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• W3092935856 abstract "Current data on fertility preservation outcomes in peri-pubertal and adolescent females is limited, with most data originating from oncofertility studies. Few studies explore outcomes in those undergoing fertility preservation for gender dysphoria or other non-oncologic indications. Our objective was to review fertility preservation outcome in patients with gender dysphoria and non-oncologic indications under age 25 at a single academic institution. Specifically, we sought to investigate egg retrieval outcomes as they relate to patient age, gynecologic age (age from menarche to egg retrieval), and AMH. Retrospective case series Patients undergoing oocyte retrieval at an academic institution between age 14 and 25 from 1/2000 to 1/2020 were identified. Included patients were those undergoing egg retrieval for non-medical indication, transgender patients, and egg donors. Patients with ovarian pathology and Sex chromosome disorders including Turners syndrome were excluded. Patients with a cancer diagnosis were excluded given non-traditional stimulation, as well as the potential for cancer to impact ovarian response. Age of menarche and AMH level prior to cycle were identified by chart review. Cycles were evaluated by number of eggs retrieved and number of metaphase II (MII) oocytes. Comparisons were made between cycle outcome and patient age, gynecologic age, and AMH at cycle start. 73 patients were included. There were 10 patients with gender dysphoria, 44 egg donors, and 19 patients undergoing elective egg retrieval. Neither age nor gynecologic age were correlated with number of eggs retrieved (n=88, r=0.16; n=86, r=0.16 respectively) or number of MII eggs (n=88, r=0.05; n=86, r=0.10). AMH value was positively correlated to number of eggs retrieved (n=83, r=0.29) and number of MII eggs (n=83, r=0.26). Overall, in young female patients undergoing egg retrieval for non-oncologic indication, neither age nor gynecologic age were predictive of egg retrieval outcome. As seen in other populations, AMH value may positively correlate with egg retrieval outcome in young females. Further research with a larger study population may elucidate ideal timing for egg retrieval or donation in these peri-pubertal and adolescent females.Tabled 1Age at Retrieval (n)Eggs RetrievedMII Eggs14 (3)14.010.015 (3)18.712.316 (2)29.018.517 (3)25.021.719 (3)21.014.320 (5)15.812.021 (4)16.013.522 (8)24.920.323 (18)28.621.324 (24)23.816.925 (25)25.215.2Gynecologic Age at Retrieval (n)Eggs RetrievedMII Eggs0 (1)22.016.02 (2)17.011.53 (1)5.05.04 (4)23.815.06 (2)15.013.07 (2)16.014.08 (6)22.519.89 (16)24.318.210 (14)26.414.111 (12)27.419.812 (17)28.421.513 (8)22.614.114 (4)19.515.5 Open table in a new tab" @default.
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• W3092935856 date "2020-09-01" @default.
• W3092935856 modified "2023-09-27" @default.
• W3092935856 title "DOES AGE OR GYNECOLOGIC AGE AFFECT OUTCOMES OF OOCYTE CRYOPRESERVATION IN PERI-PUBERTAL AND ADOLESCENT FEMALES?" @default.
• W3092935856 doi "https://doi.org/10.1016/j.fertnstert.2020.08.645" @default.
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