FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3092623710> ?p ?o ?g. }

• W3092623710 endingPage "103475" @default.
• W3092623710 startingPage "103475" @default.
• W3092623710 abstract "The fungal pathogen Pyrenophora teres f. sp. maculata (Ptm), responsible for spot-form of net blotch (SFNB), is currently the most significant disease of barley in Australia and a major disease worldwide. Management of SFNB relies heavily on fungicides and in Australia the demethylase inhibitors (DMIs) predominate. There have been sporadic reports of resistance to DMIs in Ptm but the mechanisms remain obscure. Ptm isolates collected from 1996 to 2019 in Western Australia were tested for fungicide sensitivity levels. Decreased sensitivity to DMIs was observed in isolates collected after 2015. Resistance factors to tebuconazole fell into two classes; moderate resistance (MR; RF 6–11) and high resistance (HR; RFs 30–65). Mutations linked to resistance were detected in the promoter region and coding sequence of the DMI target gene Cyp51A. Solo-LTR insertion elements were found at 5 different locations in the promoter region. Three different non-synonymous mutations encoded an altered protein with a phenylalanine to leucine substitution at position 489, F489L (F495I in the archetype CYP51A of Aspergillus fumigatus). F489L mutations have also been found in DMI-resistant strains of P. teres f. sp. teres. Ptm isolates carrying either a LTR insertion element or a F489L allele displayed the MR1 or MR2 phenotypes, respectively. Isolates carrying both an insertion element and a F489L mutation displayed the HR phenotype. Multiple mechanisms acting both alone and in concert were found to contribute to DMI resistance in Ptm. Moreover, these mutations have emerged repeatedly in Western Australian Ptm populations by a process of parallel evolution." @default.
• W3092623710 created "2020-10-15" @default.
• W3092623710 creator A5002773455 @default.
• W3092623710 creator A5004869121 @default.
• W3092623710 creator A5008578721 @default.
• W3092623710 creator A5017191130 @default.
• W3092623710 creator A5034991276 @default.
• W3092623710 creator A5047444828 @default.
• W3092623710 creator A5076836505 @default.
• W3092623710 creator A5079286091 @default.
• W3092623710 date "2020-12-01" @default.
• W3092623710 modified "2023-10-18" @default.
• W3092623710 title "Parallel evolution of multiple mechanisms for demethylase inhibitor fungicide resistance in the barley pathogen Pyrenophora teres f. sp. maculata" @default.
• W3092623710 cites W1548791360 @default.
• W3092623710 cites W1589451869 @default.
• W3092623710 cites W1792060583 @default.
• W3092623710 cites W1826329655 @default.
• W3092623710 cites W1891588666 @default.
• W3092623710 cites W1946252112 @default.
• W3092623710 cites W1971417891 @default.
• W3092623710 cites W1976913817 @default.
• W3092623710 cites W1979034620 @default.
• W3092623710 cites W1983225412 @default.
• W3092623710 cites W1985190582 @default.
• W3092623710 cites W1988273601 @default.
• W3092623710 cites W1990621121 @default.
• W3092623710 cites W2012790625 @default.
• W3092623710 cites W2013467774 @default.
• W3092623710 cites W2016776135 @default.
• W3092623710 cites W2033868560 @default.
• W3092623710 cites W2033898946 @default.
• W3092623710 cites W2036134170 @default.
• W3092623710 cites W2052829523 @default.
• W3092623710 cites W2055043387 @default.
• W3092623710 cites W2059864757 @default.
• W3092623710 cites W2063512618 @default.
• W3092623710 cites W2073344396 @default.
• W3092623710 cites W2074970525 @default.
• W3092623710 cites W2075793022 @default.
• W3092623710 cites W2075909840 @default.
• W3092623710 cites W2080664297 @default.
• W3092623710 cites W2081981239 @default.
• W3092623710 cites W2084087805 @default.
• W3092623710 cites W2085647931 @default.
• W3092623710 cites W2090757804 @default.
• W3092623710 cites W2091101839 @default.
• W3092623710 cites W2093178404 @default.
• W3092623710 cites W2096420865 @default.
• W3092623710 cites W2100048219 @default.
• W3092623710 cites W2100311116 @default.
• W3092623710 cites W2101112015 @default.
• W3092623710 cites W2102332954 @default.
• W3092623710 cites W2104021702 @default.
• W3092623710 cites W2106882534 @default.
• W3092623710 cites W2107277218 @default.
• W3092623710 cites W2108581564 @default.
• W3092623710 cites W2113498073 @default.
• W3092623710 cites W2115118709 @default.
• W3092623710 cites W2119139579 @default.
• W3092623710 cites W2120654097 @default.
• W3092623710 cites W2132960741 @default.
• W3092623710 cites W2134057221 @default.
• W3092623710 cites W2136411460 @default.
• W3092623710 cites W2136655360 @default.
• W3092623710 cites W2142912010 @default.
• W3092623710 cites W2163894954 @default.
• W3092623710 cites W2170186541 @default.
• W3092623710 cites W2170970303 @default.
• W3092623710 cites W2258928300 @default.
• W3092623710 cites W2293665288 @default.
• W3092623710 cites W2296193806 @default.
• W3092623710 cites W2345741290 @default.
• W3092623710 cites W2345747102 @default.
• W3092623710 cites W2410616080 @default.
• W3092623710 cites W2504810752 @default.
• W3092623710 cites W2510097428 @default.
• W3092623710 cites W2513530705 @default.
• W3092623710 cites W2587857020 @default.
• W3092623710 cites W2611735579 @default.
• W3092623710 cites W2737096583 @default.
• W3092623710 cites W2744893847 @default.
• W3092623710 cites W2767215479 @default.
• W3092623710 cites W2789715412 @default.
• W3092623710 cites W2792274828 @default.
• W3092623710 cites W2800496546 @default.
• W3092623710 cites W2810473995 @default.
• W3092623710 cites W2905188465 @default.
• W3092623710 cites W2952903368 @default.
• W3092623710 cites W85250378 @default.
• W3092623710 doi "https://doi.org/10.1016/j.fgb.2020.103475" @default.
• W3092623710 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33035658" @default.
• W3092623710 hasPublicationYear "2020" @default.
• W3092623710 type Work @default.
• W3092623710 sameAs 3092623710 @default.
• W3092623710 citedByCount "16" @default.
• W3092623710 countsByYear W30926237102021 @default.
• W3092623710 countsByYear W30926237102022 @default.
• W3092623710 countsByYear W30926237102023 @default.

• next