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• W3092615402 abstract "Abstract Wright’s inbreeding coefficient, F ST , is a fundamental measure in population genetics. Assuming a predefined population subdivision, this statistic is classically used to evaluate population structure at a given genomic locus. With large numbers of loci, unsupervised approaches such as principal component analysis (PCA) have, however, become prominent in recent analyses of population structure. In this study, we describe the relationships between Wright’s inbreeding coefficients and PCA for a model of K discrete populations. Our theory provides an equivalent definition of F ST based on the decomposition of the genotype matrix into between and within-population matrices. The average value of Wright’s F ST over all loci included in the genotype matrix can be obtained from the PCA of the between-population matrix. Assuming that a separation condition is fulfilled and for reasonably large data sets, this value of F ST approximates the proportion of genetic variation explained by the first ( K – 1) principal components accurately. The new definition of F ST is useful for computing inbreeding coefficients from surrogate genotypes, for example, obtained after correction of experimental artifacts or after removing adaptive genetic variation associated with environmental variables. The relationships between inbreeding coefficients and the spectrum of the genotype matrix not only allow interpretations of PCA results in terms of population genetic concepts but extend those concepts to population genetic analyses accounting for temporal, geographical and environmental contexts. Author’s summary Principal component analysis (PCA) is the most-frequently used approach to describe population genetic structure from large population genomic data sets. In this study, we show that PCA not only estimates ancestries of sampled individuals, but also computes the average value of Wright’s inbreeding coefficient over the loci included in the genotype matrix. Our result shows that inbreeding coefficients and PCA eigenvalues provide equivalent descriptions of population structure. As a consequence, PCA extends the definition of this coefficient beyond the framework of allelic frequencies. We give examples on how F ST can be computed from ancient DNA samples for which genotypes are corrected for coverage, and in an ecological genomic example where a proportion of genetic variation is explained by environmental variables." @default.
• W3092615402 created "2020-10-15" @default.
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• W3092615402 date "2020-10-09" @default.
• W3092615402 modified "2023-09-26" @default.
• W3092615402 title "A Spectral Theory for Wright’s Inbreeding Coefficients and Related Quantities" @default.
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• W3092615402 doi "https://doi.org/10.1101/2020.10.07.329755" @default.
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