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- W3092884609 endingPage "101763" @default.
- W3092884609 startingPage "101763" @default.
- W3092884609 abstract "Nuclear factor, erythroid 2 like 2 (Nrf2), is an oxidative stress induced transcription factor that regulates cytoprotective gene expression. Thus, Nrf2 is essential for cellular redox homeostasis. Loss or dysregulation of Nrf2 expression has been implicated in the pathogenesis of degenerative diseases, including diseases of the cornea. One of the most common diseases of the cornea in which Nrf2 is implicated is Fuchs' endothelial cornea dystrophy (FECD). FECD is the leading indication for corneal transplantation; and is associated with a loss of corneal endothelial cell (CEC) function. In this review, we propose that Nrf2 is an essential regulator of CEC function. Furthermore, we demonstrate that deficiency of Nrf2 function is a hallmark of FECD. In addition, we advocate that pharmacological targeting of Nrf2 as a possible therapy for FECD." @default.
- W3092884609 created "2020-10-22" @default.
- W3092884609 creator A5019289283 @default.
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- W3092884609 creator A5050145910 @default.
- W3092884609 creator A5068363222 @default.
- W3092884609 creator A5087723724 @default.
- W3092884609 date "2020-10-01" @default.
- W3092884609 modified "2023-10-14" @default.
- W3092884609 title "Nrf2: A unifying transcription factor in the pathogenesis of Fuchs’ endothelial corneal dystrophy" @default.
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