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• W3092691657 abstract "Hypoxia is related to a variety of diseases, such as cardiovascular and inflammatory diseases and various cancers. Telomere length (TL) may vary according to the hypoxia level and cell types. To the best of our knowledge, no study has investigated the effect of moderate hypoxia on TL and mitochondrial DNA copy number (mtDNAcn) in human lymphocytes. Therefore, in this study, we analyzed the effect of moderate hypoxia on TL in correlation with mtDNAcn. This study included 32 healthy male nonsmoker’s subjects; in this cohort, we had previously studied sister chromatid exchange and microsatellite instability. Blood samples from each subject were divided into three groups: a control group and two experimental groups exposed to moderate hypoxia for 12 or 24 h. Relative TL and mtDNAcn were measured by a quantitative real-time polymerase chain reaction. The TL in the control group did not significantly differ from that in the experimental group subjected to hypoxia for 12 h; however, the TL in the 24 h hypoxia–treated experimental group was significantly higher than that in the control group. The correlation between TL and mtDNAcn was not statistically significant in the two hypoxic states. The increase in TL was observed on exposure to hypoxia for 24 h and not for 12 h; thus, the findings suggest that telomere elongation is related to hypoxia exposure duration. The mtDNAcn in the two experimental groups did not significantly differ from that in the control group. These observations suggest that mtDNAcn alterations show more genetic stability than TL alterations. To the best of our knowledge, this is the first in vitro study on human lymphocytes reporting an increase in TL and no alteration in mtDNAcn after short-time exposure to moderate hypoxia." @default.
• W3092691657 created "2020-10-22" @default.
• W3092691657 creator A5048029825 @default.
• W3092691657 creator A5050388611 @default.
• W3092691657 date "2020-01-01" @default.
• W3092691657 modified "2023-10-11" @default.
• W3092691657 title "Alterations in telomere length and mitochondrial DNA copy number in human lymphocytes on short-term exposure to moderate hypoxia" @default.
• W3092691657 cites W1903290798 @default.
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• W3092691657 cites W1970548725 @default.
• W3092691657 cites W1972959373 @default.
• W3092691657 cites W1985380538 @default.
• W3092691657 cites W1988641927 @default.
• W3092691657 cites W1998150842 @default.
• W3092691657 cites W1999054014 @default.
• W3092691657 cites W1999872096 @default.
• W3092691657 cites W2010406601 @default.
• W3092691657 cites W2014013625 @default.
• W3092691657 cites W2021250915 @default.
• W3092691657 cites W2023806404 @default.
• W3092691657 cites W2028938051 @default.
• W3092691657 cites W2031811366 @default.
• W3092691657 cites W2033559853 @default.
• W3092691657 cites W2050744615 @default.
• W3092691657 cites W2052066518 @default.
• W3092691657 cites W2055494288 @default.
• W3092691657 cites W2065239370 @default.
• W3092691657 cites W2066976215 @default.
• W3092691657 cites W2067557887 @default.
• W3092691657 cites W2069245286 @default.
• W3092691657 cites W2070618839 @default.
• W3092691657 cites W2079167667 @default.
• W3092691657 cites W2091260936 @default.
• W3092691657 cites W2093091913 @default.
• W3092691657 cites W2094071170 @default.
• W3092691657 cites W2097529540 @default.
• W3092691657 cites W2098379861 @default.
• W3092691657 cites W2098902167 @default.
• W3092691657 cites W2100702324 @default.
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• W3092691657 cites W2126763338 @default.
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• W3092691657 cites W2129896687 @default.
• W3092691657 cites W2137465719 @default.
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• W3092691657 cites W2149784435 @default.
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• W3092691657 cites W2335793642 @default.
• W3092691657 cites W2366722352 @default.
• W3092691657 cites W2416243378 @default.
• W3092691657 cites W2567089548 @default.
• W3092691657 cites W2783761104 @default.
• W3092691657 cites W2803423201 @default.
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• W3092691657 cites W2913259928 @default.
• W3092691657 cites W2913807423 @default.
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• W3092691657 doi "https://doi.org/10.1016/j.toxrep.2020.10.011" @default.
• W3092691657 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7600389" @default.
• W3092691657 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33163366" @default.
• W3092691657 hasPublicationYear "2020" @default.
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