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- W3092959890 abstract "Nonalcoholic fatty liver disease (NAFLD) is a burgeoning public health problem worldwide. Despite its tremendous significance for public health, we lack a comprehensive understanding of the pathogenic mechanisms of NAFLD and its more advanced stage, nonalcoholic steatohepatitis (NASH). Identification of novel pathways or cellular mechanisms that regulate liver lipid metabolism has profound implications for the understanding of the pathology of NAFLD and NASH. The nuclear envelope is topologically connected to the ER, where protein synthesis and lipid synthesis occurs. Emerging evidence points toward that the nuclear lamins and nuclear membrane-associated proteins are involved in lipid metabolism and homeostasis. We review published reports that link these nuclear envelope proteins to lipid metabolism. In particular, we focus on the recent work demonstrating the essential roles for the nuclear envelope-localized torsinA/lamina-associated polypeptide (LAP1) complex in hepatic steatosis, lipid secretion, and NASH development. We also discuss plausible pathogenic mechanisms by which the loss of either protein in hepatocytes leads to hepatic dyslipidemia and NASH development." @default.
- W3092959890 created "2020-10-22" @default.
- W3092959890 creator A5013255588 @default.
- W3092959890 creator A5037581308 @default.
- W3092959890 creator A5081836451 @default.
- W3092959890 date "2020-10-15" @default.
- W3092959890 modified "2023-10-18" @default.
- W3092959890 title "The Nuclear Envelope in Lipid Metabolism and Pathogenesis of NAFLD" @default.
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