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- W3093193670 abstract "Abstract Next generation life science technologies will require the integration of building blocks with tunable physical and chemical architectures at the microscale. A central issue is to govern the multidimensional anisotropic space that defines these microparticle attributes. However, this control is limited to one or few dimensions due to profound fabrication tradeoffs, a problem that is exacerbated by miniaturization. Here, a vast number of anisotropic dimensions are integrated combining SU‐8 photolithography with (bio)chemical modifications via soft‐lithography. Microparticles in a 15‐D anisotropic space are demonstrated, covering branching, faceting, fiducial, topography, size, aspect ratio, stiffness, (bio)molecular and quantum dot printing, top/bottom surface coverage, and quasi‐ 0D, 1D, 2D, and 3D surface patterning. The strategy permits controlled miniaturization on physical dimensions below 1 µm and molecular patterns below 1 µm 2 . By combining building blocks, anisotropic microparticles detect pH changes, form the basis for a DNA‐assay recognition platform, and obtain an extraordinary volumetric barcoding density up to 1093 codes µm −3 in a 3 × 12 × 0.5 µm 3 volume." @default.
- W3093193670 created "2020-10-22" @default.
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- W3093193670 date "2020-10-20" @default.
- W3093193670 modified "2023-10-14" @default.
- W3093193670 title "Multidimensional Anisotropic Architectures on Polymeric Microparticles" @default.
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- W3093193670 doi "https://doi.org/10.1002/smll.202004691" @default.
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