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• W3092623763 startingPage "125908" @default.
• W3092623763 abstract "Monodisperse emulsions of solvent saturated with the active pharmaceutical ingredient (API) cabotegravir were generated by microfluidic devices. In contrast to model oil-water emulsions that provide idealized conditions for obtaining highly monodisperse emulsions, APIs impart strict limitations on solvent choice. To provide a suitable environment in which extractive crystallization could occur, and to enhance reproducibility, co-solvents were introduced. Subsequently, the effect of each solvent component on morphology and size was observed. Through the manipulation of solvent composition, particles of both plate-like and spherical multi-crystal agglomerates were obtained, providing the ability to tune the operating conditions to provide particles with desirable characteristics such as size, shape and flowability. Scale-up of the manufacturing process was addressed through the application of existing microfluidic parallelization techniques, resulting in a 100-fold increase in throughput over a single-channel device. Subsequently, the obtained pure, and excipient-bound, API spherical agglomerates, were subjected to batch isolation and washing." @default.
• W3092623763 created "2020-10-15" @default.
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• W3092623763 date "2020-12-01" @default.
• W3092623763 modified "2023-09-27" @default.
• W3092623763 title "Extractive crystallization of cabotegravir in droplet-based microfluidic devices" @default.
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• W3092623763 doi "https://doi.org/10.1016/j.jcrysgro.2020.125908" @default.
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