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- W3092994586 endingPage "336" @default.
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- W3092994586 abstract "The three-dimensional (3D) organization of the genome is a crucial enabler of cell fate, identity, and function. In this review, we will focus on the emerging role of altered 3D genome organization in the etiology of disease, with a special emphasis on brain cancers. We discuss how different genetic alterations can converge to disrupt the epigenome in childhood and adult brain tumors, by causing aberrant DNA methylation and by affecting the amounts and genomic distribution of histone post-translational modifications. We also highlight examples that illustrate how epigenomic alterations have the potential to affect 3D genome architecture in brain tumors. Finally, we will propose the concept of “epigenomic erosion” to explain the transition from stem-like cells to differentiated cells in hierarchically organized brain cancers." @default.
- W3092994586 created "2020-10-22" @default.
- W3092994586 creator A5006060509 @default.
- W3092994586 creator A5058469735 @default.
- W3092994586 creator A5074271280 @default.
- W3092994586 date "2021-04-01" @default.
- W3092994586 modified "2023-09-27" @default.
- W3092994586 title "Dysregulation of chromatin organization in pediatric and adult brain tumors: oncoepigenomic contributions to tumorigenesis and cancer stem cell properties" @default.
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- W3092994586 doi "https://doi.org/10.1139/gen-2020-0097" @default.