FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3092938579> ?p ?o ?g. }

• W3092938579 endingPage "107085" @default.
• W3092938579 startingPage "107085" @default.
• W3092938579 abstract "Immunoglobulin A nephropathy (IgAN) is a common glomerular disease. The pathogenesis of IgAN is associated with dysregulated intestinal mucosal immunity. However, whether gut microbial modifications play a role in IgAN remains unclear. Blood and faecal samples were collected from 52 patients with IgAN and 25 healthy controls (HCs). The gut microbiome was analysed using the 16S ribosomal RNA gene. The levels of galactose-deficient IgA1 (Gd-IgA1), soluble cluster of differentiation 14 (sCD14), lipopolysaccharide binding protein (LBP), intercellular adhesion molecule-1 (ICAM-1), tumour necrosis factor α (TNF-α), interleukin-1, and C-reactive protein were quantified. Substantial differences in the gut microbiota were identified between patients with IgAN and HCs (P < 0.05). Bacteroides and Escherichia-Shigella levels were significantly higher in patients with IgAN than in HCs, while Bifidobacterium and Blautia spp. Levels were lower. Higher proportions of Escherichia-Shigella and lower proportions of Bifidobacterium spp. were observed in patients with IgAN with high urine RBC count (≥10/HP) and proteinuria (≥1 g/24 h) levels. Correlation analysis was used to assess the association between gut microbiota and biomarkers in patients with IgAN. The results showed that Prevotella 7 levels were negatively correlated with Gd-IgA1, LBP, sCD14, ICAM-1, and TNF-α levels, while Bifidobacterium spp. Levels presented a significant inverse relationship with LBP and Gd-IgA1. Additionally, Escherichia-Shigella levels were negatively correlated with Prevotella 7. In patients with IgAN, gut modifications were characterised by an increase in the number of pathogenic bacteria and a reduction in the levels of beneficial bacteria, suggesting that the disturbance of intestinal microflora might be important in the severity of IgAN." @default.
• W3092938579 created "2020-10-22" @default.
• W3092938579 creator A5021170475 @default.
• W3092938579 creator A5033560039 @default.
• W3092938579 creator A5046287063 @default.
• W3092938579 creator A5049813871 @default.
• W3092938579 creator A5068337121 @default.
• W3092938579 creator A5070323999 @default.
• W3092938579 creator A5070582496 @default.
• W3092938579 date "2020-12-01" @default.
• W3092938579 modified "2023-10-10" @default.
• W3092938579 title "Modifications of gut microbiota are associated with the severity of IgA nephropathy in the Chinese population" @default.
• W3092938579 cites W1970216382 @default.
• W3092938579 cites W1975636238 @default.
• W3092938579 cites W1985244471 @default.
• W3092938579 cites W2003838771 @default.
• W3092938579 cites W2009034382 @default.
• W3092938579 cites W2011460189 @default.
• W3092938579 cites W2030393676 @default.
• W3092938579 cites W2041677815 @default.
• W3092938579 cites W2074850565 @default.
• W3092938579 cites W2123917517 @default.
• W3092938579 cites W2124334818 @default.
• W3092938579 cites W2128976540 @default.
• W3092938579 cites W2147637673 @default.
• W3092938579 cites W2155965977 @default.
• W3092938579 cites W2525067757 @default.
• W3092938579 cites W2586394131 @default.
• W3092938579 cites W2735712510 @default.
• W3092938579 cites W2803310861 @default.
• W3092938579 cites W2883138151 @default.
• W3092938579 cites W2900796514 @default.
• W3092938579 cites W2902304754 @default.
• W3092938579 cites W2925200271 @default.
• W3092938579 cites W2940995627 @default.
• W3092938579 cites W2956498362 @default.
• W3092938579 cites W2968316112 @default.
• W3092938579 cites W2977990342 @default.
• W3092938579 cites W3012204891 @default.
• W3092938579 doi "https://doi.org/10.1016/j.intimp.2020.107085" @default.
• W3092938579 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33068859" @default.
• W3092938579 hasPublicationYear "2020" @default.
• W3092938579 type Work @default.
• W3092938579 sameAs 3092938579 @default.
• W3092938579 citedByCount "24" @default.
• W3092938579 countsByYear W30929385792021 @default.
• W3092938579 countsByYear W30929385792022 @default.
• W3092938579 countsByYear W30929385792023 @default.
• W3092938579 crossrefType "journal-article" @default.
• W3092938579 hasAuthorship W3092938579A5021170475 @default.
• W3092938579 hasAuthorship W3092938579A5033560039 @default.
• W3092938579 hasAuthorship W3092938579A5046287063 @default.
• W3092938579 hasAuthorship W3092938579A5049813871 @default.
• W3092938579 hasAuthorship W3092938579A5068337121 @default.
• W3092938579 hasAuthorship W3092938579A5070323999 @default.
• W3092938579 hasAuthorship W3092938579A5070582496 @default.
• W3092938579 hasConcept C134018914 @default.
• W3092938579 hasConcept C203014093 @default.
• W3092938579 hasConcept C2776986154 @default.
• W3092938579 hasConcept C2778168646 @default.
• W3092938579 hasConcept C2780206646 @default.
• W3092938579 hasConcept C2780305828 @default.
• W3092938579 hasConcept C2780423288 @default.
• W3092938579 hasConcept C2781065037 @default.
• W3092938579 hasConcept C2781184683 @default.
• W3092938579 hasConcept C523546767 @default.
• W3092938579 hasConcept C539455810 @default.
• W3092938579 hasConcept C54355233 @default.
• W3092938579 hasConcept C555293320 @default.
• W3092938579 hasConcept C86803240 @default.
• W3092938579 hasConcept C89423630 @default.
• W3092938579 hasConceptScore W3092938579C134018914 @default.
• W3092938579 hasConceptScore W3092938579C203014093 @default.
• W3092938579 hasConceptScore W3092938579C2776986154 @default.
• W3092938579 hasConceptScore W3092938579C2778168646 @default.
• W3092938579 hasConceptScore W3092938579C2780206646 @default.
• W3092938579 hasConceptScore W3092938579C2780305828 @default.
• W3092938579 hasConceptScore W3092938579C2780423288 @default.
• W3092938579 hasConceptScore W3092938579C2781065037 @default.
• W3092938579 hasConceptScore W3092938579C2781184683 @default.
• W3092938579 hasConceptScore W3092938579C523546767 @default.
• W3092938579 hasConceptScore W3092938579C539455810 @default.
• W3092938579 hasConceptScore W3092938579C54355233 @default.
• W3092938579 hasConceptScore W3092938579C555293320 @default.
• W3092938579 hasConceptScore W3092938579C86803240 @default.
• W3092938579 hasConceptScore W3092938579C89423630 @default.
• W3092938579 hasFunder F4320321001 @default.
• W3092938579 hasLocation W30929385791 @default.
• W3092938579 hasOpenAccess W3092938579 @default.
• W3092938579 hasPrimaryLocation W30929385791 @default.
• W3092938579 hasRelatedWork W2045833477 @default.
• W3092938579 hasRelatedWork W2109759565 @default.
• W3092938579 hasRelatedWork W2112890441 @default.
• W3092938579 hasRelatedWork W2755088210 @default.
• W3092938579 hasRelatedWork W2896002827 @default.
• W3092938579 hasRelatedWork W2929298853 @default.
• W3092938579 hasRelatedWork W3027274542 @default.
• W3092938579 hasRelatedWork W3171485143 @default.

• next