Matches in SemOpenAlex for { <https://semopenalex.org/work/W3092631627> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W3092631627 endingPage "150" @default.
- W3092631627 startingPage "143" @default.
- W3092631627 abstract "Flow cytometric immunophenotyping (FCI) plays a major role in diagnosing hematologic malignancies. In patients diagnosed with precursor B-lineage acute lymphoblastic leukemia (B-ALL), expression of certain non-lineage/cross lineage antigens is of prognostic and cytogenetic relevance. There is a paucity of studies that have comprehensively analyzed the clinical and laboratory profiles of B-ALL patients showing aberrant T/natural killer (NK) cell antigen expression.This is a prospective study where 152 consecutive B-ALL patients were analyzed for aberrant expression of T/NK cell antigens (CD1a, CD5, CD4, CD7, CD8 and CD56) by FCI. The clinical and laboratory profile of these T/NK-cell antigen-expressing B-ALL patients was statistically analyzed against conventional B-ALL patients.In our B-ALL cohort, CD5, CD7 and CD56 expression were observed in one, six and nine patients, respectively. CD56-expressing B-ALL patients were predominantly children (89%) and presented as standard clinical risk (p=0.010) disease with frequent ETV6-RUNX1 fusion (p=0.021) positivity. On the contrary, CD7-expressing B-ALL patients were adolescent-young adult/adult-age skewed (83%) and had an adverse cytogenetic profile (p=0.001), especially for the frequent presence of BCR-ABL1 fusion (p=0.004) and KMT2A rearrangement (p=0.045). CD7-expressing B-ALL patients had inferior event-free survival (p=0.040) than their CD56-expressing counterparts, but there was no significant difference in the overall survival (p=0.317).In comparison to conventional B-ALL patients, there are significant differences in the age, cytogenetic profile and event-free survival of T/NK-cell antigen-expressing B-ALL patients." @default.
- W3092631627 created "2020-10-15" @default.
- W3092631627 creator A5002149046 @default.
- W3092631627 creator A5002151585 @default.
- W3092631627 creator A5005584060 @default.
- W3092631627 creator A5039441410 @default.
- W3092631627 creator A5061727601 @default.
- W3092631627 creator A5077018089 @default.
- W3092631627 creator A5085008874 @default.
- W3092631627 date "2022-04-01" @default.
- W3092631627 modified "2023-10-01" @default.
- W3092631627 title "Precursor B-lineage acute lymphoblastic leukemia patients with aberrant natural killer cell and T cell – lineage antigen expression: experience from a tertiary cancer care center" @default.
- W3092631627 cites W1607999619 @default.
- W3092631627 cites W1964880561 @default.
- W3092631627 cites W1971919922 @default.
- W3092631627 cites W1975979722 @default.
- W3092631627 cites W1985789061 @default.
- W3092631627 cites W1991685226 @default.
- W3092631627 cites W1996849272 @default.
- W3092631627 cites W2015717456 @default.
- W3092631627 cites W2025092889 @default.
- W3092631627 cites W2042049887 @default.
- W3092631627 cites W2048011268 @default.
- W3092631627 cites W2101591778 @default.
- W3092631627 cites W2125887034 @default.
- W3092631627 cites W2324055460 @default.
- W3092631627 cites W2331424793 @default.
- W3092631627 cites W2401557260 @default.
- W3092631627 cites W2531377192 @default.
- W3092631627 cites W2768313876 @default.
- W3092631627 cites W2895568978 @default.
- W3092631627 cites W2953331326 @default.
- W3092631627 cites W2983569261 @default.
- W3092631627 doi "https://doi.org/10.1016/j.htct.2020.08.012" @default.
- W3092631627 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33526373" @default.
- W3092631627 hasPublicationYear "2022" @default.
- W3092631627 type Work @default.
- W3092631627 sameAs 3092631627 @default.
- W3092631627 citedByCount "2" @default.
- W3092631627 countsByYear W30926316272022 @default.
- W3092631627 countsByYear W30926316272023 @default.
- W3092631627 crossrefType "journal-article" @default.
- W3092631627 hasAuthorship W3092631627A5002149046 @default.
- W3092631627 hasAuthorship W3092631627A5002151585 @default.
- W3092631627 hasAuthorship W3092631627A5005584060 @default.
- W3092631627 hasAuthorship W3092631627A5039441410 @default.
- W3092631627 hasAuthorship W3092631627A5061727601 @default.
- W3092631627 hasAuthorship W3092631627A5077018089 @default.
- W3092631627 hasAuthorship W3092631627A5085008874 @default.
- W3092631627 hasBestOaLocation W30926316271 @default.
- W3092631627 hasConcept C113067387 @default.
- W3092631627 hasConcept C126322002 @default.
- W3092631627 hasConcept C143998085 @default.
- W3092631627 hasConcept C147483822 @default.
- W3092631627 hasConcept C196166836 @default.
- W3092631627 hasConcept C203014093 @default.
- W3092631627 hasConcept C71924100 @default.
- W3092631627 hasConcept C86803240 @default.
- W3092631627 hasConceptScore W3092631627C113067387 @default.
- W3092631627 hasConceptScore W3092631627C126322002 @default.
- W3092631627 hasConceptScore W3092631627C143998085 @default.
- W3092631627 hasConceptScore W3092631627C147483822 @default.
- W3092631627 hasConceptScore W3092631627C196166836 @default.
- W3092631627 hasConceptScore W3092631627C203014093 @default.
- W3092631627 hasConceptScore W3092631627C71924100 @default.
- W3092631627 hasConceptScore W3092631627C86803240 @default.
- W3092631627 hasIssue "2" @default.
- W3092631627 hasLocation W30926316271 @default.
- W3092631627 hasLocation W30926316272 @default.
- W3092631627 hasLocation W30926316273 @default.
- W3092631627 hasOpenAccess W3092631627 @default.
- W3092631627 hasPrimaryLocation W30926316271 @default.
- W3092631627 hasRelatedWork W1995362916 @default.
- W3092631627 hasRelatedWork W2079637159 @default.
- W3092631627 hasRelatedWork W2353714056 @default.
- W3092631627 hasRelatedWork W2355327155 @default.
- W3092631627 hasRelatedWork W2355904922 @default.
- W3092631627 hasRelatedWork W2356643487 @default.
- W3092631627 hasRelatedWork W2369926714 @default.
- W3092631627 hasRelatedWork W2378707818 @default.
- W3092631627 hasRelatedWork W2388511227 @default.
- W3092631627 hasRelatedWork W3141004474 @default.
- W3092631627 hasVolume "44" @default.
- W3092631627 isParatext "false" @default.
- W3092631627 isRetracted "false" @default.
- W3092631627 magId "3092631627" @default.
- W3092631627 workType "article" @default.