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• W3093227814 abstract "SESSION TITLE: Obstructive Lung Disease Posters SESSION TYPE: Original Investigation Posters PRESENTED ON: October 18-21, 2020 PURPOSE: Obstructive lung diseases (OLD) affect women disproportionately with higher risk of disease development and greater symptom burden. Female reproductive hormones, namely estrogen and progesterone, have been implicated as mediators in lung physiology as women advance in their reproductive lifespan. However, conflicting evidence exists on the effects of hormonal changes during menopause on lung function. We therefore studied the effect of bilateral oophorectomy (BO) on the development of OLD. METHODS: The Rochester Epidemiology Project (REP) medical records-linkage system was used to identify all premenopausal women who underwent BO for benign indications before age 50, between 1988 and 2007 in Olmsted County, Minnesota (N=1,653). Each woman was randomly matched to a referent woman born in the same year (+/-1) who had not undergone BO (N=1,653). OLD diagnostic codes were obtained from REP electronic indexes. Medical records were reviewed through 12/31/2018. Global Initiative for Chronic OLD (GOLD) and Global Initiative for Asthma (GINA) 2019 definitions were used to classify OLD on pulmonary function testing. Radiologist-interpreted reports were used to evaluate changes on computed tomography. Each woman could have more than one type of OLD. Hazard ratios were derived from Cox proportional hazards models adjusted for chronic conditions and other possible confounders at the index date, separately for each type of OLD (asthma, chronic obstructive pulmonary disease [COPD], emphysema without documented airflow limitation, or chronic bronchitis). RESULTS: Over a median of 18 years of follow up, de novo OLD was identified in 259 women who underwent BO (219 asthma, 15 COPD, 19 emphysema, 60 chronic bronchitis) and 202 referent women (168 asthma, 15 COPD, 13 emphysema, 36 chronic bronchitis). Women who underwent BO had a higher risk of asthma overall (HR 1.23, 95% CI 1.01-1.51). This was most notable in younger women age ≤45 years at BO (HR 1.54, 95% CI 1.19-1.99), especially those who did not receive estrogen treatment (ET) (HR 2.49, 95% CI 1.08-5.75). No significant risk of COPD (HR 1.01, 95% CI 0.49-2.10), emphysema (HR 1.29, 95% CI 0.66-2.53), or chronic bronchitis (HR 1.41, 95% 0.94-2.13) was found. CONCLUSIONS: Women who underwent BO, especially young women ≤45 years of age and those who did not receive ET, had an increased risk of asthma. CLINICAL IMPLICATIONS: Some studies suggest that as sex hormones wane in natural menopause, there is a decreased risk of asthma, and that ET may increase the risk. However, other studies suggest that menopause is associated with lower lung function and worse asthma symptom severity. This study suggests that age of onset of menopause and ET may influence the risks of asthma. Although a clear sexual dimorphism in airway pathology exists, further investigation is warranted to understand the impact of hormonal changes on lung pathology. DISCLOSURES: No relevant relationships by Megan Dulohery Scrodin, source=Web Response No relevant relationships by Trinh Nguyen, source=Web Response No relevant relationships by Walter Rocca, source=Web Response No relevant relationships by Carin Smith, source=Web Response Recipient of grant funding relationship with Bristol Myers Squibb Please note: >$100000 Added 03/23/2020 by Robert Vassallo, source=Web Response, value=Grant/Research Support Recipient of grant funding relationship with Sun Pharmaceuticals Please note: >$100000 Added 03/23/2020 by Robert Vassallo, source=Web Response, value=Grant/Research Support Recipient of grant funding relationship with Pfizer Please note: >$100000 Added 03/23/2020 by Robert Vassallo, source=Web Response, value=Grant/Research Support" @default.
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• W3093227814 date "2020-10-01" @default.
• W3093227814 modified "2023-09-25" @default.
• W3093227814 title "RISK FOR OBSTRUCTIVE LUNG DISEASE DEVELOPMENT AFTER BILATERAL OOPHORECTOMY" @default.
• W3093227814 doi "https://doi.org/10.1016/j.chest.2020.08.1532" @default.
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