FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3092645135> ?p ?o ?g. }

• W3092645135 abstract "In spite of intensive treatment Type 1 diabetes leads to serious complications. Preservation of residual beta cell function makes the disease milder, facilitates treatment, prevents complications and increase survival. So far immune interventions have had limited effect, and some serious adverse events and risks. In an open pilot trial we aimed to improve efficacy of GAD-alum treatment using lymph-node administration in combination with oral vitamin D. Here we report the clinical effect and focus on biomarkers for response to treatment. Patients (n=12) aged 12-24 years with recent onset of Type 1 diabetes received 4 μg GAD-alum into lymph-node at day 30, 60, and 90, and oral Vitamin D 2000 U/d, day 1-120. Beta cell function was estimated by Mixed Meal Tolerance Tests. GADA, GADA subclasses, GAD65-induced cytokines and proliferation, and T cells markers were analyzed. The treatment was tolerable with no adverse events. Fasting C-peptide and insulin requirement remained stable at 15 months, while HbA1c was lower than baseline. Stimulated C-peptide showed no change at 6 months but declined after 15 months (81% of baseline). Eleven patients remained in partial remission (IDAAC < 9). Patients (n=9) with better clinical outcome had reduced proportion of IgG1 and increased IgG2, IgG3, and IgG4, increased IL-10 secretion, and reduction of proliferation and CD8+ T cells activation. Patients with poorer clinical response had higher baseline levels of GAD65-induced cytokines and T-cell activation, and an increased ratio of effector/central memory T cells. Intra-lymphatic GAD treatment combined with Vitamin D might preserve beta cell function and improve clinical course in T1D. Patients with less benefit have a different quality of immune response both before and after treatment. Trial Registration: NCT02352974, clinicaltrials.gov" @default.
• W3092645135 created "2020-10-15" @default.
• W3092645135 creator A5020615799 @default.
• W3092645135 creator A5028741505 @default.
• W3092645135 creator A5043420399 @default.
• W3092645135 creator A5048395719 @default.
• W3092645135 creator A5057383644 @default.
• W3092645135 creator A5075539164 @default.
• W3092645135 creator A5075567727 @default.
• W3092645135 date "2020-10-09" @default.
• W3092645135 modified "2023-10-10" @default.
• W3092645135 title "Glutamic Acid Decarboxylase Injection Into Lymph Nodes: Beta Cell Function and Immune Responses in Recent Onset Type 1 Diabetes Patients" @default.
• W3092645135 cites W1978212347 @default.
• W3092645135 cites W2003114458 @default.
• W3092645135 cites W2021678927 @default.
• W3092645135 cites W2024693050 @default.
• W3092645135 cites W2041637201 @default.
• W3092645135 cites W2046620531 @default.
• W3092645135 cites W2059593985 @default.
• W3092645135 cites W2093011834 @default.
• W3092645135 cites W2096862996 @default.
• W3092645135 cites W2098954537 @default.
• W3092645135 cites W2113847305 @default.
• W3092645135 cites W2114603595 @default.
• W3092645135 cites W2118174270 @default.
• W3092645135 cites W2140340166 @default.
• W3092645135 cites W2142623432 @default.
• W3092645135 cites W2143290550 @default.
• W3092645135 cites W2146359593 @default.
• W3092645135 cites W2146664729 @default.
• W3092645135 cites W2156964052 @default.
• W3092645135 cites W2162000478 @default.
• W3092645135 cites W2163626160 @default.
• W3092645135 cites W2168938667 @default.
• W3092645135 cites W2210526835 @default.
• W3092645135 cites W2496355899 @default.
• W3092645135 cites W2525595583 @default.
• W3092645135 cites W2528836831 @default.
• W3092645135 cites W2588222833 @default.
• W3092645135 cites W2789874777 @default.
• W3092645135 cites W2804111235 @default.
• W3092645135 cites W2898408097 @default.
• W3092645135 cites W2898492815 @default.
• W3092645135 cites W2940004630 @default.
• W3092645135 cites W3036106596 @default.
• W3092645135 doi "https://doi.org/10.3389/fimmu.2020.564921" @default.
• W3092645135 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7583358" @default.
• W3092645135 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33162978" @default.
• W3092645135 hasPublicationYear "2020" @default.
• W3092645135 type Work @default.
• W3092645135 sameAs 3092645135 @default.
• W3092645135 citedByCount "15" @default.
• W3092645135 countsByYear W30926451352021 @default.
• W3092645135 countsByYear W30926451352022 @default.
• W3092645135 countsByYear W30926451352023 @default.
• W3092645135 crossrefType "journal-article" @default.
• W3092645135 hasAuthorship W3092645135A5020615799 @default.
• W3092645135 hasAuthorship W3092645135A5028741505 @default.
• W3092645135 hasAuthorship W3092645135A5043420399 @default.
• W3092645135 hasAuthorship W3092645135A5048395719 @default.
• W3092645135 hasAuthorship W3092645135A5057383644 @default.
• W3092645135 hasAuthorship W3092645135A5075539164 @default.
• W3092645135 hasAuthorship W3092645135A5075567727 @default.
• W3092645135 hasBestOaLocation W30926451351 @default.
• W3092645135 hasConcept C126322002 @default.
• W3092645135 hasConcept C134018914 @default.
• W3092645135 hasConcept C167672396 @default.
• W3092645135 hasConcept C197934379 @default.
• W3092645135 hasConcept C203014093 @default.
• W3092645135 hasConcept C2776090121 @default.
• W3092645135 hasConcept C2777180221 @default.
• W3092645135 hasConcept C2780849966 @default.
• W3092645135 hasConcept C2781232474 @default.
• W3092645135 hasConcept C555293320 @default.
• W3092645135 hasConcept C71924100 @default.
• W3092645135 hasConcept C8891405 @default.
• W3092645135 hasConcept C90924648 @default.
• W3092645135 hasConceptScore W3092645135C126322002 @default.
• W3092645135 hasConceptScore W3092645135C134018914 @default.
• W3092645135 hasConceptScore W3092645135C167672396 @default.
• W3092645135 hasConceptScore W3092645135C197934379 @default.
• W3092645135 hasConceptScore W3092645135C203014093 @default.
• W3092645135 hasConceptScore W3092645135C2776090121 @default.
• W3092645135 hasConceptScore W3092645135C2777180221 @default.
• W3092645135 hasConceptScore W3092645135C2780849966 @default.
• W3092645135 hasConceptScore W3092645135C2781232474 @default.
• W3092645135 hasConceptScore W3092645135C555293320 @default.
• W3092645135 hasConceptScore W3092645135C71924100 @default.
• W3092645135 hasConceptScore W3092645135C8891405 @default.
• W3092645135 hasConceptScore W3092645135C90924648 @default.
• W3092645135 hasFunder F4320322225 @default.
• W3092645135 hasLocation W30926451351 @default.
• W3092645135 hasLocation W30926451352 @default.
• W3092645135 hasLocation W30926451353 @default.
• W3092645135 hasOpenAccess W3092645135 @default.
• W3092645135 hasPrimaryLocation W30926451351 @default.
• W3092645135 hasRelatedWork W1490833013 @default.
• W3092645135 hasRelatedWork W1572148375 @default.
• W3092645135 hasRelatedWork W1980400007 @default.
• W3092645135 hasRelatedWork W2020684972 @default.

• next