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• W3092886450 endingPage "153340" @default.
• W3092886450 startingPage "153340" @default.
• W3092886450 abstract "Oleanolic acid (OA) is an active compound found in a variety of medicinal herbs and plants. Though OA has been widely attributed with a variety of biological activities, studies focused on its anti-allergic inflammation properties are insufficient. Given the rapid increase in allergic diseases and the lack of fundamental treatment options, this study aimed to find a safe and effective therapy for allergic disorders. We evaluated the inhibitory effect of OA on allergic inflammatory response and the possible mechanisms underlying the effect using phorbol-12-myristate 13-acetate plus calcium ionophore A23187 (PMACI)-stimulated human mast cell (HMC)-1, and a mouse model of compound 48/80-induced anaphylactic shock. OA suppressed pro-inflammatory cytokine expressions in PMACI-induced HMC-1 cells by inhibiting activation of the Akt, p38 mitogen-activated protein kinase (MAPK), nuclear factor-κB (NF-κB), and signal transducer and activator of transcription (STAT) 1 signaling pathways. Moreover, OA showed a protective effect against compound 48/80-induced anaphylactic shock through inhibition of histamine release and immunoglobulin E level via regulation of NF-κB and STAT1 activation. The results showed that OA suppressed mast cell-mediated allergic response by transcriptional regulation. We suggest that OA has potential effect against allergic inflammatory disorders, including anaphylaxis, and might be a useful therapeutic agent for allergic disease." @default.
• W3092886450 created "2020-10-22" @default.
• W3092886450 creator A5010258407 @default.
• W3092886450 creator A5015565837 @default.
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• W3092886450 date "2021-01-01" @default.
• W3092886450 modified "2023-09-26" @default.
• W3092886450 title "Oleanolic acid protects against mast cell-mediated allergic responses by suppressing Akt/NF-κB and STAT1 activation" @default.
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• W3092886450 doi "https://doi.org/10.1016/j.phymed.2020.153340" @default.
• W3092886450 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33130471" @default.
• W3092886450 hasPublicationYear "2021" @default.
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