Matches in SemOpenAlex for { <https://semopenalex.org/work/W3092607550> ?p ?o ?g. }
- W3092607550 endingPage "101752" @default.
- W3092607550 startingPage "101752" @default.
- W3092607550 abstract "Dysregulated redox signaling and oxidative injury are associated with inflammatory processes and fibrosis. H2O2 generation by NOX4 has been suggested as a key driver in the development of fibrosis and a small molecule drug is under evaluation in clinical trials for idiopathic pulmonary fibrosis and primary biliary cholangitis. Fibrosis is a common complication in Crohn's disease (CD) leading to stricture formation in 35–40% of patients, who require surgical interventions in the absence of therapeutic options. Here we assess NOX4 expression in CD patients with inflammatory or stricturing disease and examine whether loss of NOX4 is beneficial in acute and fibrotic intestinal disease. NOX4 was upregulated in inflamed mucosal tissue of CD and ulcerative colitis (UC) patients, in CD ileal strictures, and in mice with intestinal inflammation. Nox4 deficiency in mice promoted pathogen colonization and exacerbated tissue injury in acute bacterial and chemical colitis. In contrast, in two chronic injury models aberrant tissue remodeling and fibrosis-related gene expression did not differ substantially between Nox4−/− mice and wildtype mice, suggesting that Nox4 is dispensable in TGF-β1-driven intestinal fibrogenesis. While animal models do not recapitulate all the hallmarks of CD fibrosis, the tissue-protective role of Nox4 warrants a cautious approach to pharmacological inhibitors." @default.
- W3092607550 created "2020-10-15" @default.
- W3092607550 creator A5003873222 @default.
- W3092607550 creator A5009101695 @default.
- W3092607550 creator A5015426313 @default.
- W3092607550 creator A5030029299 @default.
- W3092607550 creator A5032098803 @default.
- W3092607550 creator A5040741209 @default.
- W3092607550 creator A5043867481 @default.
- W3092607550 creator A5063281784 @default.
- W3092607550 creator A5071214551 @default.
- W3092607550 creator A5071427341 @default.
- W3092607550 date "2020-10-01" @default.
- W3092607550 modified "2023-10-02" @default.
- W3092607550 title "NADPH oxidase 4 is protective and not fibrogenic in intestinal inflammation" @default.
- W3092607550 cites W1546880496 @default.
- W3092607550 cites W1600180689 @default.
- W3092607550 cites W1867325796 @default.
- W3092607550 cites W1915414038 @default.
- W3092607550 cites W1915485606 @default.
- W3092607550 cites W1966672647 @default.
- W3092607550 cites W1980300527 @default.
- W3092607550 cites W1985508783 @default.
- W3092607550 cites W1989546207 @default.
- W3092607550 cites W1993566444 @default.
- W3092607550 cites W1995717418 @default.
- W3092607550 cites W2005879027 @default.
- W3092607550 cites W2009094657 @default.
- W3092607550 cites W2009931987 @default.
- W3092607550 cites W2020247031 @default.
- W3092607550 cites W2025026333 @default.
- W3092607550 cites W2033147946 @default.
- W3092607550 cites W2049251840 @default.
- W3092607550 cites W2056269088 @default.
- W3092607550 cites W2056852634 @default.
- W3092607550 cites W2067320696 @default.
- W3092607550 cites W2068995760 @default.
- W3092607550 cites W2073878909 @default.
- W3092607550 cites W2079723429 @default.
- W3092607550 cites W2081975963 @default.
- W3092607550 cites W2124445444 @default.
- W3092607550 cites W2130922818 @default.
- W3092607550 cites W2150459982 @default.
- W3092607550 cites W2153292260 @default.
- W3092607550 cites W2153905079 @default.
- W3092607550 cites W2160911117 @default.
- W3092607550 cites W2163472422 @default.
- W3092607550 cites W2225866786 @default.
- W3092607550 cites W2236270374 @default.
- W3092607550 cites W2295081085 @default.
- W3092607550 cites W2367535883 @default.
- W3092607550 cites W2515781598 @default.
- W3092607550 cites W2559823888 @default.
- W3092607550 cites W2560479095 @default.
- W3092607550 cites W2605134373 @default.
- W3092607550 cites W2607250418 @default.
- W3092607550 cites W2610408070 @default.
- W3092607550 cites W2730947161 @default.
- W3092607550 cites W2748512916 @default.
- W3092607550 cites W2760932249 @default.
- W3092607550 cites W2763231015 @default.
- W3092607550 cites W2790475021 @default.
- W3092607550 cites W2799327942 @default.
- W3092607550 cites W2801353980 @default.
- W3092607550 cites W2893942679 @default.
- W3092607550 cites W2894232765 @default.
- W3092607550 cites W2895840982 @default.
- W3092607550 cites W2897474180 @default.
- W3092607550 cites W2901723143 @default.
- W3092607550 cites W2948562352 @default.
- W3092607550 cites W2953603115 @default.
- W3092607550 cites W2956481235 @default.
- W3092607550 cites W2963917196 @default.
- W3092607550 cites W2971678825 @default.
- W3092607550 cites W2976126064 @default.
- W3092607550 cites W879038605 @default.
- W3092607550 cites W985842495 @default.
- W3092607550 doi "https://doi.org/10.1016/j.redox.2020.101752" @default.
- W3092607550 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7567035" @default.
- W3092607550 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33059312" @default.
- W3092607550 hasPublicationYear "2020" @default.
- W3092607550 type Work @default.
- W3092607550 sameAs 3092607550 @default.
- W3092607550 citedByCount "8" @default.
- W3092607550 countsByYear W30926075502021 @default.
- W3092607550 countsByYear W30926075502022 @default.
- W3092607550 countsByYear W30926075502023 @default.
- W3092607550 crossrefType "journal-article" @default.
- W3092607550 hasAuthorship W3092607550A5003873222 @default.
- W3092607550 hasAuthorship W3092607550A5009101695 @default.
- W3092607550 hasAuthorship W3092607550A5015426313 @default.
- W3092607550 hasAuthorship W3092607550A5030029299 @default.
- W3092607550 hasAuthorship W3092607550A5032098803 @default.
- W3092607550 hasAuthorship W3092607550A5040741209 @default.
- W3092607550 hasAuthorship W3092607550A5043867481 @default.
- W3092607550 hasAuthorship W3092607550A5063281784 @default.
- W3092607550 hasAuthorship W3092607550A5071214551 @default.
- W3092607550 hasAuthorship W3092607550A5071427341 @default.