FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3092908922> ?p ?o ?g. }

• W3092908922 endingPage "e531" @default.
• W3092908922 startingPage "e531" @default.
• W3092908922 abstract "OBJECTIVE: Anti-Mullerian Hormone (AMH) and progesterone are used as biomarkers in assessing fertility and readiness for assisted reproductive procedures, usually measured in blood samples. The objective of this study was to determine if biologically relevant quantities of AMH and progesterone in human hair samples could be assessed. DESIGN: The study design was prospective in nature. A total of (n=152) human female participants between the ages of 18-65 years were included in the study over a period of 10 months (recruitment ongoing). Sample collection was performed in a clinical setting, with blood and hair samples collected from patients. Hair follicles were not required, with a minimum of 100mg of hair cut from the participants. A doctor or a clinical technician measured the antral follicle count (AFC) by ultrasound. Biologically active AMH and progesterone was extracted from hair using a proprietary method. Hormone presence in hair extract was confirmed in a set of samples using Western Blotting. Hormones were measured in plasma and hair extract by ELISA. AMH was detected via ELISA (n=95 in hair, 42 in plasma), and confirmed on a set of samples via western blots on denatured gel with bands at 70kDa. An average level of 9.37 pg/ml (95%CI 6.77-12) was detected in hair and 3.68 ng/ml (95%CI 2.79-4.56) in plasma in age-group <25 yrs. This is in contrast to the age group >39 years, within which a mean of 3.02 pg/ml (95%CI 2.19-3.85) AMH detected in hair and 0.92 ng/ml (95%CI 0.43-1.41) in plasma samples. AMH in hair did not significantly associate with measurements in plasma (effect size 0.19, p value 0.0852). AMH measured in hair correlated with age more strongly than plasma AMH (p-value =1.26 x10-5 (hair), p-value 0.088 (plasma)). AMH levels in hair were also strongly associated with AFC when corrected for hair weight, with an effect size of 3.75 (95% CI: 1.7; 5.8), and P value of 0.0168. Progesterone was measured via ELISA (n=76 in hair, n=91 in plasma) via ELISA. The association between progesterone in plasma and hair was significant (p value of 0.0298, p value of 0.013 when adjusted for hair weight). We found that progesterone and AMH could be detected in human hair samples, and levels of AMH in hair were positively associated with maternal age and antral follicle count. The stronger association of AMH in hair versus plasma with age and AFC suggests that, though AMH is relatively stable during the monthly cycle, acute measurements of AMH may have variability that may make measurement via hair samples of greater utility for assessing reproductive health. Hair is a medium that can accumulate biomarkers over several weeks, while serum is an acute matrix that can represent only current levels. Detection of steroid hormones in hair has been used in neuroendocrinological studies in human and animals. However AMH measurements in hair are not currently employed for clinical purposes. In addition to this benefit, assessing reproductive hormone via a non-invasive method may allow an increased adoption of the use of these hormones in addressing reproductive health." @default.
• W3092908922 created "2020-10-22" @default.
• W3092908922 creator A5005397982 @default.
• W3092908922 creator A5010149485 @default.
• W3092908922 creator A5034237999 @default.
• W3092908922 creator A5045128271 @default.
• W3092908922 creator A5046454858 @default.
• W3092908922 creator A5049881409 @default.
• W3092908922 creator A5055361247 @default.
• W3092908922 creator A5056722815 @default.
• W3092908922 creator A5061815979 @default.
• W3092908922 creator A5066362108 @default.
• W3092908922 creator A5085162958 @default.
• W3092908922 creator A5088663184 @default.
• W3092908922 date "2020-09-01" @default.
• W3092908922 modified "2023-09-27" @default.
• W3092908922 title "QUANTITATIVE DETECTION OF BIOLOGICALLY RELEVANT ANTI-MULLERIAN HORMONE (AMH) AND PROGESTERONE IN HUMAN HAIR SAMPLES" @default.
