Matches in SemOpenAlex for { <https://semopenalex.org/work/W3092689949> ?p ?o ?g. }
- W3092689949 endingPage "2583" @default.
- W3092689949 startingPage "2563" @default.
- W3092689949 abstract "Aim: This study aims to load tamoxifen (TAM) and sulforaphane (SFN) into nanostructured lipid carriers (NLCs) to enhance their oral delivery. Materials & methods: TAM-SFN-NLCs were prepared using Precirol ® ATO5 and Transcutol ® HP, characterized and evaluated in vitro and ex vivo to assess the drug release profile and intestinal permeability, respectively. In vivo pharmacokinetic and acute toxicity assessment was performed in Wistar rats. Results: Optimized TAM-SFN-NLCs exhibited a particle size of 121.9 ± 6.42 nm and zeta potential of -21.2 ± 2.91 mV. The NLCs enhanced intestinal permeability of TAM and SFN and augmented oral bioavailability of TAM and SFN 5.2-fold and 4.8-fold, respectively. SFN significantly reduced TAM-associated toxicity in vivo. Conclusion: This coencapsulation of a chemotherapeutic agent with a herbal bioactive in NLCs could pave a novel treatment approach against cancer." @default.
- W3092689949 created "2020-10-22" @default.
- W3092689949 creator A5026047862 @default.
- W3092689949 creator A5046983034 @default.
- W3092689949 creator A5048038480 @default.
- W3092689949 creator A5053918269 @default.
- W3092689949 creator A5063264752 @default.
- W3092689949 creator A5085771499 @default.
- W3092689949 date "2020-11-01" @default.
- W3092689949 modified "2023-10-01" @default.
- W3092689949 title "Lipid-nanopotentiated combinatorial delivery of tamoxifen and sulforaphane: <i>ex vivo</i>, <i>in vivo</i> and toxicity studies" @default.
- W3092689949 cites W1241822319 @default.
- W3092689949 cites W1730454732 @default.
- W3092689949 cites W1944910512 @default.
- W3092689949 cites W1999134373 @default.
- W3092689949 cites W2005957565 @default.
- W3092689949 cites W2012100899 @default.
- W3092689949 cites W2040095473 @default.
- W3092689949 cites W2048256263 @default.
- W3092689949 cites W2054458894 @default.
- W3092689949 cites W2059757184 @default.
- W3092689949 cites W2063634819 @default.
- W3092689949 cites W2073983855 @default.
- W3092689949 cites W2075081697 @default.
- W3092689949 cites W2078768792 @default.
- W3092689949 cites W2082660441 @default.
- W3092689949 cites W2086380903 @default.
- W3092689949 cites W2100195057 @default.
- W3092689949 cites W2100520064 @default.
- W3092689949 cites W2110831416 @default.
- W3092689949 cites W2114190473 @default.
- W3092689949 cites W2133207329 @default.
- W3092689949 cites W2147631083 @default.
- W3092689949 cites W2151453570 @default.
- W3092689949 cites W2161051443 @default.
- W3092689949 cites W2162047323 @default.
- W3092689949 cites W2174489205 @default.
- W3092689949 cites W2191912059 @default.
- W3092689949 cites W2236933518 @default.
- W3092689949 cites W2237126041 @default.
- W3092689949 cites W2319297004 @default.
- W3092689949 cites W2332771410 @default.
- W3092689949 cites W2532272712 @default.
- W3092689949 cites W2540269711 @default.
- W3092689949 cites W2563958965 @default.
- W3092689949 cites W2585655283 @default.
- W3092689949 cites W2586461404 @default.
- W3092689949 cites W2593985050 @default.
- W3092689949 cites W2623676679 @default.
- W3092689949 cites W2731620928 @default.
- W3092689949 cites W2765842496 @default.
- W3092689949 cites W2777726914 @default.
- W3092689949 cites W2789432698 @default.
- W3092689949 cites W2791777845 @default.
- W3092689949 cites W2800752654 @default.
- W3092689949 cites W2803001759 @default.
- W3092689949 cites W2807563738 @default.
- W3092689949 cites W2807734632 @default.
- W3092689949 cites W2838017814 @default.
- W3092689949 cites W2883290340 @default.
- W3092689949 cites W2886457623 @default.
- W3092689949 cites W2889300357 @default.
- W3092689949 cites W2898312022 @default.
- W3092689949 cites W2900637971 @default.
- W3092689949 cites W2904572694 @default.
- W3092689949 cites W2936858823 @default.
- W3092689949 cites W2950055141 @default.
- W3092689949 cites W2969990947 @default.
- W3092689949 cites W2971173084 @default.
- W3092689949 cites W2981382897 @default.
- W3092689949 cites W2985331830 @default.
- W3092689949 cites W3004806453 @default.
- W3092689949 cites W3040011780 @default.
- W3092689949 cites W3049084882 @default.
- W3092689949 cites W365185848 @default.
- W3092689949 cites W369680060 @default.
- W3092689949 doi "https://doi.org/10.2217/nnm-2020-0277" @default.
- W3092689949 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33079004" @default.
- W3092689949 hasPublicationYear "2020" @default.
- W3092689949 type Work @default.
- W3092689949 sameAs 3092689949 @default.
- W3092689949 citedByCount "24" @default.
- W3092689949 countsByYear W30926899492021 @default.
- W3092689949 countsByYear W30926899492022 @default.
- W3092689949 countsByYear W30926899492023 @default.
- W3092689949 crossrefType "journal-article" @default.
- W3092689949 hasAuthorship W3092689949A5026047862 @default.
- W3092689949 hasAuthorship W3092689949A5046983034 @default.
- W3092689949 hasAuthorship W3092689949A5048038480 @default.
- W3092689949 hasAuthorship W3092689949A5053918269 @default.
- W3092689949 hasAuthorship W3092689949A5063264752 @default.
- W3092689949 hasAuthorship W3092689949A5085771499 @default.
- W3092689949 hasConcept C112705442 @default.
- W3092689949 hasConcept C150903083 @default.
- W3092689949 hasConcept C155672457 @default.
- W3092689949 hasConcept C171250308 @default.
- W3092689949 hasConcept C178790620 @default.
- W3092689949 hasConcept C181389837 @default.