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• W3092853513 abstract "Vitrified, or “frozen”, donor eggs (VDE) can either be fertilized and cultured for fresh transfer (group 1), or fertilized and cryopreserved for transfer in a “frozen embryo transfer” cycle (FET, group 2). This study compared implantation rates between the two groups. A retrospective cohort study analyzing 800 frozen donor egg cycles from a commercial egg bank. Cycles were limited to single embryo transfers (ET) without preimplantation genetic testing (PGT). The data was analyzed using the Chi-squared test for categorical variables and the Wilcoxon-Mann-Whitney test for non-parametric continuous variables. P-values <0.05 were regarded as statistically significant. SAS version 9.4 was used for the analysis. 600 cycles met the inclusion criteria (200 were excluded due to PGT or multiple embryo transfers). There were 409 cycles in group 1 and 191 cycles in group 2. Implantation rate was not significantly different between the two groups (38.63% vs 32.46% p=0.14). Mean embryo age was higher in group 2 (5.1 vs 5.4 days, p< 0.01). Contrary to experiences with slow-cooling, a growing body of evidence shows vitrification to have no negative effect on embryo potential, even when subject to multiple vitrify/thaw cycles. To date, however, no investigation has looked at the possible compounding effect of vitrification when applied at two distinct stages: oocyte and embryo. In this study we compared implantation of VDE cycles transferred in fresh versus FET cycles to determine if such an effect exists. Although embryos used in FET cycles were statistically older, as would be expected due to extended culture, no difference was detected between the groups in terms of implantation. Unexpectedly, the data demonstrated a trend toward lower implantation in the FET group, which stands contrary to trends observed with fresh oocyte/FET cycles. While not significant at this power, a larger study should be undertaken to determine the validity of this effect and whether it represents a clinical concern when planning patient cycles." @default.
• W3092853513 created "2020-10-22" @default.
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• W3092853513 date "2020-09-01" @default.
• W3092853513 modified "2023-09-28" @default.
• W3092853513 title "DOES CRYOPRESERVATION AFFECT THE IMPLANTATION POTENTIAL OF BLASTOCYSTS DERIVED FROM VITRIFIED/WARMED OOCYTES?" @default.
• W3092853513 doi "https://doi.org/10.1016/j.fertnstert.2020.08.806" @default.
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