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• W3093009519 abstract "To examine the cross-sectional associations between dietary patterns and cognitive and neuroimaging indices of brain health concurrently in the same sample of healthy older adults. Dietary patterns were derived from a 130-item food frequency questionnaire for 511 individuals in the Lothian Birth Cohort 1936 (mean age 79.3 ± 0.6 years). Composite scores for global cognitive function, visuospatial ability, processing speed, memory, and verbal ability were assessed. Brain volumes and white matter microstructure were assessed in participants (n = 358) who also underwent structural magnetic resonance imaging. A Mediterranean-style dietary pattern and a processed dietary pattern were identified using principal component analysis of food frequency questionnaire items. In fully-adjusted linear regression models, adherence to the Mediterranean-style pattern was associated with better verbal ability (β = 0.121, P = 0.002). Associations with global cognitive function (β = 0.094, P = 0.043), visuospatial ability (β = 0.113, P = 0.019), and memory (β = 0.105, P = 0.029) did not survive correction for multiple comparisons. Associations between the processed pattern and lower cognitive scores were attenuated by around 50% following adjustment for prior (childhood) cognitive ability; only an association with verbal ability remained (β = −0.130, P = 0.001). Neither dietary pattern was associated with brain volumes or white matter microstructure. Specific Mediterranean diet features—green leafy vegetables and a low intake of red meat—were associated with better cognitive functioning. These observational findings suggest that adherence to a Mediterranean-style diet is associated with better cognitive functioning, but not better brain structural integrity, in older adults." @default.
• W3093009519 created "2020-10-22" @default.
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• W3093009519 date "2020-12-01" @default.
• W3093009519 modified "2023-10-18" @default.
• W3093009519 title "Dietary patterns, cognitive function, and structural neuroimaging measures of brain aging" @default.
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• W3093009519 doi "https://doi.org/10.1016/j.exger.2020.111117" @default.
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