FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3092920935> ?p ?o ?g. }

• W3092920935 endingPage "e562" @default.
• W3092920935 startingPage "e555" @default.
• W3092920935 abstract "Recently, anti-programmed cell death 1 (PD-1) and anti-programmed cell death ligand 1 (PD-L1) immunotherapies have yielded promising outcomes for patients with advanced non-small cell lung cancer (NSCLC) and led to great interest in applying these agents to treat resectable early-stage NSCLC. The objective of our study was to evaluate PD-L1 protein expression in resectable early-stage NSCLC specimens from a large Northern European cohort, examine the relationship to clinical characteristics, and demonstrate the prognostic role in resected NSCLC.A large cohort of 875 NSCLC tumors consisted of 337 patients from Sweden and 538 patients from Norway was studied. All the patients had undergone pulmonary resection, and most patients had had early-stage NSCLC. PD-L1 protein expression was assessed by immunohistochemistry using the Dako PD-L1 22C3 pharmDx kit. The tumor proportion score for PD-L1 protein expression was compared with comprehensive demographic and clinicopathologic data.The overall prevalence of PD-L1 protein expression in the resectable NSCLC cohort was 9.5% at a tumor proportion score cutoff of ≥ 50%. Stage I NSCLC had lower PD-L1 expression compared with that of the other stages (P = .0012). PD-L1 expression correlated with wild-type EGFR gene expression (P = .0156) and mutated KRAS gene expression (P = .0004). No significant association was found between PD-L1 expression and mortality after multivariable adjustment for clinical characteristics, although the survival curves showed PD-L1 expression significantly correlated with a poor prognosis in the total NSCLC cohort and in the adenocarcinoma subgroup.PD-L1 expression in the present large cohort of resectable NSCLC was relatively low compared with data from clinical trials of advanced NSCLC. PD-L1 expression correlated positively with tumor stage, wild-type EGFR, and KRAS mutation. PD-L1 expression was not found as an independent prognostic factor in the present study. These findings could be important in the future when evaluating the role of anti-PD-1/PD-L1 immunotherapy in the setting of neoadjuvant or adjuvant trials for early-stage resectable NSCLC." @default.
• W3092920935 created "2020-10-22" @default.
• W3092920935 creator A5013014678 @default.
• W3092920935 creator A5018148458 @default.
• W3092920935 creator A5035616597 @default.
• W3092920935 creator A5039002958 @default.
• W3092920935 creator A5050006649 @default.
• W3092920935 creator A5052033876 @default.
• W3092920935 creator A5061791607 @default.
• W3092920935 creator A5071851332 @default.
• W3092920935 creator A5072396841 @default.
• W3092920935 creator A5091504498 @default.
• W3092920935 date "2021-07-01" @default.
• W3092920935 modified "2023-10-18" @default.
• W3092920935 title "Programmed Cell Death Ligand 1 Expression in Resected Non–Small Cell Lung Cancer" @default.
• W3092920935 cites W1586178471 @default.
• W3092920935 cites W1773771017 @default.
• W3092920935 cites W1982488143 @default.
• W3092920935 cites W2033672531 @default.
• W3092920935 cites W2104347254 @default.
• W3092920935 cites W2109485845 @default.
• W3092920935 cites W2124427232 @default.
• W3092920935 cites W2156353875 @default.
• W3092920935 cites W2198093519 @default.
• W3092920935 cites W2210073947 @default.
• W3092920935 cites W2288894747 @default.
• W3092920935 cites W2289295511 @default.
• W3092920935 cites W2293531514 @default.
• W3092920935 cites W2400514548 @default.
• W3092920935 cites W2464190812 @default.
• W3092920935 cites W2527905628 @default.
• W3092920935 cites W2529904548 @default.
• W3092920935 cites W2557730509 @default.
• W3092920935 cites W2560704457 @default.
• W3092920935 cites W2567564314 @default.
• W3092920935 cites W2582960575 @default.
• W3092920935 cites W2587327379 @default.
• W3092920935 cites W2594102731 @default.
• W3092920935 cites W2635951006 @default.
• W3092920935 cites W2683488101 @default.
• W3092920935 cites W2737044461 @default.
• W3092920935 cites W2745149102 @default.
• W3092920935 cites W2753065806 @default.
• W3092920935 cites W2766990765 @default.
• W3092920935 cites W2774645469 @default.
• W3092920935 cites W2790118532 @default.
• W3092920935 cites W2792575938 @default.
• W3092920935 cites W2798160602 @default.
• W3092920935 cites W2804957255 @default.
• W3092920935 cites W2892310829 @default.
• W3092920935 cites W2909800464 @default.
• W3092920935 cites W2922104964 @default.
• W3092920935 cites W2986574661 @default.
• W3092920935 cites W3003015741 @default.
• W3092920935 cites W3005186000 @default.
• W3092920935 doi "https://doi.org/10.1016/j.cllc.2020.09.018" @default.
• W3092920935 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33214079" @default.
• W3092920935 hasPublicationYear "2021" @default.
• W3092920935 type Work @default.
• W3092920935 sameAs 3092920935 @default.
• W3092920935 citedByCount "1" @default.
• W3092920935 countsByYear W30929209352022 @default.
• W3092920935 crossrefType "journal-article" @default.
• W3092920935 hasAuthorship W3092920935A5013014678 @default.
• W3092920935 hasAuthorship W3092920935A5018148458 @default.
• W3092920935 hasAuthorship W3092920935A5035616597 @default.
• W3092920935 hasAuthorship W3092920935A5039002958 @default.
• W3092920935 hasAuthorship W3092920935A5050006649 @default.
• W3092920935 hasAuthorship W3092920935A5052033876 @default.
• W3092920935 hasAuthorship W3092920935A5061791607 @default.
• W3092920935 hasAuthorship W3092920935A5071851332 @default.
• W3092920935 hasAuthorship W3092920935A5072396841 @default.
• W3092920935 hasAuthorship W3092920935A5091504498 @default.
• W3092920935 hasConcept C121608353 @default.
• W3092920935 hasConcept C126322002 @default.
• W3092920935 hasConcept C143998085 @default.
• W3092920935 hasConcept C146357865 @default.
• W3092920935 hasConcept C151730666 @default.
• W3092920935 hasConcept C204232928 @default.
• W3092920935 hasConcept C2776256026 @default.
• W3092920935 hasConcept C2781182431 @default.
• W3092920935 hasConcept C2781187634 @default.
• W3092920935 hasConcept C526805850 @default.
• W3092920935 hasConcept C71924100 @default.
• W3092920935 hasConcept C72563966 @default.
• W3092920935 hasConcept C86803240 @default.
• W3092920935 hasConceptScore W3092920935C121608353 @default.
• W3092920935 hasConceptScore W3092920935C126322002 @default.
• W3092920935 hasConceptScore W3092920935C143998085 @default.
• W3092920935 hasConceptScore W3092920935C146357865 @default.
• W3092920935 hasConceptScore W3092920935C151730666 @default.
• W3092920935 hasConceptScore W3092920935C204232928 @default.
• W3092920935 hasConceptScore W3092920935C2776256026 @default.
• W3092920935 hasConceptScore W3092920935C2781182431 @default.
• W3092920935 hasConceptScore W3092920935C2781187634 @default.
• W3092920935 hasConceptScore W3092920935C526805850 @default.
• W3092920935 hasConceptScore W3092920935C71924100 @default.
• W3092920935 hasConceptScore W3092920935C72563966 @default.

• next