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- W3093061330 abstract "To study whether varicocele affects the metabolism of semen and whether microsurgical varicocelectomy can reverse the metabolism of semen. A origina article. The semen samples from 30 varicocele patients, 30 patients after microsurgical varicocelectomy, and 30 healthy males were selected to conduct non-targeted metabolomics by liquid chromatography-mass spectrometry. Different metabolites between three groups were analyzed and the metabolic pathways were analyzed by KEGG database. Potential biomarkers were determined by t-test and receiver operating characteristic (ROC) curve analysis. 275 different expressed metabolites involving in 39 pathways were found between varicocele group and normal group. A total of 8 metabolites were selected as varicocele potential biomarkers by HPLC-QE-MS high-throughput untargeted metabolomics analyses [Area under the curve (AUC)>0.90]. Varicocele influence semen quality through amino acids metabolism, reactive oxygen species and anti-oxidation relative metabolism, phenylalanine, tyrosine and tryptophan biosynthesis pathway and phenylalanine metabolism pathway. Microsurgical varicocelectomy may improve semen quality by rebalancing dipeptide metabolism which has an antioxidant effect, and regulating ceramide and Sphingolipid metabolism, which is associated with ROS production, oxidative stress, mitochondrial respiratory chain, mitophagy and apoptosis. These results suggested that varicocele could change the sperm metabolism, and microsurgical varicocelectomy could improve the sperm quality by changing the sperm metabolism. Further study is needed!" @default.
- W3093061330 created "2020-10-22" @default.
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- W3093061330 date "2020-09-01" @default.
- W3093061330 modified "2023-10-18" @default.
- W3093061330 title "THE INFLUENCE OF VARICOCELE AND MICROSURGICAL VARICOCELECTOMY ON SEMEN QUALITY: A UHPLC-QE-MS UNTARGETED METABOLIC ANALYSIS" @default.
- W3093061330 doi "https://doi.org/10.1016/j.fertnstert.2020.08.1104" @default.
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