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- W3092907950 abstract "BACKGROUND:Hypertension is an independent risk factor for cardiovascular disease. Inflammation plays a major role in atherosclerosis. Markers of innate immunity have been shown to predict the development of coronary artery disease. MBL (mannose binding lectin) being a component of innate immunity can be used as a marker of cardiovascular risk in hypertension.AIM AND OBJECTIVES:The study was conducted to1. Evaluate the risk of coronary artery disease in recently diagnosed hypertensive patients by estimating serum mannose binding lectin levels.2. Correlate the serum mannose binding lectin levels with (a) C – ReactiveProtein [CRP ] (b) lipid profile (c) body mass index & (d) renal function test.MATERIALS & METHODS:This cross sectional case control study was conducted among 90 subjects who were divided into three groups as follows:Group A : 30 recently diagnosed hypertensive patients (< 6 months duration).Group B : 30 hypertensive patients who had myocardial infarction recently (< 7 days).Group C : 30 age & sex matched healthy controls.Serum levels of MBL, CRP, total cholesterol, triglycerides, HDL –C, urea, creatinine & uric acid were measured . Collected data were analysed by SPSS – 16 software.RESULTS & CONCLUSION:The serum MBL levels were significantly elevated in hypertensive patients (mean = 823.45) and in hypertensive with myocardial infarction (mean = 1163.39) as compared with control population (mean = 607.15 with p value – 0.001). Positive correlation was observed between higher levels of MBL (> 1000 ng / mL) and CRP.Multivariate logistic regression analysis adjusted for common factor showed the serum MBL level was an independent indicator of cardiovascular disease in hypertension (r = 0.85). From the ROC curve, it has been determined that MBL has good sensitivity (93%) & specificity (96%) with a positive predictive value of 96%.Our findings suggested that MBL is an independent determinant of myocardial infarction in hypertensive patients & the determination of MBL status might be used to identify the patients at increased risk of developing cardiovascular complications." @default.
- W3092907950 created "2020-10-22" @default.
- W3092907950 creator A5028332836 @default.
- W3092907950 date "2019-05-01" @default.
- W3092907950 modified "2023-09-27" @default.
- W3092907950 title "Mannose Binding Lectin as a Diagnostic Marker for Coronary Artery Disease in Hypertensive Patients" @default.
- W3092907950 hasPublicationYear "2019" @default.
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