FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3093241002> ?p ?o ?g. }

• W3093241002 endingPage "209" @default.
• W3093241002 startingPage "199" @default.
• W3093241002 abstract "To investigate the beneficial effect of brain-derived neurotrophic factor (BDNF) -overexpressing human umbilical cord mesenchymal stem cell (hUC-MSC)-derived motor neurons in the human Cu, Zn-superoxide dismutase1 (hSOD1)G93A amyotrophic lateral sclerosis (ALS) mice.The BDNF gene was transfected into hUC-MSC-derived motor neurons by the lentivirus-mediated method. hSOD1G93A mice were assigned to the ALS, ALS/MN, and ALS/MN-BDNF groups, and intrathecally administrated phosphate-buffered saline (PBS), motor neurons, or motor neurons overexpressing BDNF, respectively. The control group included non-transgenic wild-type littermates administrated PBS. One month after transplantation, the motor function of the mice was assessed by the rotarod test, and the lumbar enlargements were then isolated to detect the expression of hSOD1 and BDNF by western blotting, and the expression of choline acetyltransferase (ChAT), homeobox protein 9 (HB9), major histocompatibility complex I (MHCI) and microtubule-associated protein-2 (MAP-2) by immunofluorescence assay.After transplantation, mice in the ALS/MN-BDNF and ALS/MN groups both exhibited longer latency to fall and longer survival than those in the ALS group (P < 0.01 vs. P < 0.05), and the improvement was more significant in the former than in the latter. However, cell transplantation did not delay disease onset. In the lumbar enlargements of the ALS/MN-BDNF and ALS/MN groups, the expression of hSOD1 was slightly reduced without statistical significance (P > 0.05), but the expression of BDNF, ChAT and HB9, and the co-expression of MHCI and MAP-2 were significantly greater than in the ALS group (P < 0.01), with the differences also being more prominent in the former group than in the latter.Transplantation of BDNF-overexpressing hUC-MSC-derived motor neurons can improve motor performance and prolong the survival of hSOD1G93A mice. Combining stem cell-derived motor neurons with BDNF might provide a new therapeutic strategy for ALS." @default.
• W3093241002 created "2020-10-22" @default.
• W3093241002 creator A5026070862 @default.
• W3093241002 creator A5070944079 @default.
• W3093241002 creator A5075877965 @default.
• W3093241002 creator A5082461258 @default.
• W3093241002 date "2020-10-19" @default.
• W3093241002 modified "2023-09-24" @default.
• W3093241002 title "BDNF-overexpressing human umbilical cord mesenchymal stem cell-derived motor neurons improve motor function and prolong survival in amyotrophic lateral sclerosis mice" @default.
• W3093241002 cites W1613946354 @default.
• W3093241002 cites W1805838114 @default.
• W3093241002 cites W1921779421 @default.
• W3093241002 cites W1964372429 @default.
• W3093241002 cites W1971386958 @default.
• W3093241002 cites W1979285653 @default.
• W3093241002 cites W2007035942 @default.
• W3093241002 cites W2008452978 @default.
• W3093241002 cites W2018843440 @default.
• W3093241002 cites W2022984493 @default.
• W3093241002 cites W2034445101 @default.
• W3093241002 cites W2039253350 @default.
• W3093241002 cites W2049766904 @default.
• W3093241002 cites W2050946454 @default.
• W3093241002 cites W2051809578 @default.
• W3093241002 cites W2070542281 @default.
• W3093241002 cites W2073864172 @default.
• W3093241002 cites W2091389527 @default.
• W3093241002 cites W2096386031 @default.
• W3093241002 cites W2104109524 @default.
• W3093241002 cites W2129411138 @default.
• W3093241002 cites W2149428117 @default.
• W3093241002 cites W2157076525 @default.
• W3093241002 cites W2171709048 @default.
• W3093241002 cites W2172180689 @default.
• W3093241002 cites W2239139271 @default.
• W3093241002 cites W2290753804 @default.
• W3093241002 cites W2345609685 @default.
• W3093241002 cites W2511420689 @default.
• W3093241002 cites W2768680758 @default.
• W3093241002 cites W2802796971 @default.
• W3093241002 cites W2906413711 @default.
• W3093241002 cites W2964119352 @default.
• W3093241002 cites W3031622138 @default.
• W3093241002 cites W3093708335 @default.
• W3093241002 cites W4252979096 @default.
• W3093241002 doi "https://doi.org/10.1080/01616412.2020.1834775" @default.
• W3093241002 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33076784" @default.
• W3093241002 hasPublicationYear "2020" @default.
• W3093241002 type Work @default.
• W3093241002 sameAs 3093241002 @default.
• W3093241002 citedByCount "15" @default.
• W3093241002 countsByYear W30932410022021 @default.
• W3093241002 countsByYear W30932410022022 @default.
• W3093241002 countsByYear W30932410022023 @default.
• W3093241002 crossrefType "journal-article" @default.
• W3093241002 hasAuthorship W3093241002A5026070862 @default.
• W3093241002 hasAuthorship W3093241002A5070944079 @default.
• W3093241002 hasAuthorship W3093241002A5075877965 @default.
• W3093241002 hasAuthorship W3093241002A5082461258 @default.
• W3093241002 hasConcept C126322002 @default.
• W3093241002 hasConcept C134018914 @default.
• W3093241002 hasConcept C160539049 @default.
• W3093241002 hasConcept C169760540 @default.
• W3093241002 hasConcept C170493617 @default.
• W3093241002 hasConcept C198399640 @default.
• W3093241002 hasConcept C2776752467 @default.
• W3093241002 hasConcept C2778790584 @default.
• W3093241002 hasConcept C2779134260 @default.
• W3093241002 hasConcept C2780596555 @default.
• W3093241002 hasConcept C2780775167 @default.
• W3093241002 hasConcept C2911091166 @default.
• W3093241002 hasConcept C529278444 @default.
• W3093241002 hasConcept C71924100 @default.
• W3093241002 hasConcept C86803240 @default.
• W3093241002 hasConceptScore W3093241002C126322002 @default.
• W3093241002 hasConceptScore W3093241002C134018914 @default.
• W3093241002 hasConceptScore W3093241002C160539049 @default.
• W3093241002 hasConceptScore W3093241002C169760540 @default.
• W3093241002 hasConceptScore W3093241002C170493617 @default.
• W3093241002 hasConceptScore W3093241002C198399640 @default.
• W3093241002 hasConceptScore W3093241002C2776752467 @default.
• W3093241002 hasConceptScore W3093241002C2778790584 @default.
• W3093241002 hasConceptScore W3093241002C2779134260 @default.
• W3093241002 hasConceptScore W3093241002C2780596555 @default.
• W3093241002 hasConceptScore W3093241002C2780775167 @default.
• W3093241002 hasConceptScore W3093241002C2911091166 @default.
• W3093241002 hasConceptScore W3093241002C529278444 @default.
• W3093241002 hasConceptScore W3093241002C71924100 @default.
• W3093241002 hasConceptScore W3093241002C86803240 @default.
• W3093241002 hasFunder F4320325437 @default.
• W3093241002 hasIssue "3" @default.
• W3093241002 hasLocation W30932410021 @default.
• W3093241002 hasLocation W30932410022 @default.
• W3093241002 hasOpenAccess W3093241002 @default.
• W3093241002 hasPrimaryLocation W30932410021 @default.
• W3093241002 hasRelatedWork W1972449685 @default.
• W3093241002 hasRelatedWork W1994737836 @default.
• W3093241002 hasRelatedWork W2057622844 @default.

• next