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- W3092997796 abstract "Tacrolimus and cyclosporin are both calcineurin inhibitors (CNIs) recommended as first-line immunosuppressants for solid organ transplantation, we aim to compare the influences of tacrolimus and cyclosporin on pregnancy outcomes for female transplant recipients. Systematically review of observational studies comparing pregnancy outcomes of tacrolimus and cyclosporin as primary immunosuppression after solid organ transplantation. A comprehensive literature search was conducted between January 1, 2000 and March 20, 2020 according to the database of PubMed, EMBASE, and Web of Science. The following combination of text terms was searched in [Title]: Transplant / Transplants / Grafts / Graft / Transplantations / Transplantation, and Pregnancy / Pregnancies / Gestation / Pregnant / Gravidity / Gravidities. Weighted mean difference (WMD) and odds ratio (OR) was calculated to compare continuous and dichotomous variables respectively with 95% confidence intervals (CIs). Publication bias was estimated by funnel plots. Quality of study was assessed according to the modified Newcastle-Ottawa scale. 24 observational studies including a total of 1492 pregnant post-transplant recipients were identified in our analysis. Tacrolimus-treated recipients experienced lower risk of gestational hypertension (44.6% vs 29.0%; OR:1.58; 95% CI,1.20-2.08; P < 0.01) and infections (24.7% vs 13.6%; OR:1.87; 95% CI, 1.25-2.80; P < 0.01). Cyclosporin-treated recipients showed a lower incidence of abortions (16.7% vs 25.5%; OR: 0.59; 95% CI, 0.41-0.86; P < 0.01), gestational diabetes (2.3% vs 9.3%; OR: 0.24; 95% CI, 0.13-0.44; P < 0.00001) and cesarean section (41.7% vs 48.8%; OR:0.71; 95% CI, 0.54-0.93; P = 0.01). Additionally, cyclosporin performed better regarding the live birth rate (78.4% vs 70.8%; OR: 1.43; 95% CI, 1.08-1.87; P = 0.01). There were no significant differences in the incidences of preeclampsia, postpartum rejection, preterm delivery and low birth weight. Cyclosporin is safer in delivery outcomes, while tacrolimus is associated with lower risk of maternal complications except gestational diabetes." @default.
- W3092997796 created "2020-10-22" @default.
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- W3092997796 date "2020-09-01" @default.
- W3092997796 modified "2023-09-30" @default.
- W3092997796 title "PREGNANCY OUTCOMES IN FEMALE PATIENTS EXPOSING TO CYCLOSPORIN VERSUS TACROLIMUS AS PRIMARY IMMUNOSUPPRESSION AFTER SOLID ORGAN TRANSPLANTATION: A SYSTEMATIC REVIEW AND META-ANALYSIS" @default.
- W3092997796 doi "https://doi.org/10.1016/j.fertnstert.2020.09.079" @default.
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