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- W3092797853 abstract "Abstract Background: Scientist have been facing numerous challenges in the development of an effective therapeutic strategy for the treatment of COVID-19 pneumonia. Several studies have suggested that improving patient immunity and reducing lung injury induced by COVID -19 could be effective in treating the patients with COVID-19. Methods: A pilot trial of nebulization therapy for COVID-19 pneumonia with exosomes of MSCs was performed on seven patients with COVID-19 infected pneumonia. Exosomes were collected and purified from secretion of MSCs using multiple ultrafiltration. All patients was treated with nebulization of MSC-derived exosomes. The primary safety and efficacy outcome were observed. Results: Our clinical study demonstrated that nebulization mesenchymal stem cell (MSCs)-derived exosomes is a novel method that could be utilized in the treatment of COVID-19 pneumonia. Nebulization of MSC-derived exosomes did not induce acute allergic and secondary allergic reactions. It could promote the absorption of pulmonary lesions, and reduce the time of hospitalization for minor cases of COVID-19 pneumonia. Conclusions: Nebulization of MSC-derived exosomes is a safe, effective, and simple method. Nebulization of MSC-derived exosomes from the beginning of the treatment could be more beneficial to the patients. Trial registration : Chinese Clinical Trial Registry, ChiCTR2000030261. Registered on 26 February 2020." @default.
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- W3092797853 date "2020-11-02" @default.
- W3092797853 modified "2023-09-26" @default.
- W3092797853 title "Nebulization Therapy for COVID-19 Pneumonia with Embryonic Mesenchymal Stem Cells-derived Exosomes" @default.
- W3092797853 doi "https://doi.org/10.21203/rs.3.rs-99753/v1" @default.
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