FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3092743239> ?p ?o ?g. }

• W3092743239 endingPage "105657" @default.
• W3092743239 startingPage "105657" @default.
• W3092743239 abstract "Hydrogen peroxide (H2O2) appears to be ubiquitous in natural water. Higher level of H2O2 can cause physiological stress, immunosuppression and even death in aquatic animals, but the physiological and molecular mechanisms of H2O2 toxicity are not well studied. Thus, the aim of the present study was to exposure potential toxic mechanisms of H2O2 via assessing the effects on redox state, apoptosis and endoplasmic reticulum (ER) stress in common carp. The fish were subjected to four concentrations of H2O2 (0, 0.25, 0.5 and 1 mM) for 14 days. And then, the tissues including blood, liver, muscle, gills, intestines, heart, kidney and spleen were collected to measure biochemical parameter and gene expression. The results showed that H2O2 exposure suppressed the majority antioxidative parameters in serum, liver, muscle and intestines, but enhanced T-SOD, CAT and T-AOC levels in gills. In all tested tissues, the MDA content was significantly promoted by H2O2 exposure. The oxidative stress-related genes including nrf2, gstα, sod, cat and/or gpx1 were upregulated in liver, gills, muscle, intestines, and/or kidney, but downregulated in heart after H2O2 exposure. Moreover, the ho-1 mRNA level was inhibited by H2O2 exposure in all tissues except intestines and spleen. After 14 days of exposure, H2O2 induced ER stress and initiated IRE1 and PERK pathways, which activated downstream genes, including chop, grp78 and/or xbp1s, to regulate UPR in liver, gills, muscle and/or heart. Meanwhile, H2O2 exposure activated MAPK pathway to regulate mitochondria-related genes including bcl-2, bax and cytc, which further triggered cas-8, cas-9 and cas-3, and accelerated apoptosis in liver, gills, muscle and heart. Importantly, in different tissues, the genes associated with oxidative stress, ER stress and apoptosis showed a different influence, and more significant influence was observed in the muscle, gills and liver. Overall results suggested that long-term H2O2 exposure induced oxidative stress, ER stress and apoptosis in the majority of tested tissues of common carp. The Nrf2, IRE1, PERK and MAPK pathways played important roles in H2O2-induced toxicity in fish. These data enriched the toxicity mechanism of H2O2 in fish, which might contribute to the risk assessment of H2O2 in aquatic environment." @default.
• W3092743239 created "2020-10-22" @default.
• W3092743239 creator A5000838832 @default.
• W3092743239 creator A5030197447 @default.
• W3092743239 creator A5031782229 @default.
• W3092743239 creator A5033161116 @default.
• W3092743239 creator A5035530788 @default.
• W3092743239 creator A5041055678 @default.
• W3092743239 creator A5085140875 @default.
• W3092743239 date "2020-12-01" @default.
• W3092743239 modified "2023-10-14" @default.
• W3092743239 title "Chronic exposure of hydrogen peroxide alters redox state, apoptosis and endoplasmic reticulum stress in common carp (Cyprinus carpio)" @default.
• W3092743239 cites W1591900372 @default.
• W3092743239 cites W1747679942 @default.
• W3092743239 cites W1825986551 @default.
• W3092743239 cites W1967789415 @default.
• W3092743239 cites W1969739096 @default.
• W3092743239 cites W1976894040 @default.
• W3092743239 cites W1977623944 @default.
• W3092743239 cites W1980791961 @default.
• W3092743239 cites W1981883990 @default.
• W3092743239 cites W1983310681 @default.
• W3092743239 cites W1986891598 @default.
• W3092743239 cites W1990840402 @default.
• W3092743239 cites W1990953997 @default.
• W3092743239 cites W1991172335 @default.
• W3092743239 cites W1991865867 @default.
• W3092743239 cites W1992361007 @default.
• W3092743239 cites W1992390260 @default.
• W3092743239 cites W1997270203 @default.
• W3092743239 cites W1999682415 @default.
• W3092743239 cites W2002769318 @default.
• W3092743239 cites W2006198113 @default.
• W3092743239 cites W2007026045 @default.
• W3092743239 cites W2008108411 @default.
• W3092743239 cites W2008701132 @default.
• W3092743239 cites W2012323237 @default.
• W3092743239 cites W2015392958 @default.
• W3092743239 cites W2018558490 @default.
• W3092743239 cites W2023374241 @default.
• W3092743239 cites W2024742070 @default.
• W3092743239 cites W2027328852 @default.
• W3092743239 cites W2028006665 @default.
• W3092743239 cites W2030210958 @default.
• W3092743239 cites W2034999802 @default.
• W3092743239 cites W2036457406 @default.
• W3092743239 cites W2045424481 @default.
• W3092743239 cites W2058867779 @default.
• W3092743239 cites W2065490886 @default.
• W3092743239 cites W2066540709 @default.
• W3092743239 cites W2066654943 @default.
• W3092743239 cites W2081690197 @default.
• W3092743239 cites W2083883672 @default.
• W3092743239 cites W2085805621 @default.
• W3092743239 cites W2086991770 @default.
• W3092743239 cites W2087427054 @default.
• W3092743239 cites W2090745313 @default.
• W3092743239 cites W2091373950 @default.
• W3092743239 cites W2094394730 @default.
• W3092743239 cites W2094939646 @default.
• W3092743239 cites W2107277218 @default.
• W3092743239 cites W2112286580 @default.
• W3092743239 cites W2117800935 @default.
• W3092743239 cites W2118898883 @default.
• W3092743239 cites W2124161324 @default.
• W3092743239 cites W2125289626 @default.
• W3092743239 cites W2128473487 @default.
• W3092743239 cites W2129757613 @default.
• W3092743239 cites W2137662702 @default.
• W3092743239 cites W2144065739 @default.
• W3092743239 cites W2148125367 @default.
• W3092743239 cites W2162076197 @default.
• W3092743239 cites W2162853795 @default.
• W3092743239 cites W2163187840 @default.
• W3092743239 cites W2263498456 @default.
• W3092743239 cites W2346162958 @default.
• W3092743239 cites W2496389095 @default.
• W3092743239 cites W2519786994 @default.
• W3092743239 cites W2527917082 @default.
• W3092743239 cites W2551446705 @default.
• W3092743239 cites W2568510753 @default.
• W3092743239 cites W2570093594 @default.
• W3092743239 cites W2577905297 @default.
• W3092743239 cites W2587383465 @default.
• W3092743239 cites W2659467946 @default.
• W3092743239 cites W2757623693 @default.
• W3092743239 cites W2766138174 @default.
• W3092743239 cites W2776322228 @default.
• W3092743239 cites W2789237694 @default.
• W3092743239 cites W2790628760 @default.
• W3092743239 cites W2791513217 @default.
• W3092743239 cites W2801790428 @default.
• W3092743239 cites W2801956832 @default.
• W3092743239 cites W2803716014 @default.
• W3092743239 cites W2810166530 @default.
• W3092743239 cites W2844839615 @default.
• W3092743239 cites W2877283753 @default.
• W3092743239 cites W2883993574 @default.

• next