805 hasPublicationYear "2020" @default.
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