FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3093148975> ?p ?o ?g. }

• W3093148975 endingPage "77" @default.
• W3093148975 startingPage "66" @default.
• W3093148975 abstract "Immune checkpoint inhibitors (ICIs) are increasingly used to treat cancers. Kidney immune-related adverse events (IRAEs) are now well recognized, with the incidence of IRAEs ranging from 2% to 5%. Most of the initial data related to kidney IRAEs have focused on acute interstitial nephritis (AIN). There are minimal data on the types and relative frequencies of glomerular diseases associated with ICIs, their treatment, and outcomes.We performed a systematic review and meta-analysis of all biopsy-proven published cases/series of glomerular pathology associated with ICIs. We searched the MEDLINE, EMBASE, and Cochrane databases from inception to February 2020. We abstracted patient-level data, including demographics, cancer and ICI therapy details, and characteristics of kidney injury.After screening, 27 articles with 45 cases of biopsy-confirmed ICI-associated glomerular disease were identified. Several lesion types were observed, with the most frequent being pauci-immune glomerulonephritis (GN) and renal vasculitis (27%), podocytopathies (24%), and complement 3 GN (C3GN; 11%). Concomitant AIN was reported in 41%. Most patients had ICIs discontinued (88%), and nearly all received corticosteroid treatment (98%). Renal replacement therapy (RRT) was required in 25%. Most patients had full (31%) or partial (42%) recovery from acute kidney injury (AKI), although 19% remained dialysis-dependent, and approximately one-third died. Complete or partial remission of proteinuria was achieved in 45% and 38%, respectively.Multiple forms of ICI-associated glomerular disease have been described. Pauci-immune GN, podocytopathies, and C3GN are the most frequently reported lesions. ICI-associated glomerular disease may be associated with poor kidney and mortality outcomes. Oncologists and nephrologists must be aware of glomerular pathologies associated with ICIs and consider obtaining a kidney biopsy specimen when features atypical for AIN are present." @default.
• W3093148975 created "2020-10-22" @default.
• W3093148975 creator A5018399640 @default.
• W3093148975 creator A5019045698 @default.
• W3093148975 creator A5040646631 @default.
• W3093148975 creator A5049148114 @default.
• W3093148975 creator A5056937094 @default.
• W3093148975 creator A5081327452 @default.
• W3093148975 creator A5081788360 @default.
• W3093148975 creator A5085929764 @default.
• W3093148975 date "2021-01-01" @default.
• W3093148975 modified "2023-10-11" @default.
• W3093148975 title "A Systematic Review of Immune Checkpoint Inhibitor–Associated Glomerular Disease" @default.
• W3093148975 cites W1971989824 @default.
• W3093148975 cites W1982488143 @default.
• W3093148975 cites W2017169228 @default.
• W3093148975 cites W2156098321 @default.
• W3093148975 cites W2163332095 @default.
• W3093148975 cites W2169794517 @default.
• W3093148975 cites W2222086386 @default.
• W3093148975 cites W2269483232 @default.
• W3093148975 cites W2338242614 @default.
• W3093148975 cites W2413514895 @default.
• W3093148975 cites W246286872 @default.
• W3093148975 cites W2507938301 @default.
• W3093148975 cites W2513779458 @default.
• W3093148975 cites W2516962890 @default.
• W3093148975 cites W2550815089 @default.
• W3093148975 cites W2557098519 @default.
• W3093148975 cites W2560367415 @default.
• W3093148975 cites W2562022483 @default.
• W3093148975 cites W2563267837 @default.
• W3093148975 cites W2572174216 @default.
• W3093148975 cites W2599077683 @default.
• W3093148975 cites W2722553159 @default.
• W3093148975 cites W2735725443 @default.
• W3093148975 cites W2736263260 @default.
• W3093148975 cites W2757853014 @default.
• W3093148975 cites W2765564427 @default.
• W3093148975 cites W2781250287 @default.
• W3093148975 cites W2781601010 @default.
• W3093148975 cites W2783137027 @default.
• W3093148975 cites W2783826483 @default.
• W3093148975 cites W2785755264 @default.
• W3093148975 cites W2786816161 @default.
• W3093148975 cites W2804347511 @default.
• W3093148975 cites W2808003286 @default.
• W3093148975 cites W2809202750 @default.
• W3093148975 cites W2810305280 @default.
• W3093148975 cites W2883863660 @default.
• W3093148975 cites W2891104720 @default.
• W3093148975 cites W2899478379 @default.
• W3093148975 cites W2902421706 @default.
• W3093148975 cites W2903686952 @default.
• W3093148975 cites W2910390119 @default.
• W3093148975 cites W2914287567 @default.
• W3093148975 cites W2914604561 @default.
• W3093148975 cites W2914696936 @default.
• W3093148975 cites W2923561750 @default.
• W3093148975 cites W2924070172 @default.
• W3093148975 cites W2936682755 @default.
• W3093148975 cites W2949334838 @default.
• W3093148975 cites W2950422974 @default.
• W3093148975 cites W2965000162 @default.
• W3093148975 cites W2969665548 @default.
• W3093148975 cites W2971946316 @default.
• W3093148975 cites W2975636330 @default.
• W3093148975 cites W2979299948 @default.
• W3093148975 cites W2980001423 @default.
• W3093148975 cites W2981381556 @default.
• W3093148975 cites W2981911914 @default.
• W3093148975 cites W2984413960 @default.
• W3093148975 cites W2994168467 @default.
• W3093148975 cites W2996424102 @default.
• W3093148975 cites W2997561837 @default.
• W3093148975 cites W2999634998 @default.
• W3093148975 cites W2999959360 @default.
• W3093148975 cites W3005678401 @default.
• W3093148975 cites W3006479182 @default.
• W3093148975 cites W3006610635 @default.
• W3093148975 cites W3010579821 @default.
• W3093148975 cites W3012183696 @default.
• W3093148975 cites W4294215472 @default.
• W3093148975 doi "https://doi.org/10.1016/j.ekir.2020.10.002" @default.
• W3093148975 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7783581" @default.
• W3093148975 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33426386" @default.
• W3093148975 hasPublicationYear "2021" @default.
• W3093148975 type Work @default.
• W3093148975 sameAs 3093148975 @default.
• W3093148975 citedByCount "73" @default.
• W3093148975 countsByYear W30931489752021 @default.
• W3093148975 countsByYear W30931489752022 @default.
• W3093148975 countsByYear W30931489752023 @default.
• W3093148975 crossrefType "journal-article" @default.
• W3093148975 hasAuthorship W3093148975A5018399640 @default.
• W3093148975 hasAuthorship W3093148975A5019045698 @default.
• W3093148975 hasAuthorship W3093148975A5040646631 @default.
• W3093148975 hasAuthorship W3093148975A5049148114 @default.

• next