Matches in SemOpenAlex for { <https://semopenalex.org/work/W3092891036> ?p ?o ?g. }
- W3092891036 endingPage "515" @default.
- W3092891036 startingPage "515" @default.
- W3092891036 abstract "The tropical marine cyanobacterium Moorena bouillonii occupies a large geographic range across the Indian and Western Tropical Pacific Oceans and is a prolific producer of structurally unique and biologically active natural products. An ensemble of computational approaches, including the creation of the ORCA (Objective Relational Comparative Analysis) pipeline for flexible MS1 feature detection and multivariate analyses, were used to analyze various M. bouillonii samples. The observed chemogeographic patterns suggested the production of regionally specific natural products by M. bouillonii. Analyzing the drivers of these chemogeographic patterns allowed for the identification, targeted isolation, and structure elucidation of a regionally specific natural product, doscadenamide A (1). Analyses of MS2 fragmentation patterns further revealed this natural product to be part of an extensive family of herein annotated, proposed natural structural analogs (doscadenamides B-J, 2-10); the ensemble of structures reflect a combinatorial biosynthesis using nonribosomal peptide synthetase (NRPS) and polyketide synthase (PKS) components. Compound 1 displayed synergistic in vitro cancer cell cytotoxicity when administered with lipopolysaccharide (LPS). These discoveries illustrate the utility in leveraging chemogeographic patterns for prioritizing natural product discovery efforts." @default.
- W3092891036 created "2020-10-22" @default.
- W3092891036 creator A5008831408 @default.
- W3092891036 creator A5018785566 @default.
- W3092891036 creator A5038162702 @default.
- W3092891036 creator A5039038654 @default.
- W3092891036 creator A5042012882 @default.
- W3092891036 creator A5043882012 @default.
- W3092891036 creator A5044292766 @default.
- W3092891036 creator A5049804114 @default.
- W3092891036 creator A5057614857 @default.
- W3092891036 creator A5058400625 @default.
- W3092891036 creator A5070485101 @default.
- W3092891036 creator A5071666503 @default.
- W3092891036 creator A5078277601 @default.
- W3092891036 creator A5078651116 @default.
- W3092891036 creator A5085855646 @default.
- W3092891036 date "2020-10-14" @default.
- W3092891036 modified "2023-10-01" @default.
- W3092891036 title "Applying a Chemogeographic Strategy for Natural Product Discovery from the Marine Cyanobacterium Moorena bouillonii" @default.
- W3092891036 cites W1944989862 @default.
- W3092891036 cites W1964350231 @default.
- W3092891036 cites W1971910884 @default.
- W3092891036 cites W1972710456 @default.
- W3092891036 cites W1973179810 @default.
- W3092891036 cites W1973495005 @default.
- W3092891036 cites W1983700582 @default.
- W3092891036 cites W1985145107 @default.
- W3092891036 cites W1987307477 @default.
- W3092891036 cites W1988957091 @default.
- W3092891036 cites W1989299822 @default.
- W3092891036 cites W1990802251 @default.
- W3092891036 cites W1999908729 @default.
- W3092891036 cites W2004836957 @default.
- W3092891036 cites W2011005231 @default.
- W3092891036 cites W2011301426 @default.
- W3092891036 cites W2012418547 @default.
- W3092891036 cites W2014769274 @default.
- W3092891036 cites W2017719613 @default.
- W3092891036 cites W2017839881 @default.
- W3092891036 cites W2024269666 @default.
- W3092891036 cites W2028466883 @default.
- W3092891036 cites W2035599112 @default.
- W3092891036 cites W2037579170 @default.
- W3092891036 cites W2040238921 @default.
- W3092891036 cites W2040378300 @default.
- W3092891036 cites W2041744495 @default.
- W3092891036 cites W2043148739 @default.
- W3092891036 cites W2044262769 @default.
- W3092891036 cites W2050720265 @default.
- W3092891036 cites W2052077744 @default.
- W3092891036 cites W2052141458 @default.
- W3092891036 cites W2052923854 @default.
- W3092891036 cites W2055635723 @default.
- W3092891036 cites W2057308191 @default.
- W3092891036 cites W2061726894 @default.
- W3092891036 cites W2061939373 @default.
- W3092891036 cites W2064455647 @default.
- W3092891036 cites W2065334402 @default.
- W3092891036 cites W2075164036 @default.
- W3092891036 cites W2076335808 @default.
- W3092891036 cites W2081465448 @default.
- W3092891036 cites W2089195340 @default.
- W3092891036 cites W2090984415 @default.
- W3092891036 cites W2091259099 @default.
- W3092891036 cites W2099188233 @default.
- W3092891036 cites W2112592064 @default.
- W3092891036 cites W2129935236 @default.
- W3092891036 cites W2131954086 @default.
- W3092891036 cites W2135773218 @default.
- W3092891036 cites W2142161977 @default.
- W3092891036 cites W2146292423 @default.
- W3092891036 cites W2150998549 @default.
- W3092891036 cites W2159675211 @default.
- W3092891036 cites W2165624973 @default.
- W3092891036 cites W2320738396 @default.
- W3092891036 cites W2324021033 @default.
- W3092891036 cites W2342249984 @default.
- W3092891036 cites W2417825531 @default.
- W3092891036 cites W2472803348 @default.
- W3092891036 cites W2504691963 @default.
- W3092891036 cites W2516388589 @default.
- W3092891036 cites W2520660959 @default.
- W3092891036 cites W2568938691 @default.
- W3092891036 cites W2569565111 @default.
- W3092891036 cites W2593127685 @default.
- W3092891036 cites W2614068580 @default.
- W3092891036 cites W2735808279 @default.
- W3092891036 cites W2744029246 @default.
- W3092891036 cites W2756286844 @default.
- W3092891036 cites W2765379792 @default.
- W3092891036 cites W2767989234 @default.
- W3092891036 cites W2775781666 @default.
- W3092891036 cites W2788653518 @default.
- W3092891036 cites W2799779159 @default.
- W3092891036 cites W2799903534 @default.
- W3092891036 cites W2803664483 @default.
- W3092891036 cites W2804049454 @default.