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- W3093168568 abstract "The design and development of new pharmaceutical formulations for the existing anti-leishmanial is a new strategic alternate to improve efficacy and safety rather than new drug discovery. Herein hybrid solid lipid nanoparticles (SLN) have been engineered to direct the oral delivery of two anti-leishmanial drugs amphotericin B (AmB) and paromomycin (PM). The combinatorial nanocarriers consist of conventional SLN, antileishmanial drugs (AmB and PM) which have been functionalized with chitosan (Cs) grafted onto the external surface. The Cs-SLN have mean particle size of 373.9 ±1.41 nm, polydispersity index (PDI) of 0.342±0.02 and the entrapment efficiency for AmB and PM was found to be 95.20±3.19 % and 89.45± 6.86 % respectively. Characterization of SLN was performed by scanning electron microscopy and transmission electron microscopy. Complete internalization of the formulation was observed in Caco-2 cells. Cs-SLN have shown a controlled and slow drug release profile over a period of 72 hrs and was stable at gastrointestinal fluids, confirmed by in vitro simulated gastro-intestinal fluid study. Cs coating enhanced the mucoadhesive property of Cs-SLN. The in-vitro anti-leishmanial activity of Cs-SLN (1µg/ml) has shown a maximum percentage of inhibition (92.35% and 89% respectively) on intra-cellular amastigote growth of L. donovani." @default.
- W3093168568 created "2020-10-22" @default.
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- W3093168568 date "2020-10-15" @default.
- W3093168568 modified "2023-10-03" @default.
- W3093168568 title "Recuperating Biopharmaceutical Aspects of Amphotericin B and Paromomycin Using a Chitosan Functionalized Nanocarrier via Oral Route for Enhanced Anti-leishmanial Activity" @default.
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- W3093168568 doi "https://doi.org/10.3389/fcimb.2020.570573" @default.
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