• W3092908922 doi "https://doi.org/10.1016/j.fertnstert.2020.09.037" @default.
• W3092908922 hasPublicationYear "2020" @default.
• W3092908922 type Work @default.
• W3092908922 sameAs 3092908922 @default.
• W3092908922 citedByCount "0" @default.
• W3092908922 crossrefType "journal-article" @default.
• W3092908922 hasAuthorship W3092908922A5005397982 @default.
• W3092908922 hasAuthorship W3092908922A5010149485 @default.
• W3092908922 hasAuthorship W3092908922A5034237999 @default.
• W3092908922 hasAuthorship W3092908922A5045128271 @default.
• W3092908922 hasAuthorship W3092908922A5046454858 @default.
• W3092908922 hasAuthorship W3092908922A5049881409 @default.
• W3092908922 hasAuthorship W3092908922A5055361247 @default.
• W3092908922 hasAuthorship W3092908922A5056722815 @default.
• W3092908922 hasAuthorship W3092908922A5061815979 @default.
• W3092908922 hasAuthorship W3092908922A5066362108 @default.
• W3092908922 hasAuthorship W3092908922A5085162958 @default.
• W3092908922 hasAuthorship W3092908922A5088663184 @default.
• W3092908922 hasBestOaLocation W30929089221 @default.
• W3092908922 hasConcept C105702510 @default.
• W3092908922 hasConcept C126322002 @default.
• W3092908922 hasConcept C134018914 @default.
• W3092908922 hasConcept C142773365 @default.
• W3092908922 hasConcept C16685009 @default.
• W3092908922 hasConcept C2777216303 @default.
• W3092908922 hasConcept C2777918589 @default.
• W3092908922 hasConcept C2778575703 @default.
• W3092908922 hasConcept C2778780466 @default.
• W3092908922 hasConcept C29456083 @default.
• W3092908922 hasConcept C42407357 @default.
• W3092908922 hasConcept C71315377 @default.
• W3092908922 hasConcept C71924100 @default.
• W3092908922 hasConceptScore W3092908922C105702510 @default.
• W3092908922 hasConceptScore W3092908922C126322002 @default.
• W3092908922 hasConceptScore W3092908922C134018914 @default.
• W3092908922 hasConceptScore W3092908922C142773365 @default.
• W3092908922 hasConceptScore W3092908922C16685009 @default.
• W3092908922 hasConceptScore W3092908922C2777216303 @default.
• W3092908922 hasConceptScore W3092908922C2777918589 @default.
• W3092908922 hasConceptScore W3092908922C2778575703 @default.
• W3092908922 hasConceptScore W3092908922C2778780466 @default.
• W3092908922 hasConceptScore W3092908922C29456083 @default.
• W3092908922 hasConceptScore W3092908922C42407357 @default.
• W3092908922 hasConceptScore W3092908922C71315377 @default.
• W3092908922 hasConceptScore W3092908922C71924100 @default.
• W3092908922 hasIssue "3" @default.
• W3092908922 hasLocation W30929089221 @default.
• W3092908922 hasOpenAccess W3092908922 @default.
• W3092908922 hasPrimaryLocation W30929089221 @default.
• W3092908922 hasRelatedWork W1978930457 @default.
• W3092908922 hasRelatedWork W1984375163 @default.
• W3092908922 hasRelatedWork W1990896009 @default.
• W3092908922 hasRelatedWork W1991634850 @default.
• W3092908922 hasRelatedWork W2017440399 @default.
• W3092908922 hasRelatedWork W2043067495 @default.
• W3092908922 hasRelatedWork W2074431763 @default.
• W3092908922 hasRelatedWork W2133240828 @default.
• W3092908922 hasRelatedWork W2170775580 @default.
• W3092908922 hasRelatedWork W2411910748 @default.
• W3092908922 hasVolume "114" @default.
• W3092908922 isParatext "false" @default.
• W3092908922 isRetracted "false" @default.
• W3092908922 magId "3092908922" @default.
• W3092908922 workType "article" @default.