Matches in SemOpenAlex for { <https://semopenalex.org/work/W3093062977> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W3093062977 abstract "Aim: One of the aims of the Observation Health Data Sciences and Informatics (OHDSI) initiative is population-level treatment effect estimation in large observational databases. Since treatment effects are well-known to vary across groups of patients with different baseline risk, we aimed to extend the OHDSI methods library with a framework for risk-based assessment of treatment effect heterogeneity. Materials and Methods: The proposed framework consists of five steps: 1) definition of the problem, i.e. the population, the treatment, the comparator and the outcome(s) of interest; 2) identification of relevant databases; 3) development of a prediction model for the outcome(s) of interest; 4) estimation of propensity scores within strata of predicted risk and estimation of relative and absolute treatment effect within strata of predicted risk; 5) evaluation and presentation of results. Results: We demonstrate our framework by evaluating heterogeneity of the effect of angiotensin-converting enzyme (ACE) inhibitors versus beta blockers on a set of 9 outcomes of interest across three observational databases. With increasing risk of acute myocardial infarction we observed increasing absolute benefits, i.e. from -0.03% to 0.54% in the lowest to highest risk groups. Cough-related absolute harms decreased from 4.1% to 2.6%. Conclusions: The proposed framework may be useful for the evaluation of heterogeneity of treatment effect on observational data that are mapped to the OMOP Common Data Model. The proof of concept study demonstrates its feasibility in large observational data. Further insights may arise by application to safety and effectiveness questions across the global data network." @default.
- W3093062977 created "2020-10-22" @default.
- W3093062977 creator A5004074611 @default.
- W3093062977 creator A5006559598 @default.
- W3093062977 creator A5048645102 @default.
- W3093062977 creator A5065153070 @default.
- W3093062977 creator A5090900073 @default.
- W3093062977 creator A5091435927 @default.
- W3093062977 date "2020-10-14" @default.
- W3093062977 modified "2023-09-25" @default.
- W3093062977 title "A standardized framework for risk-based assessment of treatment effect heterogeneity in observational healthcare databases" @default.
- W3093062977 cites W1573555636 @default.
- W3093062977 cites W1581514961 @default.
- W3093062977 cites W1893697707 @default.
- W3093062977 cites W1966220462 @default.
- W3093062977 cites W1994682257 @default.
- W3093062977 cites W2002456705 @default.
- W3093062977 cites W2006290997 @default.
- W3093062977 cites W2066071728 @default.
- W3093062977 cites W2113972884 @default.
- W3093062977 cites W2128780239 @default.
- W3093062977 cites W2133416234 @default.
- W3093062977 cites W2143096867 @default.
- W3093062977 cites W2164821482 @default.
- W3093062977 cites W2473310816 @default.
- W3093062977 cites W2515858651 @default.
- W3093062977 cites W2748099698 @default.
- W3093062977 cites W2770837559 @default.
- W3093062977 cites W2789966595 @default.
- W3093062977 cites W2799695199 @default.
- W3093062977 cites W2808880546 @default.
- W3093062977 cites W2904040183 @default.
- W3093062977 cites W2952356497 @default.
- W3093062977 cites W2981330642 @default.
- W3093062977 cites W2984947744 @default.
- W3093062977 cites W2986406995 @default.
- W3093062977 cites W2986844826 @default.
- W3093062977 cites W3023969949 @default.
- W3093062977 cites W34678172 @default.
- W3093062977 doi "https://doi.org/10.5281/zenodo.4087989" @default.
- W3093062977 hasPublicationYear "2020" @default.
- W3093062977 type Work @default.
- W3093062977 sameAs 3093062977 @default.
- W3093062977 citedByCount "0" @default.
- W3093062977 crossrefType "posted-content" @default.
- W3093062977 hasAuthorship W3093062977A5004074611 @default.
- W3093062977 hasAuthorship W3093062977A5006559598 @default.
- W3093062977 hasAuthorship W3093062977A5048645102 @default.
- W3093062977 hasAuthorship W3093062977A5065153070 @default.
- W3093062977 hasAuthorship W3093062977A5090900073 @default.
- W3093062977 hasAuthorship W3093062977A5091435927 @default.
- W3093062977 hasBestOaLocation W30930629771 @default.
- W3093062977 hasConcept C126322002 @default.
- W3093062977 hasConcept C160735492 @default.
- W3093062977 hasConcept C162324750 @default.
- W3093062977 hasConcept C23131810 @default.
- W3093062977 hasConcept C41008148 @default.
- W3093062977 hasConcept C50522688 @default.
- W3093062977 hasConcept C71924100 @default.
- W3093062977 hasConcept C77088390 @default.
- W3093062977 hasConceptScore W3093062977C126322002 @default.
- W3093062977 hasConceptScore W3093062977C160735492 @default.
- W3093062977 hasConceptScore W3093062977C162324750 @default.
- W3093062977 hasConceptScore W3093062977C23131810 @default.
- W3093062977 hasConceptScore W3093062977C41008148 @default.
- W3093062977 hasConceptScore W3093062977C50522688 @default.
- W3093062977 hasConceptScore W3093062977C71924100 @default.
- W3093062977 hasConceptScore W3093062977C77088390 @default.
- W3093062977 hasLocation W30930629771 @default.
- W3093062977 hasLocation W30930629772 @default.
- W3093062977 hasOpenAccess W3093062977 @default.
- W3093062977 hasPrimaryLocation W30930629771 @default.
- W3093062977 hasRelatedWork W2317981192 @default.
- W3093062977 hasRelatedWork W2322181765 @default.
- W3093062977 hasRelatedWork W2374348909 @default.
- W3093062977 hasRelatedWork W2376987262 @default.
- W3093062977 hasRelatedWork W2595608501 @default.
- W3093062977 hasRelatedWork W2748952813 @default.
- W3093062977 hasRelatedWork W2765980456 @default.
- W3093062977 hasRelatedWork W2899084033 @default.
- W3093062977 hasRelatedWork W2976382042 @default.
- W3093062977 hasRelatedWork W3031052312 @default.
- W3093062977 isParatext "false" @default.
- W3093062977 isRetracted "false" @default.
- W3093062977 magId "3093062977" @default.
- W3093062977 workType "article" @default.