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• W3092801551 abstract "Total progressive motile sperm count (TPMC) is commonly used in evaluating the male partner in subfertile couples. A TPMC value of >20 million is generally considered normal. We hypothesized that higher TPMC values are associated with more efficient conception rates in subfertile couples. We aimed to find a threshold that is best associated with time to spontaneous conception. Retrospective cohort study. We used longitudinal data from a cohort of subfertile men seen at a single institution from 2002-2017. Demographics and baseline semen parameters, as well as number of children before the first semen analysis (SA) were collected. Couples who used ART or IUI were excluded. Couples were categorized into two cohorts: 1) Male or unexplained infertility: this category included men with a known male factor diagnosis or absence of female factor infertility or 2) those with female factor infertility. Conception data within 5 years of the first SA were collected. We used a log-rank test to select TPMC thresholds associated with earlier time to conception in either cohorts. Cox proportional hazard models were used to compare time to conception across TPMC categories, adjusting for age, BMI, number of previous children and income. A total of 5126 men with mean age of 32.5±6.5 years were included. Median TPMC was 113.1 M. Overall, 59% of couples were able to conceive spontaneously within 5 years of the male partner’s first SA (median time: 27 months, 95% CI: 26–30). Overall, a TPMC threshold of 50 million provided the highest log-rank statistic in predicting earlier time to conception. Those with TPMC>=50 million had 60% increased chances of achieving natural conception within 5 years (HR: 1.60, 95% CI:1.45–1.76, P<0.001) In couples with male factor or unexplained infertility the best TPMC threshold was 70 million and in those with documented female factor infertility the best threshold was 60 million. A TPMC threshold of 50 million provides a better prediction for time to spontaneous conception in a large cohort of subfertile men. The optimal threshold can be slightly different depending on the infertility cause at couples’ level, however, the clinical significance of these small variations remains unknown." @default.
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• W3092801551 date "2020-09-01" @default.
• W3092801551 modified "2023-10-16" @default.
• W3092801551 title "WHAT IS THE OPTIMAL THRESHOLD FOR TOTAL PROGRESSIVE MOTILE SPERM COUNT IN PREDICTING SPONTANEOUS CONCEPTION IN SUBFERTILE COUPLES?" @default.
• W3092801551 doi "https://doi.org/10.1016/j.fertnstert.2020.08.182" @default.
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