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- W3093185696 abstract "Abstract Understanding whether and how temperature increases alter the effects of mutations on protein stability is crucial for understanding the limits to thermal adaptation by organisms. Currently, it is generally assumed that the stability effects of mutations are independent of temperature. Yet, mutations should become increasingly destabilizing as temperature rises due to the increase in the energy of atoms. Here, by performing an extensive computational analysis on the essential enzyme adenylate kinase in prokaryotes, we show, for the first time, that mutations become more destabilizing with temperature both across and within species. Consistent with these findings, we find that substitution rates of prokaryotes decrease nonlinearly with temperature. Our results suggest that life on Earth likely originated in a moderately thermophilic and thermally fluctuating environment, and indicate that global warming should decrease the per-generation rate of molecular evolution of prokaryotes." @default.
- W3093185696 created "2020-10-22" @default.
- W3093185696 creator A5040718454 @default.
- W3093185696 creator A5057819378 @default.
- W3093185696 creator A5062486271 @default.
- W3093185696 creator A5085878905 @default.
- W3093185696 date "2020-10-14" @default.
- W3093185696 modified "2023-10-15" @default.
- W3093185696 title "Higher temperatures worsen the effects of mutations on protein stability" @default.
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- W3093185696 doi "https://doi.org/10.1101/2020.10.13.337972" @default.
- W3093185696 hasPublicationYear "2020" @default.