FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3092711976> ?p ?o ?g. }

• W3092711976 abstract "Despite the wide use of statins and other LDL-cholesterol (LDL-C)-lowering therapies, atherosclerotic cardiovascular disease remains an important cause of mortality and morbidity. Here, we discuss efficacy, side effects and convenience of current and future therapies inhibiting proprotein convertase subtilisin/kexin type 9 (PCSK9).Clinical trials with mAbs administered every 2-4 weeks and small interfering RNAs given two to four times per year have consistently demonstrated substantial LDL-C-lowering (40-60%) and improved outcome when added to existing lipid-lowering therapies. Pleiotropic effects of PCSK9 inhibition are somewhat different from those observed with statin treatment as evidenced by reduced levels of triglycerides and lipoprotein(a) with no apparent effect on inflammatory markers in patients treated with PCSK9 inhibitors. Treatment with mAb and small interfering RNA are associated with a high-cost, however, small molecules and vaccines may improve cost and convenience if development of these are successful.PCSK9 inhibitors are currently considered to be an add-on therapy and whether these drugs will be used as stand-alone and/or as a first choice is dependent on clinical readouts from ongoing and future trials, real-world evidence, convenience and treatment costs." @default.
• W3092711976 created "2020-10-22" @default.
• W3092711976 creator A5004099465 @default.
• W3092711976 creator A5076018778 @default.
• W3092711976 creator A5088177635 @default.
• W3092711976 date "2020-10-14" @default.
• W3092711976 modified "2023-10-18" @default.
• W3092711976 title "Proprotein convertase subtilisin/kexin type 9 inhibition as the next statin?" @default.
• W3092711976 cites W121888607 @default.
• W3092711976 cites W1583447426 @default.
• W3092711976 cites W2008960002 @default.
• W3092711976 cites W2036304437 @default.
• W3092711976 cites W2040612932 @default.
• W3092711976 cites W2067539811 @default.
• W3092711976 cites W2097510503 @default.
• W3092711976 cites W2106285889 @default.
• W3092711976 cites W2137983259 @default.
• W3092711976 cites W2159925269 @default.
• W3092711976 cites W2286999219 @default.
• W3092711976 cites W2314193179 @default.
• W3092711976 cites W2595169180 @default.
• W3092711976 cites W2596179513 @default.
• W3092711976 cites W2609543937 @default.
• W3092711976 cites W2654759377 @default.
• W3092711976 cites W2754562397 @default.
• W3092711976 cites W2767878281 @default.
• W3092711976 cites W2791615591 @default.
• W3092711976 cites W2794320485 @default.
• W3092711976 cites W2898502019 @default.
• W3092711976 cites W2899997727 @default.
• W3092711976 cites W2900103074 @default.
• W3092711976 cites W2912523391 @default.
• W3092711976 cites W2922307938 @default.
• W3092711976 cites W2925864422 @default.
• W3092711976 cites W2937406445 @default.
• W3092711976 cites W2941139188 @default.
• W3092711976 cites W2960913366 @default.
• W3092711976 cites W2961389662 @default.
• W3092711976 cites W2966503756 @default.
• W3092711976 cites W2967371500 @default.
• W3092711976 cites W2973253443 @default.
• W3092711976 cites W2993037236 @default.
• W3092711976 cites W2996070127 @default.
• W3092711976 cites W3000263047 @default.
• W3092711976 cites W3000712048 @default.
• W3092711976 cites W3011005820 @default.
• W3092711976 cites W3012265841 @default.
• W3092711976 doi "https://doi.org/10.1097/mol.0000000000000718" @default.
• W3092711976 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33060383" @default.
• W3092711976 hasPublicationYear "2020" @default.
• W3092711976 type Work @default.
• W3092711976 sameAs 3092711976 @default.
• W3092711976 citedByCount "5" @default.
• W3092711976 countsByYear W30927119762021 @default.
• W3092711976 countsByYear W30927119762022 @default.
• W3092711976 countsByYear W30927119762023 @default.
• W3092711976 crossrefType "journal-article" @default.
• W3092711976 hasAuthorship W3092711976A5004099465 @default.
• W3092711976 hasAuthorship W3092711976A5076018778 @default.
• W3092711976 hasAuthorship W3092711976A5088177635 @default.
• W3092711976 hasConcept C126322002 @default.
• W3092711976 hasConcept C181199279 @default.
• W3092711976 hasConcept C185592680 @default.
• W3092711976 hasConcept C2776839432 @default.
• W3092711976 hasConcept C2778163477 @default.
• W3092711976 hasConcept C2778824825 @default.
• W3092711976 hasConcept C2778849439 @default.
• W3092711976 hasConcept C2779134260 @default.
• W3092711976 hasConcept C2779811187 @default.
• W3092711976 hasConcept C2780072125 @default.
• W3092711976 hasConcept C2780948078 @default.
• W3092711976 hasConcept C43554185 @default.
• W3092711976 hasConcept C535046627 @default.
• W3092711976 hasConcept C55493867 @default.
• W3092711976 hasConcept C60644358 @default.
• W3092711976 hasConcept C71924100 @default.
• W3092711976 hasConcept C86803240 @default.
• W3092711976 hasConcept C98274493 @default.
• W3092711976 hasConceptScore W3092711976C126322002 @default.
• W3092711976 hasConceptScore W3092711976C181199279 @default.
• W3092711976 hasConceptScore W3092711976C185592680 @default.
• W3092711976 hasConceptScore W3092711976C2776839432 @default.
• W3092711976 hasConceptScore W3092711976C2778163477 @default.
• W3092711976 hasConceptScore W3092711976C2778824825 @default.
• W3092711976 hasConceptScore W3092711976C2778849439 @default.
• W3092711976 hasConceptScore W3092711976C2779134260 @default.
• W3092711976 hasConceptScore W3092711976C2779811187 @default.
• W3092711976 hasConceptScore W3092711976C2780072125 @default.
• W3092711976 hasConceptScore W3092711976C2780948078 @default.
• W3092711976 hasConceptScore W3092711976C43554185 @default.
• W3092711976 hasConceptScore W3092711976C535046627 @default.
• W3092711976 hasConceptScore W3092711976C55493867 @default.
• W3092711976 hasConceptScore W3092711976C60644358 @default.
• W3092711976 hasConceptScore W3092711976C71924100 @default.
• W3092711976 hasConceptScore W3092711976C86803240 @default.
• W3092711976 hasConceptScore W3092711976C98274493 @default.
• W3092711976 hasLocation W30927119761 @default.
• W3092711976 hasLocation W30927119762 @default.
• W3092711976 hasOpenAccess W3092711976 @default.
• W3092711976 hasPrimaryLocation W30927119761 @default.

• next