Matches in SemOpenAlex for { <https://semopenalex.org/work/W3092826136> ?p ?o ?g. }
- W3092826136 endingPage "7554" @default.
- W3092826136 startingPage "7554" @default.
- W3092826136 abstract "Stroke is a major challenge in modern medicine and understanding the role of the neuronal extracellular matrix (NECM) in its pathophysiology is fundamental for promoting brain repair. Currently, stroke research is focused on the neurovascular unit (NVU). Impairment of the NVU leads to neuronal loss through post-ischemic and reperfusion injuries, as well as coagulatory and inflammatory processes. The ictal core is produced in a few minutes by the high metabolic demand of the central nervous system. Uncontrolled or prolonged inflammatory response is characterized by leukocyte infiltration of the injured site that is limited by astroglial reaction. The metabolic failure reshapes the NECM through matrix metalloproteinases (MMPs) and novel deposition of structural proteins continues within months of the acute event. These maladaptive reparative processes are responsible for the neurological clinical phenotype. In this review, we aim to provide a systems biology approach to stroke pathophysiology, relating the injury to the NVU with the pervasive metabolic failure, inflammatory response and modifications of the NECM. The available data will be used to build a protein–protein interaction (PPI) map starting with 38 proteins involved in stroke pathophysiology, taking into account the timeline of damage and the co-expression scores of their RNA patterns The application of the proposed network could lead to a more accurate design of translational experiments aiming at improving both the therapy and the rehabilitation processes." @default.
- W3092826136 created "2020-10-22" @default.
- W3092826136 creator A5005215737 @default.
- W3092826136 creator A5005988178 @default.
- W3092826136 creator A5011688993 @default.
- W3092826136 creator A5015377343 @default.
- W3092826136 creator A5069308382 @default.
- W3092826136 creator A5073702139 @default.
- W3092826136 date "2020-10-13" @default.
- W3092826136 modified "2023-09-27" @default.
- W3092826136 title "Roadmap for Stroke: Challenging the Role of the Neuronal Extracellular Matrix" @default.
- W3092826136 cites W1487068141 @default.
- W3092826136 cites W1520421559 @default.
- W3092826136 cites W1608593799 @default.
- W3092826136 cites W1725925038 @default.
- W3092826136 cites W1834139870 @default.
- W3092826136 cites W1961885071 @default.
- W3092826136 cites W1966214665 @default.
- W3092826136 cites W1969909530 @default.
- W3092826136 cites W1972368241 @default.
- W3092826136 cites W1973077882 @default.
- W3092826136 cites W1976152949 @default.
- W3092826136 cites W1987751736 @default.
- W3092826136 cites W1989248729 @default.
- W3092826136 cites W1992218027 @default.
- W3092826136 cites W1992981081 @default.
- W3092826136 cites W1997912239 @default.
- W3092826136 cites W1999495459 @default.
- W3092826136 cites W2005378461 @default.
- W3092826136 cites W2007898062 @default.
- W3092826136 cites W2012162957 @default.
- W3092826136 cites W2016107310 @default.
- W3092826136 cites W2018130919 @default.
- W3092826136 cites W2021328900 @default.
- W3092826136 cites W2021547629 @default.
- W3092826136 cites W2023236768 @default.
- W3092826136 cites W2023250693 @default.
- W3092826136 cites W2023582307 @default.
- W3092826136 cites W2025369883 @default.
- W3092826136 cites W2025899545 @default.
- W3092826136 cites W2028704942 @default.
- W3092826136 cites W2029940067 @default.
- W3092826136 cites W2030174218 @default.
- W3092826136 cites W2035268168 @default.
- W3092826136 cites W2042089035 @default.
- W3092826136 cites W2045118987 @default.
- W3092826136 cites W2046803215 @default.
- W3092826136 cites W2048857313 @default.
- W3092826136 cites W2049220062 @default.
- W3092826136 cites W2054626405 @default.
- W3092826136 cites W2056081556 @default.
- W3092826136 cites W2061250188 @default.
- W3092826136 cites W2072001685 @default.
- W3092826136 cites W2073730022 @default.
- W3092826136 cites W2081523250 @default.
- W3092826136 cites W2082870917 @default.
- W3092826136 cites W2084049757 @default.
- W3092826136 cites W2084379750 @default.
- W3092826136 cites W2089397496 @default.
- W3092826136 cites W2089725161 @default.
- W3092826136 cites W2090419287 @default.
- W3092826136 cites W2094287689 @default.
- W3092826136 cites W2101430926 @default.
- W3092826136 cites W2102935355 @default.
- W3092826136 cites W2103420764 @default.
- W3092826136 cites W2106361045 @default.
- W3092826136 cites W2121218248 @default.
- W3092826136 cites W2122081605 @default.
- W3092826136 cites W2126182481 @default.
- W3092826136 cites W2129122439 @default.
- W3092826136 cites W2133514192 @default.
- W3092826136 cites W2133956375 @default.
- W3092826136 cites W2134512768 @default.
- W3092826136 cites W2135376726 @default.
- W3092826136 cites W2140982760 @default.
- W3092826136 cites W2141683458 @default.
- W3092826136 cites W2144890529 @default.
- W3092826136 cites W2145053539 @default.
- W3092826136 cites W2148320340 @default.
- W3092826136 cites W2149970650 @default.
- W3092826136 cites W2151286409 @default.
- W3092826136 cites W2155477484 @default.
- W3092826136 cites W2156234950 @default.
- W3092826136 cites W2165380579 @default.
- W3092826136 cites W2174685926 @default.
- W3092826136 cites W2175733304 @default.
- W3092826136 cites W2217490962 @default.
- W3092826136 cites W2291386403 @default.
- W3092826136 cites W2322217390 @default.
- W3092826136 cites W2335534790 @default.
- W3092826136 cites W2488621239 @default.
- W3092826136 cites W2559837976 @default.
- W3092826136 cites W2584319950 @default.
- W3092826136 cites W2593719298 @default.
- W3092826136 cites W2597229620 @default.
- W3092826136 cites W2604098146 @default.
- W3092826136 cites W2608642538 @default.
- W3092826136 cites W2611340079 @default.