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- W3092763346 abstract "Abstract Motor neuron diseases (MNDs) are etiologically and biologically heterogeneous diseases. The pathobiology of motor neuron degeneration is still largely unknown, and no effective therapy is available. Heterogeneity and lack of specific disease biomarkers have been appointed as leading reasons for past clinical trial failure, and biomarker discovery is pivotal in today’s MND research agenda. In the last decade, neurofilaments (NFs) have emerged as promising biomarkers for the clinical assessment of neurodegeneration. NFs are scaffolding proteins with predominant structural functions contributing to the axonal cytoskeleton of myelinated axons. NFs are released in CSF and peripheral blood as a consequence of axonal degeneration, irrespective of the primary causal event. Due to the current availability of highly-sensitive automated technologies capable of precisely quantify proteins in biofluids in the femtomolar range, it is now possible to reliably measure NFs not only in CSF but also in blood. In this review, we will discuss how NFs are impacting research and clinical management in ALS and other MNDs. Besides contributing to the diagnosis at early stages by differentiating between MNDs with different clinical evolution and severity, NFs may provide a useful tool for the early enrolment of patients in clinical trials. Due to their stability across the disease, NFs convey prognostic information and, on a larger scale, help to stratify patients in homogenous groups. Shortcomings of NFs assessment in biofluids will also be discussed according to the available literature in the attempt to predict the most appropriate use of the biomarker in the MND clinic." @default.
- W3092763346 created "2020-10-22" @default.
- W3092763346 creator A5017248165 @default.
- W3092763346 creator A5023875722 @default.
- W3092763346 creator A5042225964 @default.
- W3092763346 creator A5053912816 @default.
- W3092763346 creator A5060876047 @default.
- W3092763346 creator A5067433680 @default.
- W3092763346 creator A5068622580 @default.
- W3092763346 date "2020-10-15" @default.
- W3092763346 modified "2023-10-17" @default.
- W3092763346 title "Neurofilaments in motor neuron disorders: towards promising diagnostic and prognostic biomarkers" @default.
- W3092763346 cites W1480524493 @default.
- W3092763346 cites W1491453222 @default.
- W3092763346 cites W1576514072 @default.
- W3092763346 cites W1907551740 @default.
- W3092763346 cites W1927582128 @default.
- W3092763346 cites W1951784167 @default.
- W3092763346 cites W1963794711 @default.
- W3092763346 cites W1965434700 @default.
- W3092763346 cites W1981295136 @default.
- W3092763346 cites W1981929653 @default.
- W3092763346 cites W1986234504 @default.
- W3092763346 cites W1987173022 @default.
- W3092763346 cites W1992768136 @default.
- W3092763346 cites W1996340200 @default.
- W3092763346 cites W1996973828 @default.
- W3092763346 cites W2002021660 @default.
- W3092763346 cites W2006817097 @default.
- W3092763346 cites W2010725749 @default.
- W3092763346 cites W2018726628 @default.
- W3092763346 cites W2025504745 @default.
- W3092763346 cites W2026818720 @default.
- W3092763346 cites W2026863482 @default.
- W3092763346 cites W2032162800 @default.
- W3092763346 cites W2052111329 @default.
- W3092763346 cites W2053011315 @default.
- W3092763346 cites W2060876918 @default.
- W3092763346 cites W2062810043 @default.
- W3092763346 cites W2071434138 @default.
- W3092763346 cites W2089034809 @default.
- W3092763346 cites W2090078115 @default.
- W3092763346 cites W2090203936 @default.
- W3092763346 cites W2095685454 @default.
- W3092763346 cites W2099058096 @default.
- W3092763346 cites W2108296389 @default.
- W3092763346 cites W2110904537 @default.
- W3092763346 cites W2120338495 @default.
- W3092763346 cites W2121554950 @default.
- W3092763346 cites W2136911505 @default.
- W3092763346 cites W2157203036 @default.
- W3092763346 cites W2158562257 @default.
- W3092763346 cites W2167912995 @default.
- W3092763346 cites W2306559597 @default.
- W3092763346 cites W2322683956 @default.
- W3092763346 cites W2342233016 @default.
- W3092763346 cites W2415678243 @default.
- W3092763346 cites W2510806376 @default.
- W3092763346 cites W2530101855 @default.
- W3092763346 cites W2547494415 @default.
- W3092763346 cites W2548027654 @default.
- W3092763346 cites W2556818673 @default.
- W3092763346 cites W2587612122 @default.
- W3092763346 cites W2590887570 @default.
- W3092763346 cites W2592442004 @default.
- W3092763346 cites W2594565722 @default.
- W3092763346 cites W2604210857 @default.
- W3092763346 cites W2605303518 @default.
- W3092763346 cites W2612214304 @default.
- W3092763346 cites W2675950738 @default.
- W3092763346 cites W2766864364 @default.
- W3092763346 cites W2771354240 @default.
- W3092763346 cites W2783558163 @default.
- W3092763346 cites W2784297687 @default.
- W3092763346 cites W2797874870 @default.
- W3092763346 cites W2801763277 @default.
- W3092763346 cites W2804581020 @default.
- W3092763346 cites W2807994038 @default.
- W3092763346 cites W2807994366 @default.
- W3092763346 cites W2808399212 @default.
- W3092763346 cites W2884390718 @default.
- W3092763346 cites W2884621959 @default.
- W3092763346 cites W2888963729 @default.
- W3092763346 cites W2889223700 @default.
- W3092763346 cites W2890542093 @default.
- W3092763346 cites W2892527289 @default.
- W3092763346 cites W2897165775 @default.
- W3092763346 cites W2898256188 @default.
- W3092763346 cites W2899128456 @default.
- W3092763346 cites W2901521475 @default.
- W3092763346 cites W2902468475 @default.
- W3092763346 cites W2910657247 @default.
- W3092763346 cites W2915286327 @default.
- W3092763346 cites W2921595875 @default.
- W3092763346 cites W2923401400 @default.
- W3092763346 cites W2933081937 @default.
- W3092763346 cites W2939958603 @default.
- W3092763346 cites W2943910290 @default.
- W3092763346 cites W2945865866 @default.
- W3092763346 cites W2947442321 @default.