FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W309267999> ?p ?o ?g. }

• W309267999 abstract "Abstract We studied the effect of tumor necrosis factor (TNF) and gamma interferon (IFN-gamma), alone and in combination, on the expression of chemotactic peptide receptors, stimulus-induced actin polymerization, hydrogen peroxide production (H2O2), and expression of nonspecific esterase (NSE) positivity in human promyelocytic leukemic cell line HL- 60. These parameters were analyzed following a five-day culture with the cytokines. Chemotactic peptide receptor expression was studied using the fluoresceinated hexapeptide, formyl-norleucyl-leucyl- phenylalanyl-norleucyl-tyrosyl-lysine and flow cytometry. Actin polymerization, an important event required for chemotaxis and phagocytosis, was studied using NBD-phallacidin labeling, following stimulation with the chemotactic peptide formyl-methionyl-leucyl- phenylalanine (FMLP) or phorbol myristate acetate (PMA). TNF increased the expression of chemotactic peptide receptors in a dose-dependent fashion, and there was good correlation between the receptor expression, stimulus-induced actin polymerization, H2O2 production, and NSE positivity. IFN-gamma was less potent in inducing all the parameters studied but exerted a positive cooperative effect when combined with TNF. IFN-gamma at high concentrations induced chemotactic peptide receptors comparable in magnitude to that seen with TNF but failed to prime these cells to undergo actin polymerization in response to FMLP or PMA. Undifferentiated HL-60 cells showed a decrease in F- actin content on stimulation with PMA. This suggests that protein kinase C might have a negative regulatory role in stimulus-induced actin polymerization. The observations reported here indicate that appropriate combinations of different inducing agents with different modes of action might be necessary to duplicate the functional abilities of mature phagocytic cells." @default.
• W309267999 created "2016-06-24" @default.
• W309267999 creator A5003798770 @default.
• W309267999 creator A5007388681 @default.
• W309267999 creator A5057623456 @default.
• W309267999 creator A5084238289 @default.
• W309267999 date "1988-04-01" @default.
• W309267999 modified "2023-09-29" @default.
• W309267999 title "Cooperative effect of tumor necrosis factor and gamma-interferon on chemotactic peptide receptor expression and stimulus-induced actin polymerization in HL-60 cells" @default.
• W309267999 cites W124753632 @default.
• W309267999 cites W1482066779 @default.
• W309267999 cites W1507635013 @default.
• W309267999 cites W1530752901 @default.
• W309267999 cites W1564176844 @default.
• W309267999 cites W1594641025 @default.
• W309267999 cites W1656963224 @default.
• W309267999 cites W1678649710 @default.
• W309267999 cites W1779409385 @default.
• W309267999 cites W2010113650 @default.
• W309267999 cites W2012850596 @default.
• W309267999 cites W2016951403 @default.
• W309267999 cites W2019356834 @default.
• W309267999 cites W2026241835 @default.
• W309267999 cites W2031043501 @default.
• W309267999 cites W2044965263 @default.
• W309267999 cites W2048962185 @default.
• W309267999 cites W2067917571 @default.
• W309267999 cites W2075813138 @default.
• W309267999 cites W2081910096 @default.
• W309267999 cites W2126808921 @default.
• W309267999 cites W2137736246 @default.
• W309267999 cites W2140769991 @default.
• W309267999 cites W2177562606 @default.
• W309267999 cites W2295511676 @default.
• W309267999 cites W2402387760 @default.
• W309267999 cites W2409578040 @default.
• W309267999 cites W2418345715 @default.
• W309267999 cites W2418599198 @default.
• W309267999 cites W40933246 @default.
• W309267999 doi "https://doi.org/10.1182/blood.v71.4.1062.1062" @default.
• W309267999 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3128345" @default.
• W309267999 hasPublicationYear "1988" @default.
• W309267999 type Work @default.
• W309267999 sameAs 309267999 @default.
• W309267999 citedByCount "20" @default.
• W309267999 crossrefType "journal-article" @default.
• W309267999 hasAuthorship W309267999A5003798770 @default.
• W309267999 hasAuthorship W309267999A5007388681 @default.
• W309267999 hasAuthorship W309267999A5057623456 @default.
• W309267999 hasAuthorship W309267999A5084238289 @default.
• W309267999 hasBestOaLocation W3092679991 @default.
• W309267999 hasConcept C134018914 @default.
• W309267999 hasConcept C153911025 @default.
• W309267999 hasConcept C170493617 @default.
• W309267999 hasConcept C17991360 @default.
• W309267999 hasConcept C185592680 @default.
• W309267999 hasConcept C2780656570 @default.
• W309267999 hasConcept C54166955 @default.
• W309267999 hasConcept C55493867 @default.
• W309267999 hasConcept C86803240 @default.
• W309267999 hasConcept C95444343 @default.
• W309267999 hasConceptScore W309267999C134018914 @default.
• W309267999 hasConceptScore W309267999C153911025 @default.
• W309267999 hasConceptScore W309267999C170493617 @default.
• W309267999 hasConceptScore W309267999C17991360 @default.
• W309267999 hasConceptScore W309267999C185592680 @default.
• W309267999 hasConceptScore W309267999C2780656570 @default.
• W309267999 hasConceptScore W309267999C54166955 @default.
• W309267999 hasConceptScore W309267999C55493867 @default.
• W309267999 hasConceptScore W309267999C86803240 @default.
• W309267999 hasConceptScore W309267999C95444343 @default.
• W309267999 hasLocation W3092679991 @default.
• W309267999 hasOpenAccess W309267999 @default.
• W309267999 hasPrimaryLocation W3092679991 @default.
• W309267999 hasRelatedWork W1936130648 @default.
• W309267999 hasRelatedWork W1981150151 @default.
• W309267999 hasRelatedWork W2002216168 @default.
• W309267999 hasRelatedWork W2009932700 @default.
• W309267999 hasRelatedWork W2026357881 @default.
• W309267999 hasRelatedWork W2034948050 @default.
• W309267999 hasRelatedWork W2044444770 @default.
• W309267999 hasRelatedWork W2047063876 @default.
• W309267999 hasRelatedWork W2065311537 @default.
• W309267999 hasRelatedWork W2079746485 @default.
• W309267999 hasRelatedWork W2102438459 @default.
• W309267999 hasRelatedWork W2130580722 @default.
• W309267999 hasRelatedWork W2184562399 @default.
• W309267999 hasRelatedWork W2188281272 @default.
• W309267999 hasRelatedWork W2414183835 @default.
• W309267999 hasRelatedWork W2416641196 @default.
• W309267999 hasRelatedWork W2438201618 @default.
• W309267999 hasRelatedWork W313760318 @default.
• W309267999 hasRelatedWork W324877291 @default.
• W309267999 hasRelatedWork W89707886 @default.
• W309267999 isParatext "false" @default.
• W309267999 isRetracted "false" @default.
• W309267999 magId "309267999" @default.
• W309267999 workType "article" @default.