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- W3093196235 abstract "Glioblastoma (GBM) recurrence is attributed to the presence of therapy-resistant glioblastoma stem cells. Steroid receptor coactivator-1 (SRC-1) acts as an oncogenic regulator in many human tumors. The relationship between SRC-1 and GBM has not yet been studied. Herein, we investigate the role of SRC-1 in GBM. In this study, we found that SRC-1 expression is positively correlated with grades of glioma and inversely correlated with glioma patient’s prognosis. Steroid receptor coactivator-1 promotes the proliferation, migration, and tumor growth of GBM cells. Notably, SRC-1 knockdown suppresses the stemness of GBM cells. Mechanistically, long noncoding RNA X-inactive specific transcript (XIST) is regulated by SRC-1 at the posttranscriptional level and mediates the function of SRC-1 in promoting stemness-like properties of GBM. Steroid receptor coactivator-1 can promote the expression of Kruppel-like factor 4 (KLF4) through the XIST/microRNA (miR)-152 axis. Additionally, arenobufagin and bufalin, SRC small molecule inhibitors, can reduce the proliferation and stemness of GBM cells. This study reveals SRC-1 promotes the stemness of GBM by activating the long noncoding RNA XIST/miR-152/KLF4 pathway and provides novel markers for diagnosis and therapy of GBM." @default.
- W3093196235 created "2020-10-22" @default.
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- W3093196235 date "2020-12-14" @default.
- W3093196235 modified "2023-10-15" @default.
- W3093196235 title "Steroid receptor coactivator‐1 enhances the stemness of glioblastoma by activating long noncoding RNA XIST/miR‐152/KLF4 pathway" @default.
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- W3093196235 doi "https://doi.org/10.1111/cas.14685" @default.
- W3093196235 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7894023" @default.
- W3093196235 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33090636" @default.